Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development

1994 • 284 citations

The surrogate light chain in B-cell development

1993 • 282 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

1994 • 238 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

1987 • 179 citations

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

1993 • 170 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.

1993 • 141 citations

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins.

1991 • 109 citations

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.

1991 • 79 citations

Frequent lambda light chain gene rearrangement and expression in a Ly-1 B lymphoma with a productive kappa chain allele.

1986 • 78 citations

The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

1991 • 77 citations

Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.

1990 • 76 citations

The Omega and Iota Surrogate Immunoglobulin Light Chains

1988 • 56 citations

Cell surface expression of the short immunoglobulin μ chain (Dμ protein) in murine pre-B cells is differently regulated from that of the intact μ chain

1991 • 52 citations

IL-2 receptor α chain expression during early B lymphocyte differentiation

1994 • 50 citations

Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells.

1994 • 46 citations

Discrete early pro‐B and pre‐B stages in normal human bone marrow as defined by surface pseudo‐light chain expression

1994 • 39 citations

Monoclonal anti-λ5 antibody FS1 identifies a 130 kDa protein associated with λ5 and V_pre-B on the surface of early pre-B cell lines

1994 • 35 citations