Expression of the V(D)J recombinase gene RAG-1 is tightly regulated and involves both transcriptional and post-transcriptional controls

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia

1965 • 1,213 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES

1990 • 1,121 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Translocations Among Antibody Genes in Human Cancer

1983 • 736 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.

1991 • 360 citations

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.

1990 • 350 citations

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

1990 • 347 citations

THE MECHANISM OF CONSERVATIVE SITE-SPECIFIC RECOMBINATION

1988 • 313 citations

Proto-oncogene fos: Complex but versatile regulation

1987 • 296 citations

REGULATED mRNA STABILITY

1990 • 279 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Phenotypic characterisation of a unique non-T, non-B acute lymphoblastic leukaemia cell line

1977 • 255 citations

Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.

1989 • 227 citations

TRANSPOSITIONAL RECOMBINATION IN PROKARYOTES

1985 • 223 citations

Posttranscriptional regulation of c-fos mRNA expression

1987 • 215 citations

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.

1985 • 207 citations

A Common Mechanism of Chromosomal Translocation in T- and B-Cell Neoplasia

1986 • 205 citations

Site-specific recombinases: changing partners and doing the twist

1986 • 202 citations

The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements

1988 • 186 citations

Analysis of the differentiation-promoting potential of inducible c-fos genes introduced into embryonal carcinoma cells.

1985 • 173 citations

ONCOGENE ACTIVATION BY CHROMOSOME TRANSLOCATION IN HUMAN MALIGNANCY

1987 • 169 citations

Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours.

1989 • 160 citations

A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

1989 • 157 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

c-myc RNA degradation in growing and differentiating cells: possible alternate pathways.

1989 • 98 citations

Regulation of Transposition in Bacteria

1990 • 98 citations

SOS induction and autoregulation of the himA gene for site-specific recombination in Escherichia coli.

1981 • 97 citations

Transcriptional and posttranscriptional control of c-myc gene expression in WEHI 231 cells.

1986 • 84 citations

Contributions of transcriptional and post-transcriptional mechanisms to the regulation of c-myc expression in mouse erythroleukemia cells.

1987 • 74 citations

V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.

1990 • 64 citations

Developmental rearrangement of cyanobacterial nitrogen-fixation genes

1986 • 54 citations

Chromosomal abnormalities in lymphoid tumours: mechanism and role in tumour pathogenesis

1988 • 51 citations

c-fos mRNA Expression in Macrophages Is Downregulated by Interferon-γ at the Posttranscriptional Level

1991 • 34 citations

c-fos mRNA expression in macrophages is downregulated by interferon-gamma at the posttranscriptional level.

1991 • 20 citations

Protein kinase C regulation of terminal deoxynucleotidyl transferase.

1989 • 13 citations

Growth and differentiation of a human T-cell leukemia cell line, CCRF-CEM, grafted in mice.

1989 • 7 citations

Phorbol ester regulation of terminal deoxynucleotidyl transferase, proliferation, and TcR α in a pre‐T cell line

1990 • 3 citations