Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases

AP-1 function and regulation

1997 • 2,833 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Calcium signaling

1995 • 1,905 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Antigen Receptors on B Lymphocytes

1992 • 509 citations

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

1997 • 505 citations

BLNK

1998 • 501 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Potassium and Calcium Channels in Lymphocytes

1995 • 488 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

1995 • 463 citations

Characterization of the B Lymphocyte Populations in Lyn-Deficient Mice and the Role of Lyn in Signal Initiation and Down-Regulation

1997 • 451 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

INITIATION AND PROCESSING OF SIGNALS FROM THE B CELL ANTIGEN RECEPTOR

1997 • 440 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

CD22 is a negative regulator of B-cell receptor signalling

1997 • 427 citations

Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection

1998 • 427 citations

Signal Transduction by the B Cell Antigen Receptor and its Coreceptors

1994 • 419 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Molecular components of the B-cell antigen receptor complex of the IgM class

1990 • 401 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

CD22 regulates thymus-independent responses and the lifespan of B cells

1996 • 395 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

1996 • 382 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

The complexity of signaling pathways activated by the BCR

1997 • 333 citations

A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells

1997 • 325 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

The B Cell Antigen Receptor Complex: Association of Ig-α and Ig-β with Distinct Cytoplasmic Effectors

1992 • 307 citations

Isolation of a src homology 2-containing tyrosine phosphatase.

1992 • 304 citations

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.

1994 • 299 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING^*

1997 • 296 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1997 • 274 citations

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

1998 • 271 citations

Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

1995 • 270 citations

Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45

1991 • 269 citations

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1998 • 268 citations

Inhibition of the B Cell by CD22: A Requirement for Lyn

1998 • 265 citations

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.

1995 • 264 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

1994 • 250 citations

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

1996 • 244 citations

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

1993 • 243 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor.

1996 • 237 citations

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.

1993 • 237 citations

Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.

1991 • 235 citations

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

1997 • 226 citations

Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases.

1995 • 222 citations

The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1

1998 • 208 citations

Intramolecular Regulation of Protein Tyrosine Phosphatase SH-PTP1: A New Function for Src Homology 2 Domains

1994 • 207 citations

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals

1998 • 206 citations

Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors

1993 • 206 citations

Requirement of SH2-containing Protein Tyrosine Phosphatases SHP-1 and SHP-2 for Paired Immunoglobulin-like Receptor B (PIR-B)–mediated Inhibitory Signal

1998 • 205 citations

Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

1991 • 205 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase

1991 • 204 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Tuning Antigen Receptor Signaling by CD22: Integrating Cues from Antigens and the Microenvironment

1997 • 195 citations

Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells

1992 • 195 citations

Molecular mechanisms in B cell antigen receptor signaling

1997 • 194 citations

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

1997 • 192 citations

Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor.

1994 • 190 citations

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.

1994 • 187 citations

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

1992 • 181 citations

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

1998 • 175 citations

Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

1996 • 174 citations

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

1994 • 172 citations

Cytosolic and stored calcium antagonistically control tyrosine phosphorylation of specific platelet proteins.

1991 • 170 citations

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

1994 • 169 citations

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.

1994 • 163 citations

Adaptor proteins in lymphocyte antigen-receptor signaling

1998 • 155 citations

Mutations of immunoglobulin transmembrane and cytoplasmic domains: Effects on intracellular signaling and antigen presentation

1990 • 154 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

Molecular and Cellular Aspects of X-Linked Agammaglobulinemia

1995 • 148 citations

Syk, Activated by Cross-linking the B-cell Antigen Receptor, Localizes to the Cytosol Where It Interacts with and Phosphorylates α-Tubulin on Tyrosine

1996 • 143 citations

Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.

1996 • 142 citations

Catalytic Specificity of Phosphotyrosine Kinases Blk, Lyn, c-Src and Syk as Assessed by Phage Display

1996 • 139 citations

Inhibitory signaling by B cell FcγRIIb

1998 • 138 citations

The Roles of γ1 Heavy Chain Membrane Expression and Cytoplasmic Tail in IgG1 Responses

1997 • 137 citations

Differential signaling through the Ig‐α and Ig‐β components of the B cell antigen receptor

1993 • 137 citations

SLP-76 Is a Direct Substrate of SHP-1 Recruited to Killer Cell Inhibitory Receptors

1998 • 136 citations

Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression.

1996 • 135 citations

Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.

1994 • 135 citations

Effect of Transmembrane and Cytoplasmic Domains of IgE on the IgE Response

1997 • 133 citations

Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.

1992 • 131 citations

Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.

1994 • 127 citations

Of ITAMs and ITIMs: turning on and off the B cell antigen receptor.

1995 • 124 citations

The Tyrosine Phosphatase PTP1C Associates with Vav, Grb2, and mSos1 in Hematopoietic Cells

1996 • 124 citations

X-Linked Immune Deficiency (xid) of CBA/N Mice

1986 • 123 citations

Phosphotyrosine‐dependent association between CD22 and protein tyrosine phosphatase 1C

1995 • 120 citations

Biochemistry of B Lymphocyte Activation

1993 • 120 citations

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

1997 • 120 citations

B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn

1993 • 112 citations

CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling

1997 • 111 citations

CD45 Modulates Phosphorylation of Both Autophosphorylation and Negative Regulatory Tyrosines of Lyn in B Cells

1996 • 110 citations

Tyrosine phosphorylation of phospholipase C-gamma 2 upon cross-linking of membrane Ig on murine B lymphocytes.

1992 • 109 citations

Counterregulation by the Coreceptors CD19 and CD22 of MAP Kinase Activation by Membrane Immunoglobulin

1997 • 106 citations

Regulation of Btk by Src Family Tyrosine Kinases

1996 • 106 citations

Btk dosage determines sensitivity to B cell antigen receptor cross-linking

1997 • 103 citations

The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases.

1992 • 103 citations

Inhibitory receptors abound?

1997 • 103 citations

Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs independently of its cytoplasmic tyrosines

1993 • 101 citations

The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface.

1990 • 101 citations

Amplification of human B cell activation by a monoclonal antibody to the B cell-specific antigen CD22, Bp 130/140.

1987 • 98 citations

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.

1995 • 94 citations

Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling

1995 • 93 citations

Asymmetrical Phosphorylation and Function of Immunoreceptor Tyrosine-Based Activation Motif Tyrosines in B Cell Antigen Receptor Signal Transduction

1998 • 91 citations

Anti-CD45 inhibition of human B cell proliferation depends on the nature of activation signals and the state of B cell activation. A study with anti-IgM and anti-CDw40 antibodies.

1989 • 91 citations

Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.

1996 • 91 citations

B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins.

1994 • 89 citations

The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment.

1994 • 84 citations

The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line.

1992 • 82 citations

Role of Btk in B cell development and signaling

1997 • 81 citations

B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1.

1993 • 81 citations

Syk Activation and Dissociation from the B-cell Antigen Receptor Is Mediated by Phosphorylation of Tyrosine 130

1997 • 80 citations

Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma.

1993 • 76 citations

Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein.

1995 • 75 citations

Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway.

1993 • 73 citations

Analysis of signaling via surface immunoglobulin receptors on b cells from cba/n mice

1989 • 70 citations

Hematopoietic Cell Phosphatase Is Recruited to CD22 following B Cell Antigen Receptor Ligation

1995 • 69 citations

The Role of CD45 in Signal Transduction

1997 • 69 citations

Signalling Function of the B‐Cell Antigen Receptors

1993 • 69 citations

Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells.

1997 • 67 citations

Analysis of Tyrosine Phosphorylation-dependent Interactions between Stimulatory Effector Proteins and the B Cell Co-receptor CD22

1999 • 66 citations

The Immunoglobulin (Ig)α and Igβ Cytoplasmic Domains Are Independently Sufficient to Signal B Cell Maturation and Activation in Transgenic Mice

1997 • 66 citations

Interactions of Lyn with the antigen receptor during B cell activation.

1994 • 66 citations

Involvement of p59fynT in interleukin-5 receptor signaling.

1995 • 65 citations

Transfected plasmacytoma cells do not transport the membrane form of IgM to the cell surface.

1988 • 61 citations

Receptor editing and commitment in B lymphocytes

1998 • 59 citations

Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.

1994 • 58 citations

Molecular Basis of the Motheaten Phenotype

1994 • 58 citations

B-cell receptor regulation of peripheral B cells

1998 • 58 citations

Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.

1994 • 57 citations

Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation

1992 • 56 citations

Association of p72 with the src Homology-2 (SH2) Domains of PLCγ1 in B Lymphocytes

1995 • 55 citations

Autophosphorylation Induces Autoactivation and a Decrease in the Src Homology 2 Domain Accessibility of the Lyn Protein Kinase

1995 • 55 citations

Nerve Growth Factor Stimulates Tyrosine Phosphorylation and Activation of Src Homology-containing Protein-tyrosine Phosphatase 1 in PC12 Cells

1995 • 54 citations

Functional reconstitution of an immunoglobulin antigen receptor in T cells.

1992 • 53 citations

Igα and Igβ Are Functionally Homologous to the Signaling Proteins of the T-Cell Receptor

1994 • 52 citations

Distinct p53/56^ and p59^ domains associate with nonphosphorylated and phosphorylated lgα.

1994 • 50 citations

Signal transduction: Clamping down on Src activity

1997 • 49 citations

Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction.

1993 • 48 citations

Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells.

1996 • 47 citations

B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.

1997 • 47 citations

Cooperativity and Segregation of Function within the Ig-α/β Heterodimer of the B Cell Antigen Receptor Complex

1996 • 47 citations

Lymphocyte homing: The scent of a follicle

1997 • 43 citations

Molecular targets of CD45 in B cell antigen receptor signal transduction.

1997 • 43 citations

Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor

1996 • 42 citations

Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta.

1994 • 39 citations

Cross-linking of surface immunoglobulin activates src-related tyrosine kinases in WEHI 231 cells

1992 • 38 citations

Regulation of ITAM Signaling by Specific Sequences in Ig-β B Cell Antigen Receptor Subunit

1996 • 38 citations

Superclustering of B cell receptor and Fc gamma RIIB1 activates Src homology 2-containing protein tyrosine phosphatase-1.

1998 • 36 citations

Vav: Function and Regulation in Hematopoietic Cell Signaling

1996 • 36 citations

B-Cell Antigen Receptor–Induced Apoptosis Requires Both Igα and Igβ

1997 • 36 citations

Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor.

1994 • 36 citations

Ig alpha and Ig beta are functionally homologous to the signaling proteins of the T-cell receptor.

1994 • 36 citations

B-cell lymphopoiesis in mouse and man

1998 • 35 citations

Differential structure-function requirements of the transmembranal domain of the B cell antigen receptor.

1992 • 35 citations

Regulation of basal tyrosine phosphorylation of the B cell antigen receptor complex by the protein tyrosine phosphatase, CD45.

1992 • 35 citations

CD45 Regulates Tyrosine Phosphorylation of CD22 and Its Association with the Protein Tyrosine Phosphatase SHP-1

1999 • 34 citations

Surface IgM-stimulated proliferation, inositol phospholipid hydrolysis, Ca2+ flux, and tyrosine phosphorylation are not altered in B cells from p59fyn-/- mice

1994 • 33 citations

Point mutations define a mIgM transmembrane region motif that determines intersubunit signal transduction in the antigen receptor.

1994 • 33 citations

Superclustering of B Cell Receptor and FcγRIIB1 Activates Src Homology 2-Containing Protein Tyrosine Phosphatase-1

1998 • 32 citations

Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.

1994 • 30 citations

Major Histocompatibility Class II-mediated Signal Transduction Is Regulated by the Protein-tyrosine Phosphatase CD45

1998 • 27 citations

Murine "viable motheaten" mutation reveals a gene critical to the development of both B and T lymphocytes.

1989 • 22 citations

B-Cell Antigen Receptor–Induced Apoptosis Requires Both Igα and Igβ

1997 • 21 citations

SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity.

1998 • 20 citations

COOH terminus of membrane IgM is essential for an antigen-specific induction of some but not all early activation events in mature B cells.

1991 • 19 citations

Role of the transmembrane and cytoplasmic domains of surface IgM in endocytosis and signal transduction

1992 • 19 citations

Mutations within the NH2-terminal transmembrane domain of membrane immunoglobulin (Ig) M alters Ig alpha and Ig beta association and signal transduction.

1994 • 15 citations

Administration of anti-CD45 mAb specific for a B cell-restricted epitope abrogates the B cell response to a T-dependent antigen in vivo.

1993 • 14 citations

Immune responses: Tails to teach a B cell

1997 • 8 citations

Kinase-independent potentiation of B cell antigen receptor-mediated signal transduction by the protein tyrosine kinase Src.

1997 • 7 citations