Molecular Basis of the Motheaten Phenotype

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

The cystatins: Protein inhibitors of cysteine proteinases

1991 • 813 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

1985 • 599 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Human Lymphocytes Making Rheumatoid Factor and Antibody to ssDNA Belong to Leu-1⁺B-Cell Subset

1987 • 490 citations

Mendelian inheritance in man

1993 • 430 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

Isolation of a src homology 2-containing tyrosine phosphatase.

1992 • 304 citations

The cystatins: a new class of peptidase inhibitors

1987 • 293 citations

Production of Immunoglobulin Isotypes by Ly-1 ⁺ B Cells in Viable Motheaten and Normal Mice

1986 • 290 citations

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1992 • 281 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids

1991 • 262 citations

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

1993 • 243 citations

Treatment of murine CD5⁻ B cells with anti-lg, but not LPS, induces surface CD5: two B-cell activation pathways

1991 • 224 citations

In Situ Hybridization Studies of Stromelysin and Collagenase Messenger RNA Expression in Rheumatoid Synovium

1991 • 206 citations

"Viable motheaten," a new allele at the motheaten locus. I. Pathology.

1984 • 205 citations

Motheaten, an Immunodeficient Mutant of the Mouse: I. Genetics and pathology

1975 • 198 citations

Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins.

1976 • 177 citations

An embryonic source of Ly1 but not conventional B cells

1991 • 145 citations

Cysteine Proteinases and their Inhibitors

1986 • 142 citations

Mechanisms of Matrix Degradation in Rheumatoid Arthritis^a

1990 • 132 citations

Phenotypic and Functional Characterization of Human LEUI (CD5) B Cells

1986 • 130 citations

Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia

1986 • 127 citations

Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).

1989 • 105 citations

Abnormalities of chromosome 12p 13 and malignant proliferation of eosinophils: a nonrandom association

1987 • 104 citations

Mutations in mice that influence natural killer (NK) cell activity

1981 • 95 citations

Motheaten, an Immunodeficient Mutant of the Mouse

1976 • 94 citations

Anti-DNA antibody production by CD5+ and CD5- B cells of patients with systemic lupus erythematosus.

1990 • 87 citations

Amino acid sequence of rat liver thiol proteinase inhibitor

1983 • 71 citations

Amino acid sequence of rat epidermal thiol proteinase inhibitor

1984 • 67 citations

Phenotypic and Functional Effects of the Motheaten Gene on Murine B and T Lymphocytes

1979 • 63 citations

Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis

1988 • 57 citations

Phorbol ester stimulates the activity of a protein tyrosine phosphatase containing SH2 domains (PTP1C) in HL-60 leukemia cells by increasing gene expression

1993 • 55 citations

B lymphocyte-associated antigens on terminal deoxynucleotidyl transferase-positive cells and pre-B cells in bone marrow of the rat.

1986 • 55 citations

Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6)

1992 • 52 citations

tdic(9;12): a nonrandom chromosome abnormality in childhood B-cell precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study

1987 • 50 citations

The mouse mutant "motheaten". I. Development of lymphocyte populations.

1978 • 49 citations

Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells.

1986 • 47 citations

Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice.

1988 • 41 citations

Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.

1987 • 35 citations

The Mouse Mutant “Motheaten”

1978 • 35 citations

Molecular Characterization and Mapping of Murine Genes Encoding Three Members of the Stefin Family of Cysteine Proteinase Inhibitors

1993 • 32 citations

Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice.

1991 • 31 citations

Generation of Ly‐1 B Cells from Developmentally Distinct Precursors

1992 • 26 citations

Mapping of the gene for human cysteine proteinase inhibitor stefin A, STF1, to chromosome 3cen-q21

1991 • 23 citations

Accelerated rate of mononuclear phagocyte production in vitro by splenocytes from autoimmune motheaten mice.

1983 • 21 citations

Spontaneous production of colony-stimulating activity by splenic mac-1 antigen-positive cells from autoimmune motheaten mice

1984 • 19 citations

Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.

1987 • 18 citations

Deficiency in cells expressing terminal transferase in autoimmune (motheaten) mice

1981 • 16 citations

Mode of activation of the precursor to cathepsin L: implication for matrix degradation in arthritis.

1990 • 12 citations

Spontaneous production of colony-stimulating activity by splenic Mac-1 antigen-positive cells from autoimmune motheaten mice.

1984 • 12 citations

Adoptive transfer of viable motheaten (mev) humoral autoimmunity: IgM to IgG switch of the hyperglobulinaemia in nude, beige recipient mice.

1990 • 10 citations

Side products in the synthesis of secretin.

1990 • 5 citations