Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

There is more than one interleukin 1

1986 • 1,226 citations

The Endocrinology and Developmental Biology of the Prostate*

1987 • 1,047 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells

1994 • 644 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds

1994 • 597 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

Hormone-Induced Morphogenesis and Growth: Role of Mesenchymal–Epithelial Interactions

1983 • 441 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop

1991 • 427 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

1991 • 415 citations

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

1993 • 408 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

1992 • 404 citations

Mutual induction of growth factor gene expression by epidermal-dermal cell interaction

1993 • 401 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

1993 • 390 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo.

1994 • 353 citations

The biology of epithelial cell populations

1984 • 339 citations

Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1

1995 • 329 citations

Keratinocyte growth factor

1995 • 321 citations

Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

1993 • 313 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors.

1992 • 279 citations

Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

1994 • 276 citations

FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions

1994 • 275 citations

Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

1993 • 263 citations

K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

1990 • 260 citations

Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: Differentiation response distinguishes KGF from EGF family

1990 • 228 citations

Regulation of keratinocyte growth factor gene expression by interleukin 1.

1994 • 217 citations

Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts.

1994 • 203 citations

Human keratinocyte growth factor effects in a porcine model of epidermal wound healing.

1993 • 200 citations

Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.

1988 • 193 citations

Normal and Abnormal Development of the Male Urogenital Tract

1992 • 191 citations

Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.

1990 • 187 citations

Keratinocyte growth factor functions in epithelial induction during seminal vesicle development.

1994 • 187 citations

Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea.

1993 • 186 citations

Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor.

1994 • 185 citations

Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin.

1994 • 182 citations

A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.

1992 • 165 citations

Keratinocyte Growth Factor (FGF-7) Stimulates Migration and Plasminogen Activator Activity of Normal Human Keratinocytes

1993 • 159 citations

Keratinocyte Growth Factor: A Fibroblast Growth Factor Family Member with Unusual Target Cell Specificity

1991 • 153 citations

Induction of growth factor RNA expression in human malignant melanoma: markers of transformation.

1991 • 151 citations

Related fibroblast growth factor receptor genes exist in the human genome.

1990 • 131 citations

Isolation of a rearranged human transforming gene following transfection of Kaposi sarcoma DNA.

1987 • 125 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to- epithelial-cell andromedin

1992 • 121 citations

Mesenchymal-epithelial interactions in the ovarian follicle involve keratinocyte and hepatocyte growth factor production by thecal cells and their action on granulosa cells.

1994 • 119 citations

A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity.

1992 • 112 citations

Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.

1994 • 111 citations

Different Members of the Fibroblast Growth Factor Receptor Family Are Specific to Distinct Cell Types in the Developing Chicken Embryo

1993 • 104 citations

Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor.

1991 • 101 citations

Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.

1988 • 98 citations

Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor.

1993 • 98 citations

Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants.

1993 • 96 citations

Keratinocyte growth factor induces pancreatic ductal epithelial proliferation.

1994 • 88 citations

Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription-polymerase chain reaction

1993 • 77 citations

Multiple structural elements determine ligand binding of fibroblast growth factor receptors. Evidence that both Ig domain 2 and 3 define receptor specificity.

1993 • 75 citations

Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor.

1994 • 75 citations

The Fibroblast Growth Factor Family An Overview

1991 • 72 citations

High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains.

1994 • 72 citations

K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase.

1992 • 66 citations

Differential expression of keratinocyte growth factor and its receptor in the human uterus

1993 • 64 citations

A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site

1993 • 61 citations

Postnatal Growth of Mouse Seminal Vesicle Is Dependent on 5α-Dihydrotestosterone*

1990 • 60 citations

Role of stroma in oestrogen-induced epithelial proliferation.

1992 • 50 citations

Interactions of growth factors and retroviral oncogenes with mitogenic signal transduction pathways of Balb/MK keratinocytes.

1988 • 49 citations

Keratinocyte Growth Factor and Fibroblast Growth Factor Action on DNA Synthesis in Rat and Human Hepatocytes: Modulation by Heparin

1994 • 48 citations

Hypothesis: Persistent Expression of Fetal Phenotypic Characteristics by Fibroblasts Is Associated with an Increased Susceptibility to Neoplastic Disease

1987 • 47 citations

Expression of Fibroblast Growth Factor Gene Family and Its Receptor Gene Family in the Human Upper Gastrointestinal Tract

1994 • 42 citations

Fibroblast Growth Factors in Normal and Malignant Melanocytes^a

1991 • 41 citations

Expression of Fibroblast Growth Factor Receptor-2 Splice Variants is Developmentally and Tissue-Specifically Regulated in the Amphibian Embryo

1994 • 37 citations

Preferential expression of the third immunoglobulin-like domain of K-sam product provides keratinocyte growth factor-dependent growth in carcinoma cell lines.

1994 • 28 citations

Keratinocyte Growth Factor as a Mitogen for Primary Culture of Rat Hepatocytes

1993 • 26 citations

Mesenchymal-epithelial interactions in the ovarian follicle involve keratinocyte and hepatocyte growth factor production by thecal cells and their action on granulosa cells

1994 • 20 citations

Tissue-specific expression of two isoforms of chicken fibroblast growth factor receptor, bek and Cek3.

1992 • 12 citations

The role of growth factors in the development and growth of the prostate and seminal vesicle

1994 • 11 citations

Spleen‐derived growth factor, SDGF‐3, is identified as keratinocyte growth factor (KGF)

1993 • 11 citations