Celecoxib: A Specific COX-2 Inhibitor with Anticancer Properties

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis

2000 • 3,176 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Hepatogastroenterology

2012 • 2,302 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

The role of cyclooxygenases in inflammation, cancer, and development

1999 • 1,399 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

1998 • 933 citations

Aspirin use and risk of fatal cancer.

1993 • 884 citations

COX-2 is expressed in human pulmonary, colonic, and mammary tumors

2000 • 872 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study

1994 • 746 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.

1999 • 722 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

COX-1 and COX-2 tissue expression: implications and predictions.

1997 • 670 citations

The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2

2000 • 670 citations

Cyclooxygenase-2 expression in human esophageal carcinoma.

1999 • 670 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Incidence of Cancer Among Patients With Rheumatoid Arthritis

1993 • 596 citations

A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer

1991 • 519 citations

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.

2000 • 494 citations

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

2000 • 481 citations

Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.

2000 • 462 citations

Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo.

2002 • 444 citations

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

1996 • 421 citations

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.

1996 • 418 citations

Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.

1998 • 413 citations

Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.

1999 • 405 citations

INHIBITION OF CYCLOOXYGENASE-2 SUPPRESSES ANGIOGENESIS AND THE GROWTH OF PROSTATE CANCER IN VIVO

2000 • 361 citations

Nonsteroidal Antiinflammatory Drugs and Breast Cancer

1996 • 352 citations

Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells

1995 • 348 citations

Hypoxic induction of interleukin-8 gene expression in human endothelial cells.

1994 • 346 citations

Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition

1999 • 334 citations

Cyclooxygenase-2 is overexpressed in human cervical cancer.

2001 • 330 citations

Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.

2001 • 324 citations

Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models.

2000 • 320 citations

Expression of cyclooxygenase-2 in prostate carcinoma

2000 • 319 citations

Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas.

1999 • 315 citations

Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.

2000 • 305 citations

Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells.

2000 • 305 citations

Aspirin and reduced risk of esophageal carcinoma

1995 • 290 citations

Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder.

1999 • 289 citations

Aspirin use, cancer, and polyps of the large bowel

1993 • 285 citations

A guideline for the treatment and prevention of NSAID-induced ulcers

1998 • 284 citations

Cyclooxygenase-2 Overexpression Enhances Lymphatic Invasion and Metastasis in Human Gastric Carcinoma

1999 • 281 citations

Cyclooxygenase-2 gene expression in human breast cancer

1997 • 274 citations

Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats.

2000 • 263 citations

NSAID induced gastrointestinal complications: the ARAMIS perspective--1997. Arthritis, Rheumatism, and Aging Medical Information System.

1998 • 250 citations

A guideline for the treatment and prevention of nsaid-induced ulcers

1998 • 246 citations

Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens

1999 • 241 citations

Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice

1998 • 236 citations

Enhancement of Tumor Response to -Radiation by an Inhibitor of Cyclooxygenase-2 Enzyme

1999 • 229 citations

Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer

2000 • 229 citations

Regulation of Cyclooxygenase-2 pathway by HER2 receptor

1999 • 226 citations

Aspirin and Nonsteroidal Anti-inflammatory Drug Use and the Risk of Subsequent Colorectal Cancer

1994 • 210 citations

Role of Cyclooxygenases in Angiogenesis

2000 • 200 citations

Nonsteroidal antiinflammatory drugs and colorectal cancer

1994 • 195 citations

Overexpression of cyclooxygenase-2 in carcinoma of the pancreas.

1999 • 188 citations

Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase‐2 (COX‐2) expression and inhibited by a COX‐2–selective inhibitor, etodolac

2001 • 188 citations

Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells.

1999 • 186 citations

Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer.

1999 • 177 citations

Cyclooxygenase-2 expression in hepatocellular carcinoma.

1999 • 175 citations

Carcinogen substrate specificity of human COX-1 and COX-2

2001 • 165 citations

Chemotherapeutic evaluation of Celecoxib, a cyclooxygenase-2 inhibitor, in a rat mammary tumor model.

2000 • 165 citations

Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac

2001 • 164 citations

Non-small cell lung cancer-derived soluble mediators and prostaglandin E2 enhance peripheral blood lymphocyte IL-10 transcription and protein production.

1996 • 160 citations

Rheumatoid arthritis: the role of the kinder and gentler therapies.

1990 • 154 citations

Nonsteroidal antiinflammatory drugs and colorectal cancer

1994 • 154 citations

Differential Regulation of Cyclooxygenases 1 and 2 by Interleukin-1β, Tumor Necrosis Factor-α, and Transforming Growth Factor-β1 in Human Lung Fibroblasts

1998 • 146 citations

Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents

1997 • 140 citations

Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.

2000 • 129 citations

Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor.

1987 • 129 citations

Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation

2000 • 129 citations

NSAID USE AND DECREASED RISK OF GASTROINTESTINAL CANCERS

1996 • 124 citations

Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy

1999 • 123 citations

Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor.

1988 • 117 citations

Modulation of rat mammary carcinogenesis by indomethacin.

1985 • 112 citations

Nonsteroidal anti-inflammatory drug use and protection against colorectal cancer in women.

1996 • 101 citations

Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder.

2001 • 90 citations

Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

1998 • 89 citations

Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer

1999 • 70 citations

Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation.

1993 • 68 citations

Rapid and transient induction of cyclo-oxygenase 2 by epidermal growth factor in human amnion-derived WISH cells

1997 • 62 citations

Inhibition of Tumor Necrosis Factor α-Stimulated Aromatase Activity by Microtubule-Stabilizing Agents, Paclitaxel and 2-Methoxyestradiol

1999 • 49 citations

Clinicopathologic Association of Cyclooxygenase 1 and Cyclooxygenase 2 Expression in Gastric Adenocarcinoma

2001 • 46 citations

EPIDEMIOLOGIC-STUDY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND BREAST-CANCER

1995 • 44 citations

Non-steroidal anti-inflammatory drugs and the chemoprevention of colorectal and oesophageal cancers.

1996 • 43 citations

Cox-2 expression in retinoblastoma

2000 • 36 citations

Comparative chemopreventive activity of ibuprofen and N-(4-hydroxyphenyl) retinamide against the development and growth of rat mammary adenocarcinomas.

2000 • 28 citations

Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2α (PGF2α) induced mitogenesis in Swiss 3T3 cells

1993 • 27 citations

Prostacyclin and thromboxane in benign and malignant breast tumours

1986 • 22 citations

COX-2 inhibitor enhances tumor radioresponse in vitro and in vivo

1999 • 2 citations