Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study

1994 • 746 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

1995 • 565 citations

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.

1996 • 418 citations

Nonsteroidal Antiinflammatory Drugs and Breast Cancer

1996 • 352 citations

Regulation of prostaglandin synthase-1 and prostaglandin synthase-2

1994 • 337 citations

Cyclooxygenase-2 gene expression in human breast cancer

1997 • 274 citations

Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer.

1999 • 177 citations

Cyclooxygenase 2 induction: Molecular mechanism and pathophysiologic roles

1996 • 111 citations

Breast Cancer and NSAID Use: Heterogeneity of Effect in a Case-Control Study

1995 • 73 citations

EPIDEMIOLOGIC-STUDY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND BREAST-CANCER

1995 • 44 citations

Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells

1993 • 26 citations

Effects of gamma-linolenic and dihomo-gamma-linolenic acids on 7,12-dimethylbenz(α)anthracene-induced mammary tumors in rats

1995 • 11 citations