Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

Regulation of the immune response by prostaglandins

1983 • 717 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Sunlight Exposure, Pigmentary Factors, and Risk of Nonmelanocytic Skin Cancer

1995 • 503 citations

Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects

1998 • 485 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Clinical Implications of Prostaglandin and Thromboxane A₂Formation

1988 • 450 citations

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

1996 • 421 citations

A methodology for analysis of tissue sulfhydryl components

1972 • 413 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 • 413 citations

Clinical Implications of Prostaglandin and Thromboxane A₂Formation

1988 • 365 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition

1999 • 334 citations

Immunological Unresponsiveness Induced by Ultraviolet Radiation

1984 • 314 citations

Sunlight and the onset of skin cancer

1997 • 302 citations

The clinical significance of inhibition of renal prostaglandin synthesis

1987 • 299 citations

Mechanisms of UV-Induced Inflammation.

1993 • 277 citations

Cyclooxygenase-2 gene expression in human breast cancer

1997 • 274 citations

Kinetic basis for selective inhibition of cyclo-oxygenases

1999 • 272 citations

Mechanisms of UV-Induced Inflammation

1993 • 269 citations

Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin.

1999 • 238 citations

The role of IL-4, IL-10, and TNF-α in the immune suppression induced by ultraviolet radiation

1994 • 228 citations

Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis.

1986 • 206 citations

Acute Effects of Ultraviolet Radiation on the Skin

2018 • 196 citations

The sunburn cell.

1987 • 170 citations

Pharmacologic Agents Released in Ultraviolet Inflammation Studied by Continuous Skin Perfusion

1970 • 167 citations

The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention

1995 • 166 citations

The role of childhood exposure to sunlight in the development of solar keratoses and non‐melanocytic skin cancer

1990 • 159 citations

Effects of indomethacin, 5,8,11,14-eicosatetraynoic acid, and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes

1980 • 153 citations

Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis

1995 • 149 citations

Increased prostaglandins E2 and F2alpha in human skin at 6 and 24 h after ultraviolet B irradiation (290− 320 nm).

1978 • 144 citations

Prostaglandins, their inhibitors and cancer

1996 • 143 citations

Myeloperoxidase as a biomarker of skin irritation and inflammation

1994 • 139 citations

Chemotactic factor‐induced generation of superoxide radicals by human neutrophils

1979 • 122 citations

Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)

1989 • 121 citations

Prostaglandins in squamous cell carcinoma of the head and neck: A preliminary study

1985 • 120 citations

Polyphenolic Antioxidant (−)-Epigallocatechin-3-Gallate from Green Tea Reduces UVB-Induced Inflammatory Responses and Infiltration of Leukocytes in Human Skin

1999 • 114 citations

Cyclooxygenase 2 induction: Molecular mechanism and pathophysiologic roles

1996 • 111 citations

Measurement of arachidonate and its metabolites extracted from human normal and malignant gastrointestinal tissues.

1987 • 109 citations

Analysis of the Mechanism of Ultraviolet (UV) B Radiation – Induced Prostaglandin E2 Synthesis by Human Epidermoid Carcinoma Cells

1993 • 107 citations

In vivo effects of indomethacin on the growth of murine mammary tumors.

1984 • 103 citations

Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats by non-steroid anti-inflammatory agent indomethacin

1983 • 94 citations

Induction of Cyclooxygenase-2 Expression by Peroxisome Proliferators and Non-tetradecanoylphorbol 12,13-Myristate-type Tumor Promoters in Immortalized Mouse Liver Cells

1997 • 90 citations

PROSTAGLANDINS, NSAIDs, AND CYTOPROTECTION

1992 • 90 citations

Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

1998 • 89 citations

The production of prostanoids in human cancers, and their implications for tumor progression

1986 • 89 citations

Increased synthesis of high-molecular-weight cPLA2 mediates early UV-induced PGE2 in human skin

1996 • 87 citations

Xenobiotic metabolism by prostaglandin H synthase

1992 • 83 citations

Kinetic basis for selective inhibition of cyclo-oxygenases

1999 • 82 citations

Cutaneous Effects of Topical Indomethacin, An Inhibitor of Prostaglandin Synthesis, on Uv-Damaged Skin

1975 • 81 citations

Prostaglandin in Human and Albino Rat Skin

1972 • 81 citations

Inhibition of mammary carcinogenesis by flurbiprofen, a non-steroidal antiinflammatory agent

1983 • 77 citations

Characterization of sunburn cells after exposure to ultraviolet light

1995 • 73 citations

Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs.

2000 • 66 citations

Immunological Effects of Ultraviolet Radiation

1991 • 55 citations

Possible Involvement of Enhanced Prostaglandin E2 Production in the Photosensitivity in Xeroderma Pigmentosum Group A Model Mice

2000 • 49 citations

Prostaglandins in Peptic Ulcer Disease

1986 • 46 citations

Hypochlorous Acid Activates the Tumor Suppressor Protein p53 in Cultured Human Skin Fibroblasts

1998 • 46 citations

The study of ultraviolet B-induced apoptosis in cultured mouse keratinocytes and in mouse skin

1996 • 46 citations

ULTRAVIOLET RADIATION‐INDUCED PHOSPHOLIPASE A₂ ACTIVATION OCCURS IN MAMMALIAN CELL MEMBRANE PREPARATIONS

1993 • 40 citations

Inhibition of Human Polymorphonuclear Leukocyte Cell Responses by Ibuprofen

1984 • 39 citations

Multifactor regulation of prostaglandin H synthase-2 in murine keratinocytes

1996 • 35 citations

ULTRAVIOLET RADIATION EFFECTS ON IMMUNE PROCESSES

1982 • 33 citations

Measurement of skin‐fold thickness in the guinea pig

1993 • 26 citations

Increased levels of 6‐oxo‐PGF1 alpha in human skin following ultraviolet B irradiation.

1982 • 26 citations

Analysis of two inbred strains of mice derived from the SENCAR stock with different susceptibility to skin tumor progression

1998 • 25 citations

Activation of Neutrophil Membrane-Associated Oxidative Metabolism by Ultraviolet Radiation

1993 • 22 citations

Ultraviolet B radiation-induced production of interleukin 1α and interleukin 6 in a human squamous carcinoma cell line is wavelength-dependent and can be inhibited by pharmacological agents

1998 • 21 citations

Genetic Variation in Low-Dose UV-Induced Suppression of Contact Hypersensitivity and in the Skin Photocarcinogenesis Response.

1997 • 20 citations

Photoprotective Effect of Topical Indomethacin – An Experimental Study

1985 • 19 citations

Inhibitory effects of pentoxifylline on ultraviolet B light-induced cutaneous inflammation.

1998 • 19 citations

Inhibitory effects of pentoxifylline on ultraviolet B light–induced cutaneous inflammation

1998 • 17 citations

Photocarcinogenesis in the Skin

1991 • 15 citations

Practical implications of cyclooxygenase-2--specific inhibitors in orthopedics.

1999 • 13 citations

Effects of benoxaprofen on human neutrophil function.

1984 • 3 citations