A guideline for the treatment and prevention of NSAID-induced ulcers

Final Report on the Aspirin Component of the Ongoing Physicians' Health Study

1989 • 2,180 citations

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

1991 • 1,260 citations

Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

1995 • 1,071 citations

Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans

1993 • 1,003 citations

Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

1994 • 981 citations

Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs

1992 • 956 citations

Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs

1994 • 881 citations

Omeprazole Compared with Misoprostol for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs

1998 • 874 citations

Nonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons

1991 • 783 citations

A Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs

1998 • 777 citations

Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration.

1987 • 643 citations

PREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

1988 • 615 citations

Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs

1991 • 606 citations

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND BLEEDING PEPTIC ULCER

1986 • 550 citations

Famotidine for the Prevention of Gastric and Duodenal Ulcers Caused by Nonsteroidal Antiinflammatory Drugs

1996 • 444 citations

Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product

1996 • 432 citations

Nonsteroidal Anti-Inflammatory Drug Use and Death from Peptic Ulcer in Elderly Persons

1988 • 430 citations

Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers

1997 • 410 citations

Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease

1991 • 402 citations

Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine.

1988 • 388 citations

Effect of Omeprazole and Ranitidine on Ulcer Healing and Relapse Rates in Patients with Benign Gastric Ulcer

1989 • 382 citations

Nonsteroidal anti-inflammatory drug-associated gastropathy: Incidence and risk factor models

1991 • 364 citations

RISING FREQUENCY OF ULCER PERFORATION IN ELDERLY PEOPLE IN THE UNITED KINGDOM

1986 • 357 citations

Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans

1987 • 353 citations

Diaphragm disease: pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs.

1988 • 353 citations

Nonsteroidal Anti-Inflammatory Drugs Activate Quiescent Inflammatory Bowel Disease

1987 • 353 citations

Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage.

1985 • 346 citations

Risk of Hospitalization for Upper Gastrointestinal Tract Bleeding Associated With Ketorolac, Other Nonsteroidal Anti-inflammatory Drugs, Calcium Antagonists, and Other Antihypertensive Drugs

1998 • 343 citations

Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs

1991 • 327 citations

Incidence of Gastric Lesions in Patients with Rheumatic Disease on Chronic Aspirin Therapy

1979 • 322 citations

Nonsteroidal anti-inflammatory drug enteropathy in rats: Role of permeability, bacteria, and enterohepatic circulation

1997 • 321 citations

Concurrent Use of Nonsteroidal Anti-inflammatory Drugs and Oral Anticoagulants Places Elderly Persons at High Risk for Hemorrhagic Peptic Ulcer Disease

1993 • 321 citations

INTESTINAL PERMEABILITY AND INFLAMMATION IN RHEUMATOID ARTHRITIS: EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

1984 • 310 citations

Duodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs

1993 • 300 citations

Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs

1993 • 283 citations

Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.

1985 • 275 citations

Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine.

1986 • 270 citations

Endoscopic Evaluation of the Effects of Aspirin, Buffered Aspirin, and Enteric-Coated Aspirin on Gastric and Duodenal Mucosa

1980 • 266 citations

Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease.

1997 • 250 citations

Effect of ranitidine gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs

1989 • 244 citations

Prevention of Peptic Ulcer and Dyspeptic Symptoms with Omeprazole in Patients Receiving Continuous Non-Steroidal Anti-Inflammatory Drug Therapy: A Nordic Multicentre Study

1996 • 229 citations

Clinicopathological features of nonsteroidal antiinflammatory drug-induced small intestinal strictures

1988 • 212 citations

Evidence of aspirin use in both upper and lower gastrointestinal perforation

1997 • 206 citations

Misoprostol Dosage in the Prevention of Nonsteroidal Anti-inflammatory Drug-Induced Gastric and Duodenal Ulcers: A Comparison of Three Regimens

1995 • 189 citations

Histopathology of intestinal inflammation related to reactive arthritis.

1987 • 179 citations

Misoprostol Compared with Sucralfate in the Prevention of Nonsteroidal Anti-inflammatory Drug-induced Gastric Ulcer

1991 • 169 citations

Analgesic ingestion and other factors preceding relapse in ulcerative colitis.

1983 • 163 citations

Enteroscopic diagnosis of small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs

1991 • 160 citations

Ranitidine in the treatment of non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers.

1991 • 149 citations

Sucralfate

1991 • 145 citations

Colitis induced by nonsteroidal anti-inflammatory drugs. Report of four cases and review of the literature

1992 • 142 citations

Role of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in longterm NSAID users. Response to omeprazole dual therapy.

1996 • 141 citations

Peptic ulcer bleeding in the elderly: relative roles ofHelicobacter pylori and non-steroidal anti-inflammatory drugs

1997 • 139 citations

Excess costs from gastrointestinal disease associated with nonsteroidal anti-inflammatory drugs

1996 • 138 citations

Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin--analysis of gastrointestinal bleeding during the UK-TIA trial.

1995 • 134 citations

Famotidine for healing and maintenance in nonsteroidal anti- inflammatory drug-associated gastroduodenal ulceration

1997 • 128 citations

Clinical therapeutics

1994 • 128 citations

Non-steroidal anti-inflammatory drugs and complicated diverticular disease: A case—control study

1991 • 125 citations

The Effect of Chronic Aspirin Use on Duodenal and Gastric Ulcer Hospitalizations

1990 • 123 citations

A Review of Gastric Ulcer and Gastroduodenal Injury in Normal Volunteers Receiving Aspirin and Other Non-Steroidal Anti-Inflammatory Drugs

1989 • 123 citations

THE RISKS AND COSTS OF UPPER GASTROINTESTINAL DISEASE ATTRIBUTABLE TO NSAIDS

1996 • 113 citations

INCREASED INTESTINAL PERMEABILITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: A SIDE-EFFECT OF ORAL NONSTEROIDAL ANTI-INFLAMMATORY DRUG THERAPY?

1987 • 105 citations

A double-blind study of prophylactic effect of misoprostol on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects

1986 • 101 citations

Complications of diverticular disease and non-steroidal anti-inflammatory drugs: A prospective study

1990 • 100 citations

Major upper gastrointestinal tract bleeding. Relation to the use of aspirin and other nonnarcotic analgesics

1988 • 95 citations

Omeprazole ameliorates aspirin-induced gastroduodenal injury

1994 • 80 citations

Prevalence of Helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis.

1993 • 80 citations

Effects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage

1992 • 78 citations

Efficacy of 12 Months' Misoprostol as Prophylaxis against IMSAID-induced Gastric Ulcers:A placebo-controlled trial

1994 • 77 citations

Duodenal histology, ulceration, and Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs.

1993 • 70 citations

Meta‐analysis of randomized controlled trials as a method of estimating rare complications of non‐steroidal anti‐inflammatory drug therapy

1988 • 70 citations

RECTAL BLEEDING AND INDOMETHACIN SUPPOSITORIES

1975 • 70 citations

Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy.

1992 • 66 citations

Misoprostol Reduces Gastroduodenal Injury From One Week of Aspirin: An Endoscopic Study

1989 • 64 citations

A Long-Term Study to Evaluate the Safety and Efficacy of Meloxicam Therapy in Patients with Rheumatoid Arthritis

1996 • 61 citations

The prevalence of duodenal lesions in patients with rheumatic diseases on chronic aspirin therapy

1980 • 59 citations

THE PREVENTION AND HEALING OF ACUTE NON-STEROIDAL ANTI-INFLAMMATORY DRUG-ASSOCIATED GASTRODUODENAL MUCOSAL DAMAGE BY MISOPROSTOL

1993 • 55 citations

Protection by misoprostol against naproxen-induced gastric mucosal damage

1987 • 54 citations

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, ARTHRITIS, AND GASTRO INTESTINAL BLEEDING IN ELDERLY IN-PATIENTS

1984 • 50 citations

Nizatidine Prevents Peptic Ulceration in High-Risk Patients Taking Nonsteroidal Anti-inflammatory Drugs

1993 • 49 citations

High‐dose ranitidine for the prevention of recurrent peptic ulcer disease in rheumatoid arthritis patients taking NSAIDs.

1996 • 45 citations

Helicobacter pylori Infection Increases the Risk of Peptic Ulcers in Chronic Users of Non-steroidal Anti-inflammatory Drugs

1996 • 33 citations

Benign Ulcer of the Sigmoid Colon

1968 • 33 citations

The relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs

1987 • 31 citations

Endoscopic demonstration of non-steroidal anti-inflammatory drug-induced small intestinal strictures

1992 • 29 citations

Prevention of nonsteroidal anti-inflammatory drug-induced gastrointestinal mucosal injury. A meta-analysis of randomized controlled clinical trials

1996 • 28 citations

Rectal Bleeding and Indomethacin

1968 • 27 citations

Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin

1989 • 24 citations

An Overview of the Long Term Safety Experience of Nabumetone

1990 • 18 citations

RANITIDINE IN THE TREATMENT OF GASTRIC AND DUODENAL ULCERS ASSOCIATED WITH NON-STEROIDAL ANTI INFLAMMATORY DRUGS

1993 • 18 citations

Large-scale open trials with etodolac (Lodine®) in France: An assessment of safety

1990 • 18 citations

Risk and cost of gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs

1989 • 18 citations

A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa

1993 • 15 citations

Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly

1987 • 14 citations

A 12-Month Postmarketing Surveillance Study of Nabumetone

1990 • 14 citations

Nizatidine in Therapy and Prevention of Non-steroidal Antiinflammatory Drug-induced Gastroduodenal Ulcer in Rheumatic Patients

1994 • 14 citations

Sulglycotide in the Prevention of Nonsteroidal Anti-inflammatory Drug-Induced Gastroduodenal Mucosal Injury: A Controlled Double-Blind, Double-Dummy, Randomized Endoscopic Study versus Placebo in Rheumatic Patients

1993 • 11 citations

German Drug Monitoring Studies with Nabumetone

1990 • 9 citations