Pathology of Alzheimer's Disease

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1988 • 1,186 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study

1986 • 999 citations

The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education

1990 • 977 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

1986 • 704 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

1989 • 433 citations

Delirium, a syndrome of cerebral insufficiency

1959 • 421 citations

The neuropathology of aminergic nuclei in Alzheimer's disease

1988 • 419 citations

Heat shock proteins: the search for functions.

1986 • 395 citations

A4 amyloid protein deposition and the diagnosis of Alzheimer's disease

1988 • 367 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

Aberrant neurofilament phosphorylation in Alzheimer disease.

1985 • 339 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

The incidence of cerebral amyloid angiopathy in Alzheimer's disease

1975 • 276 citations

Alzheimer's disease: a correlative study.

1986 • 269 citations

MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE

1989 • 266 citations

Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease

1988 • 254 citations

Women, myocardial infarction, and dementia in the very old

1990 • 252 citations

Aminergic systems in Alzheimer's disease and Parkinson's disease

1987 • 241 citations

Alz-50, Ubiquitin and Tau Immunoreactivity of Neurofibrillary Tangles, Pick Bodies and Lewy Bodies

1988 • 238 citations

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

1989 • 238 citations

Quantitation of cerebral atrophy in preclinical and end-stage alzheimer's disease

1989 • 226 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

1989 • 219 citations

Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: Normal anatomy and alterations in alzheimer's disease

1988 • 219 citations

Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type

1985 • 209 citations

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

1988 • 201 citations

Alzheimer's disease: Neurofibrillary tangles in nuclei that project to the cerebral cortex

1987 • 199 citations

Familial aggregation in Alzheimer's disease

1988 • 195 citations

The nucleus basalis of Meynert in neurological disease: A quantitative morphological study

1985 • 191 citations

Alz‐50 Antibody recognizes alzheimer‐related neuronal changes

1988 • 177 citations

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

1990 • 174 citations

Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease

1989 • 168 citations

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

1985 • 164 citations

Microtubular reorganization and dendritic growth response in alzheimer's disease

1989 • 159 citations

Tissue-specific expression of three types of β-protein precursor mRNA: Enhancement of protease inhibitor-harboring types in Alzheimer's disease brain

1989 • 152 citations

THE ASSOCIATION OF CLINICAL AND NEUROLOGICAL FINDINGS AND ITS BEARING ON THE CLASSIFICATION AND AETIOLOGY OF ALZHEIMER'S DISEASE

1986 • 149 citations

Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor.

1990 • 145 citations

Cytoskeletal protein abnormalities in neurodegenerative diseases

1986 • 137 citations

Induction of Alzheimer Antigens by an Uncoupler of Oxidative Phosphorylation

1990 • 136 citations

Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors.

1986 • 135 citations

Case‐control study of late onset “probable Alzheimer's disease”

1987 • 130 citations

Metabolic Processes in Alzheimer's Disease: Adenine Nucleotide Content and Production of ¹⁴CO₂ from [U‐¹⁴C]Glucose In Vitro in Human Neocortex

1983 • 126 citations

Age at Onset and Rate of Progression of Alzheimer's Disease

1987 • 119 citations

Evidence for lysosomal processing of amyloid ?-protein precursor in cultured cells

1989 • 114 citations

Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats

1988 • 111 citations

ALTERATIONS IN ACETYLCHOLINE SYNTHESIS AND CYCLIC NUCLEOTIDES IN MILD CEREBRAL HYPOXIA

1978 • 107 citations

Alz 50, a monoclonal antibody to Alzheimer's disease antigen, cross-reacts with tau proteins from bovine and normal human brain.

1988 • 107 citations

Microheterogeneity of Micro tubule‐Associated τ Proteins Is Due to Differences in Phosphorylation

1986 • 106 citations

Amyloid β-protein precursor is associated with extracellular matrix

1990 • 106 citations

About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation

1989 • 105 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Alzheimer Disease: Clinical and Biological Heterogeneity

1988 • 99 citations

Hirano bodies contain tau protein

1987 • 95 citations

Age-related neuropsychological deficits in Down's syndrome.

1984 • 93 citations

Alz-50 recognizes a phosphorylated epitope of tau protein

1990 • 93 citations

Ubiquitin has intrinsic proteolytic activity: implications for cellular regulation.

1987 • 92 citations

Amyloidosis of the nervous system

1989 • 92 citations

Hypothesis: microtubules, a key to Alzheimer disease.

1989 • 91 citations

New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies

1989 • 90 citations

Aging and Cell Structure

1981 • 90 citations

THE ROLE OF THE NUCLEUS BASALIS OF MEYNERT IN DEMENTIA: REVIEW AND RECONSIDERATION

1987 • 88 citations

Age and Histopathologic Heterogeneity in Alzheimer's Disease

1987 • 88 citations

Ubiquitin is a component of the microtubule network.

1988 • 88 citations

Effects of oral physostigmine in Alzheimer's disease

1987 • 87 citations

Substance P‐like immunoreactivity is reduced in Alzheimer's disease cerebral cortex

1987 • 86 citations

Decreased adhesiveness of alzheimer's disease fibroblasts: Is amyloid β‐protein precursor involved?

1989 • 79 citations

The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition

1989 • 78 citations

Tau protein: An update on structure and function

1990 • 78 citations

Selective alteration of mouse brain neurotransmitter release with age

1987 • 76 citations

Altered expression of genes for amyloid and cytoskeletal proteins in alzheimer cortex

1989 • 70 citations

Deposition of amyloid (A4) protein within the brains of persons with dementing disorders other than Alzheimer's disease and Down's syndrome

1990 • 67 citations

Neuropathological Diagnosis of Alzheimer Disease

1989 • 64 citations

Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid β-protein

1989 • 64 citations

Reorganization of HeLa cell cytoskeleton induced by an uncoupler of oxidative phosphorylation

1982 • 54 citations

Sequestration of Tubulin in Neurons in Alzheimer's disease

1986 • 53 citations

Philothermal response of polymorphonuclear leukocytes in dementia of the Alzheimer type

1982 • 48 citations

Systemic manifestations of Alzheimer’s disease

1988 • 43 citations

Metabolic inhibitors and intermediate filament organization in human fibroblasts

1988 • 41 citations

The Early Story of Alzheimerʼs Disease

1988 • 37 citations

Expression of 'Alzheimer Antigens' in Cultured Skin Fibroblasts

1991 • 27 citations

Phosphatidylinositol Metabolism During In Vitro Hypoxia

1989 • 22 citations

IMMUNOELECTRON MICROSCOPY OF ALZHEIMER AND PICK BRAIN TISSUE LABELLED WITH THE MONOCLONAL ANTIBODY ALZ–50

1989 • 20 citations

Aberrant protein phosphorylation and cytoarchitecture in Alzheimer's disease.

1989 • 19 citations

Cultured Cells as a Screen for Novel Treatments of Alzheimer's Disease

1989 • 17 citations

Leukoaraiosis in asymptomatic adult offspring of individuals with Alzheimer's disease

1990 • 15 citations

Binswanger's Disease (Part II): Pathogenesis of Subcortical Arteriosclerotic Encephalopathy and Its Relation to Other Dementing Processes

1989 • 15 citations

Causes of cell damage in hypoxia/ischemia, aging and Alzheimer's disease

1989 • 11 citations

Study of Spindle Microtubule Reassembly in Cells from Alzheimer and Down Syndrome Patients Following Exposure to Colcemid

1990 • 9 citations

Paired helical filaments: Do they contain neurofilament epitopes?

1986 • 9 citations