A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process

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Matrix Metalloproteinases

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The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases

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The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

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A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

1990 • 431 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site

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1992 • 311 citations

Complex role of matrix metalloproteinases in angiogenesis

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Matrix Metalloproteinase 7 (Matrilysin) from Human Rectal Carcinoma Cells

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The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

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Isolation and characterization of a low-molecular-weight substance activating head and bud formation in hydra

1973 • 154 citations

Budhead,a Fork Head/HNF-3 Homologue, Is Expressed during Axis Formation and Head Specification in Hydra

1997 • 150 citations

Plasma Membrane-bound Tissue Inhibitor of Metalloproteinases (TIMP)-2 Specifically Inhibits Matrix Metalloproteinase 2 (Gelatinase A) Activated on the Cell Surface

1998 • 149 citations

Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila

1995 • 143 citations

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1992 • 142 citations

The Helping Hand of Collagenase-3 (MMP-13): 2.7 Å Crystal Structure of its C-terminal Haemopexin-like Domain

1996 • 137 citations

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Extracellular matrix (mesoglea) of Hydra vulgaris

1991 • 117 citations

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1995 • 103 citations

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1996 • 101 citations

The C‐terminal (haemopexin‐like) domain structure of human gelatinase A (MMP2): structural implications for its function

1996 • 94 citations

Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain

1995 • 90 citations

Cloning and Biological Function of Laminin in Hydra vulgaris

1994 • 87 citations

The Propeptide Domain of Membrane Type 1 Matrix Metalloproteinase Is Required for Binding of Tissue Inhibitor of Metalloproteinases and for Activation of Pro-gelatinase A

1998 • 85 citations

Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases

1992 • 85 citations

Response to insulin and the expression pattern of a gene encoding an insulin receptor homologue suggest a role for an insulin-like molecule in regulating growth and patterning in Hydra

1996 • 84 citations

Identification and characterization of hydra metalloproteinase 2 (HMP2): a meprin-like astacin metalloproteinase that functions in foot morphogenesis

2000 • 78 citations

Proteinases and restenosis in the human coronary artery: extracellular matrix production exceeds the expression of proteolytic activity

1995 • 78 citations

Extracellular Matrix (Mesoglea) of Hydra vulgaris

1993 • 71 citations

Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases

1998 • 69 citations

Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis

1995 • 67 citations

Sequencing and Characterization of the Soybean Leaf Metalloproteinase

1992 • 62 citations

Hydra Cell Aggregate Development Is Blocked by Selective Fragments of Fibronectin and Type IV Collagen

1994 • 62 citations

BMP‐1 and the astacin family of metalloproteinases: A potential link between the extracellular matrix, growth factors and pattern formation

1996 • 62 citations

Molecular Crosstalk Between Adhesion Receptors and Proteolytic Cascades in Vascular Remodelling

1997 • 60 citations

A 25.7×103Mr hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function

1995 • 60 citations

The novel signal peptides, Pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra

1999 • 59 citations

Isolation and characterization of two new morphogenetically active peptides from Hydra vulgaris

1996 • 55 citations

Chapter 18 Transdifferentiation Occurs Continuously in Adult Hydra

1986 • 54 citations

Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in Escherichia coli: Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1)

1998 • 50 citations

Effects of oligonucleotide length, mismatches and mRNA levels on C-5 propyne-modified antisense potency

1996 • 50 citations

Extracellular matrix (mesoglea) of Hydra vulgaris

1991 • 49 citations

Characterization of Rat Uterine Matrilysin and Its cDNA

1995 • 46 citations

Cell-extracellular matrix interactions under in vivo conditions during interstitial cell migration in Hydra vulgaris

1994 • 43 citations

Sea Urchin Hatching Enzyme (Envelysin): cDNA Cloning and Deprivation of Protein Substrate Specificity by Autolytic Degradation^,,

1997 • 43 citations

Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos

1997 • 41 citations

The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian matrix metalloproteinase family

1991 • 37 citations

Neuronal control of development in hydra.

1996 • 32 citations

Stimulation of Tentacle and Bud Formation by the Neuropeptide Head Activator inHydra magnipapillata

1997 • 29 citations

Structure of the sea urchin hatching enzyme gene

1994 • 28 citations

Characterization of the 46-kDa Intermediates of Matrix Metalloproteinase 3 (Stromelysin 1) Obtained by Site-directed Mutation of Phenylalanine 83

1996 • 27 citations

The Astacins: structure and function of a new protein family

1997 • 19 citations

Head formation at the basal end and mirror-image pattern duplication in Hydra vulgaris.

1996 • 16 citations