3-hydroxy-3-methylglutaryl coenzyme A reductase in human liver microsomes: active and inactive forms and cross-reactivity with antibody against rat liver enzyme.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol

1973 • 309 citations

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

1979 • 309 citations

Interconversion of active and inactive forms of rat liver hydroxymethylglutaryl-CoA reductase.

1977 • 231 citations

Hepatic Cholesterol Metabolism in Patients with Gallstones

1975 • 168 citations

Effect of chenodeoxycholic acid and phenobarbital on the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in patients with gallstones.

1976 • 162 citations

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

1982 • 147 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.

1978 • 143 citations

Hepatic cholesterol and bile acid metabolism in subjects with gallstones: comparative effects of short erm feeding of chenodeoxycholic and ursodeoxycholic acid.

1980 • 119 citations

Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity.

1980 • 118 citations

Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and biliary lipid composition in man: relation to cholesterol gallstone disease and effects of cholic acid and chenodeoxycholic acid treatment

1981 • 104 citations

Reversible modulation of liver hydroxymethylglutaryl CoA reductase

1978 • 97 citations

Hepatic HMGCoA reductase in human cholelithiasis: effects of chenodeoxycholic and ursodeoxycholic acids*

1980 • 76 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase from rat liver. Its purification, properties, and immunochemical studies.

1976 • 72 citations

Hepatic cholesterol metabolism in obesity: activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1982 • 64 citations

Ursodeoxycholic acid treatment in cholesterol gallstone disease: effects on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, biliary lipid composition, and plasma lipid levels

1983 • 59 citations

Proteinase involvement in the solubilization of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1981 • 57 citations

Regulation of vertebrate liver HMG-CoA reductase via reversible modulation of its catalytic activity

1980 • 56 citations

In vitro phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme a reductase: Analysis of 32P-labeled, inactivated enzyme

1979 • 55 citations

In vivo and in vitro mechanisms regulating rat liver beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity.

1980 • 52 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in minimal deviation hepatoma 7288C. Immunological measurements in hepatoma tissue culture cells.

1977 • 46 citations

Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.

1979 • 44 citations

In vivo effect of cholesterol feeding on the short term regulation of hepatic hydroxymethylglutaryl coenzyme A reductase during the diurnal cycle.

1981 • 42 citations

Immunotitration of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in various physiological states.

1979 • 29 citations

Modification of 3-hydroxy-3-methylglutaryl coenzyme A reductase immunoinhibition curves by substrates and inhibitors. Evidence for conformational changes leading to alterations in antigenicity.

1982 • 28 citations

Regulation of Short‐Term Changes in Hepatic β‐Hydroxy‐β‐methylglutaryl‐CoA Reductase Activity

1982 • 27 citations

3-Hydroxy-3-methylglutaryl-CoA reductase: solubilization in the presence of proteolytic inhibitors, partial purification, and reversible phosphorylation-dephosphorylation

1983 • 21 citations

Preparation of highly radioactive homogeneous 32P-labeled hydroxymethylglutaryl coenzyme a reductase from rat liver

1981 • 17 citations

Purification of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver.

1982 • 17 citations

Production and characterization of monoclonal antibodies to rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 16 citations

Analytical fractionation of human liver microsomal fractions: Localization of cholesterol and of the enzymes relevant to its metabolism

1981 • 13 citations

Isolation and immunological characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver

1982 • 8 citations

Development of monoclonal antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1982 • 3 citations

Deleted Work

1955 • 0 citations