3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Phosphorylated Proteins as Physiological Effectors

1978 • 975 citations

The isolation of IgG from mammalian sera with the aid of caprylic acid

1969 • 874 citations

Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol

1974 • 502 citations

Micro assay for 3-hdyroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts

1974 • 408 citations

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

1973 • 348 citations

Regulation of Hepatic Acetyl Coenzyme A Carboxylase by Phosphorylation and Dephosphorylation

1973 • 337 citations

Inhibition of Sterol Synthesis in Cultured Mouse Cells by Cholesterol Derivatives Oxygenated in the Side Chain

1974 • 330 citations

Inhibition of Sterol Synthesis in Cultured Mouse Cells by 7α-Hydroxycholesterol, 7β-Hydroxycholesterol, and 7-Ketocholesterol

1973 • 320 citations

Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol

1973 • 309 citations

3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

1973 • 240 citations

Interconversion of active and inactive forms of rat liver hydroxymethylglutaryl-CoA reductase.

1977 • 231 citations

Metabolic Regulation by Chemical Modification of Enzymes

1971 • 165 citations

Evidence that a phosphorylated intermediate in a brain transport adenosine triphosphatase is an acyl phosphate.

1965 • 161 citations

The Effect of Cholesterol Feeding and Fasting upon β-Hydroxy-β-methylglutaryl Coenzyme A Reductase

1967 • 161 citations

Regulation of Hepatic 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

1972 • 154 citations

Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in hepatoma tissue culture cells by pure cholesterol and several cholesterol derivatives. Evidence supporting two distinct mechanisms.20l.

1976 • 149 citations

Stimulation by insulin of rat liver β-hydroxy-β-methylglutaryl coenzyme A reductase and cholesterol-synthesizing activities

1973 • 131 citations

Enzymatic Interconversion of Active and Inactive Forms of Enzymes

1973 • 116 citations

Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo.

1977 • 110 citations

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.

1975 • 98 citations

Regulation of Rat Liver β-Hydroxy-β-Methylglutaryl-CoA Reductase Activity by Cholesterol

1973 • 97 citations

Control of sterol synthesis and of hydroxymethylglutaryl CoA reductase in skin fibroblasts grown from patients with homozygous type II hyperlipoproteinemia

1975 • 75 citations

Regulatory Effects of Nicotinamide on Tryptophan Pyrrolase Synthesis in Rat Liver in vivo

1968 • 57 citations

Properties and regulation of liver phosphorylase phosphatase

1976 • 56 citations

Cholesterol synthesis by cultured fibroblasts: decreased feedback inhibition in familial hypercholesterolemia.

1974 • 48 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in minimal deviation hepatoma 7288C. Immunological measurements in hepatoma tissue culture cells.

1977 • 46 citations

Purification and characterization of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase from chicken liver

1977 • 37 citations

Regulation of cholesterol synthesis in normal and malignant tissue.

1973 • 36 citations

Specific Activation of in Vitro Cholesterol Biosynthesis by Preincubation of Rat Liver Homogenates

1973 • 35 citations

The inhibitory effect of ATP on HMGCoA reductase

1975 • 25 citations

Evidence for an activating-inactivating system of 3-hydroxy-3-methylglutaryl-CoA reductase in mouse liver.

1974 • 11 citations

Solubilization of 3-hydroxy-3-methylglutaryl coenzyme A reductase from rat and chicken liver microsomes

1978 • 8 citations