Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

Enzymic determination of <scp>d</scp>(−)-β-hydroxybutyric acid and acetoacetic acid in blood

1962 • 1,407 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol

1973 • 309 citations

Regulation of Hepatic 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Synthesis

1971 • 252 citations

Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues* *This research was supported by U. S. Public Health Service Grants CA-08501, CA-05200, and Research Career Award HE-01958, and by the Damon Runyon Memorial Fund Award No. 747.

1970 • 232 citations

Interconversion of active and inactive forms of rat liver hydroxymethylglutaryl-CoA reductase.

1977 • 231 citations

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis

1974 • 161 citations

Ketone Body Metabolism in the Ketosis of Starvation and Alloxan Diabetes

1970 • 159 citations

Regulation of Cholesterol Metabolism

1970 • 151 citations

Limitations of Acetate as a Substrate for Measuring Cholesterol Synthesis in Liver

1974 • 144 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.

1978 • 143 citations

Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme a reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation

1978 • 142 citations

Turnover Rate of Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase as Determined by Use of Cycloheximide

1972 • 136 citations

Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase

1972 • 111 citations

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.

1975 • 98 citations

Reversible modulation of liver hydroxymethylglutaryl CoA reductase

1978 • 97 citations

Regulation of Rat Liver β-Hydroxy-β-Methylglutaryl-CoA Reductase Activity by Cholesterol

1973 • 97 citations

Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton.

1977 • 90 citations

Dephosphorylation of phosphoproteins by Escherichia coli alkaline phosphatase.

1977 • 64 citations

Rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase: A comparison and immunological study of purified solubilized preparations, and alteration of enzyme levels by cholestyramine feeding

1974 • 62 citations

High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit.

1978 • 54 citations

The interaction of various control mechanisms in determining the rate of hepatic cholesterogenesis in the rat

1975 • 43 citations