Anti-retroviral therapy of human immunodeficiency virus infection: current strategies and challenges for the future [published erratum appears in Blood 1991 Dec 15;78(12):3330]

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

1986 • 1,348 citations

Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

1990 • 1,307 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line

1987 • 936 citations

Rational Design of Peptide-Based HIV Proteinase Inhibitors

1990 • 910 citations

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1990 • 899 citations

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

1990 • 845 citations

ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

1986 • 806 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

6-Mercaptopurine in the Management of Inflammatory Bowel Disease: Short- and Long-Term Toxicity

1989 • 757 citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1990 • 749 citations

Molecular Targets for AIDS Therapy

1990 • 736 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

1987 • 569 citations

Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase

1991 • 566 citations

Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus

1988 • 532 citations

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

1988 • 532 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

1987 • 530 citations

PHASE I STUDIES OF 2',3'-DIDEOXYCYTIDINE IN SEVERE HUMAN IMMUNODEFICIENCY VIRUS INFECTION AS A SINGLE AGENT AND ALTERNATING WITH ZIDOVUDINE (AZT)

1988 • 513 citations

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6.

1990 • 500 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

Persistent B19 Parvovirus Infection in Patients Infected with Human Immunodeficiency Virus Type 1 (HIV-1): A Treatable Cause of Anemia in AIDS

1990 • 482 citations

Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry

1988 • 462 citations

Hypertriglyceridemia in the acquired immunodeficiency syndrome

1989 • 446 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

1990 • 437 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Drug-induced pancreatitis: A critical review

1980 • 401 citations

Retroviral DNA integration: Structure of an integration intermediate

1988 • 397 citations

Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.

1989 • 392 citations

Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A Novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

1987 • 383 citations

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

1990 • 382 citations

High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients

1990 • 376 citations

Infection and Replication of HIV-1 in Purified Progenitor Cells of Normal Human Bone Marrow

1988 • 375 citations

Infection of the SCID-hu Mouse by HIV-1

1988 • 368 citations

Clinical Pharmacology of 3'-Azido-2',3'-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides

1989 • 356 citations

RESPONSE OF HUMAN-IMMUNODEFICIENCY-VIRUS-ASSOCIATED NEUROLOGICAL DISEASE TO 3'-AZIDO-3'-DEOXYTHYMIDINE

1987 • 352 citations

Recombinant Human Erythropoietin for Patients with AIDS Treated with Zidovudine

1990 • 347 citations

Retroviral DNA Integration Directed by HIV Integration Protein in Vitro

1990 • 346 citations

Specific Tropism of HIV-1 for Microglial Cells in Primary Human Brain Cultures

1990 • 343 citations

Angiogenic Properties of Kaposi's Sarcoma-Derived Cells After Long-Term Culture in Vitro

1988 • 335 citations

Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.

1987 • 331 citations

Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro

1987 • 320 citations

On the Mechanism of Thrombocytopenic Purpura in Sexually Active Homosexual Men

1984 • 311 citations

Ribavirin Antagonizes the Effect of Azidothymidine on HIV Replication

1987 • 282 citations

Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T Cells

1988 • 265 citations

Potent and selective in vitro activity of 3' -deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus

1987 • 260 citations

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1988 • 253 citations

Once-Daily Administration of 2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 253 citations

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon

1987 • 237 citations

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

1990 • 234 citations

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

1990 • 217 citations

Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus

1987 • 208 citations

Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.

1989 • 207 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Prolonged Zidovudine Therapy in Patients With AIDS and Advanced AIDS-Related Complex

1989 • 200 citations

Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies

1990 • 199 citations

Anti-retrovirus activity of 3′-fluoro- and 3′-azido-substituted pyrimidine 2′,3′-dideoxynucleoside analogues

1988 • 188 citations

Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy

1990 • 180 citations

Biological properties of a CD4 immunoadhesin

1990 • 176 citations

Megakaryocytes of human immunodeficiency virus-infected individuals express viral RNA.

1989 • 171 citations

Azidothymidine Associated with Bone Marrow Failure in the Acquired Immunodeficiency Syndrome (AIDS)

1987 • 168 citations

Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro.

1988 • 158 citations

CD4 Count and the Risk for Death in Patients Infected with HIV Receiving Antiretroviral Therapy

1991 • 157 citations

Structure and expression of the human and mouse T4 genes.

1987 • 155 citations

HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor

1990 • 145 citations

Initial studies on the cellular pharmacology of 2′,3′-dideoxyinosine, an inhibitor of HIV infectivity

1987 • 142 citations

HIV-Infected Cells Are Killed by rCD4-Ricin A Chain

1988 • 141 citations

In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and gamma interferon.

1986 • 133 citations

Effects of 2′,3′‐dideoxynucleosides on mammalian cells and viruses

1984 • 127 citations

Induction of Endogenous Virus and of Thymidine Kinase by Bromodeoxyuridine in Cell Cultures Transformed by Friend Virus

1974 • 122 citations

Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex

1989 • 118 citations

Inhibition of HTLV-III/LAV replication by foscarnet

1985 • 114 citations

Cytokines alter production of HIV-1 from primary mononuclear phagocytes

1988 • 111 citations

Cancer among New York men at risk of acquired immunodeficiency syndrome

1989 • 108 citations

Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome.

1988 • 106 citations

Anemia and Erythropoiesis in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and Kaposi Sarcoma Treated with Zidovudine

1988 • 105 citations

PROBENECID AND ZIDOVUDINE METABOLISM

1989 • 101 citations

Pharmacokinetics of 2‘,3’‐Dideoxycytidine in Patients with AIDS and Related Disorders

1988 • 101 citations

Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro

1987 • 87 citations

Broad spectrum antiretroviral activity of 2',3'-dideoxynucleosides.

1987 • 87 citations

Adenallene and cytallene: acyclic-nucleoside analogues that inhibit replication and cytopathic effect of human immunodeficiency virus in vitro.

1988 • 75 citations

Partial Immune Reconstitution in a Patient with the Acquired Immunodeficiency Syndrome

1984 • 72 citations

Antiretroviral Therapy in AIDS

1990 • 71 citations

5-Fluorouracil enhances azidothymidine cytotoxicity: in vitro, in vivo, and biochemical studies.

1990 • 66 citations

Dermatologic complications associated with administration of 2′,3′-dideoxycytidine in patients with human immunodeficiency virus infection

1989 • 62 citations

Synergistic Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication In Vitro by Recombinant Soluble CD4 and 3'-Azido-3'-Deoxythymidine

1989 • 60 citations

Inhibition of duck hepatitis B virus replication by 2′,3′-dideoxycytidine

1989 • 58 citations

Survival trends for patients with AIDS

1990 • 55 citations

Perspectives for the chemotherapy of AIDS.

1987 • 54 citations

Inhibition of Growth of HIV by Human Natural Interferon In Vitro

1988 • 50 citations

Relative inefficiency of soluble recombinant CD4 for inhibition of infection by monocyte-tropic HIV in monocytes and T cells.

1990 • 50 citations

In vitro inhibition of the infectivity and replication of human immunodeficiency virus type 1 by combination of antiretroviral 2',3'-dideoxynucleosides and virus-binding inhibitors

1990 • 49 citations

Pancreatitis associated with pentamidine by aerosol.

1989 • 46 citations

Pharmacodynamics of 2′,3′-dideoxycytidine: An inhibitor of human immunodeficiency virus

1990 • 40 citations

Adenine Toxicity: A Three Week Intravenous Study in Dogs

1973 • 36 citations

Increase in intracisternal A-type particles in Friend cells during inhibition of Friend virus (SFFV) release by interferon or azidothymidine

1978 • 32 citations

Inhibition of Serum-Enhanced HIV-1 Infection of U937 Monocytoid Cells by Recombinant Soluble CD4 and Anti-CD4 Monoclonal Antibody

1990 • 31 citations

Ability of Anti-HIV Agents to Inhibit HIV Replication in Monocyte/Macrophages or U937 Monocytoid Cells Under Conditions of Enhancement by GM-CSF or Anti-HIV Antibody

1990 • 29 citations

Phase I Clinical Investigation of Fludarabine Phosphate by a Loading-Dose and Continuous-Infusion Schedule

1988 • 24 citations

The effect of acetaminophen on zidovudine metabolism in HIV-infected patients.

1990 • 20 citations

Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy

1986 • 16 citations

Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection

1989 • 16 citations

Treatment of Human Immunodeficiency Virus Infections

1987 • 11 citations

Human immunodeficiency virus infection and cervical neoplasia

1991 • 10 citations

In vivo activity against HIV and favorable toxicity profile of 2′,3′-dideoxyinosine

1989 • 9 citations

The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells

1989 • 8 citations

4868119 Hematopoietic growth factors

1990 • 7 citations

New Developments in Combination Chemotherapy of Anti‐Human Immunodeficiency Virus Drugs

1990 • 5 citations

Burkitt's lymphoma in AIDS: cytogenetic study

1984 • 5 citations

Human T-Lymphotropic Viruses

2017 • 2 citations

Cellular metabolism of 2', 3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro.

1987 • 2 citations

Cited By (0)

Loading...