The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability.

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

1997 • 959 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Progressive lineage analysis by cell sorting and culture identifies FLK1+VEcadherin+ cells at a diverging point of endothelial and hemopoietic lineages

1998 • 830 citations

Tight junctions and the molecular basis for regulation of paracellular permeability

1995 • 825 citations

Cadherin-catenin complex: Protein interactions and their implications for cadherin function

1996 • 806 citations

Endothelial Claudin

1999 • 802 citations

Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands

1999 • 724 citations

MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS

1998 • 718 citations

Developmental Defects in Mouse Embryos Lacking N-Cadherin

1997 • 712 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

Differentiation of endothelium

1995 • 617 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

1995 • 573 citations

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

1998 • 566 citations

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

1998 • 532 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS

1998 • 526 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

Endothelial cell‐to‐cell junctions

1995 • 481 citations

In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.

1995 • 416 citations

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

1994 • 405 citations

Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis.

1996 • 372 citations

A role for cadherins in tissue formation

1996 • 355 citations

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

1996 • 353 citations

Cadherins and catenins in development

1996 • 344 citations

Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer

1998 • 343 citations

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.

1996 • 335 citations

Molecular cloning and expression of murine vascular endothelial- cadherin in early stage development of cardiovascular system

1996 • 325 citations

Role of vascular endothelial-cadherin in vascular morphogenesis

1999 • 311 citations

Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)

1999 • 288 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells

1997 • 285 citations

Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin

1995 • 273 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

1994 • 228 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Catenin-dependent and -independent Functions of Vascular Endothelial Cadherin

1995 • 220 citations

Interendothelial junctions: structure, signalling and functional roles

1997 • 219 citations

An α- E-catenin gene trap mutation defines its function in preimplantation development

1997 • 214 citations

The role of beta-catenin in cell adhesion, signal transduction, and cancer

1998 • 196 citations

Two classes of tight junctions are revealed by ZO-1 isoforms

1993 • 189 citations

Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin).

1996 • 187 citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

1994 • 179 citations

The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity

1998 • 173 citations

Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.

1990 • 166 citations

Cross Talk between Adhesion Molecules: Control of N-cadherin Activity by Intracellular Signals Elicited by β1 and β3 Integrins in Migrating Neural Crest Cells

1997 • 155 citations

A Versatile Transcriptional Effector of Wingless Signaling

1997 • 147 citations

VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: A pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions

1998 • 129 citations

Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis

1997 • 127 citations

Requirement of a GT Box (Sp1 Site) and Two Ets Binding Sites for Vascular Endothelial Cadherin Gene Transcription

1998 • 116 citations

Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: II. Different types of lymphatic vessels

1994 • 107 citations

Direct Involvement of N-Cadherin–mediated Signaling in Muscle Differentiation

1998 • 82 citations

Desmoplakin expression and organization at human umbilical vein endothelial cell-to-cell junctions

1996 • 76 citations

Genomic structure and chromosomal mapping of the mouse N-cadherin gene.

1992 • 68 citations

Genomic Structure and Chromosomal Mapping of the Mouse VE-Cadherin Gene (Cdh5)

1996 • 51 citations

Cadherin Transfection of Xenopus XTC Cells Downregulates Expression of Substrate Adhesion Molecules

1995 • 44 citations

Identification of the promoter and a transcriptional enhancer of the gene encoding L-CAM, a calcium-dependent cell adhesion molecule.

1993 • 23 citations

Complex Cell Type‐Specific Transcriptional Regulation by the Promoter and an Intron of the Mouse P‐Cadherin Gene

1994 • 11 citations