The influence of 5′ and 3′ end structures on pre-mRNA metabolism

Messenger RNA degradation in eukaryotes

1993 • 858 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Do the poly(A) tail and 3′ untranslated region control mRNA translation?

1990 • 618 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

5′-Terminal structure and mRNA stability

1977 • 542 citations

A nuclear cap binding protein complex involved in pre-mRNA splicing

1994 • 506 citations

Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylationin vitro

1990 • 498 citations

COMPLEX TRANSCRIPTIONAL UNITS: DIVERSITY IN GENE EXPRESSION BY ALTERNATIVE RNA PROCESSING

1986 • 486 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

Structure of spliceosomal snRNPs and their role in pre-mRNA splicing

1990 • 407 citations

THE BIOCHEMISTRY OF 3′-END CLEAVAGE AND POLYADENYLATION OF MESSENGER RNA PRECURSORS

1992 • 387 citations

In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes.

1993 • 361 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA.

1989 • 314 citations

An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

1991 • 297 citations

A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation

1991 • 286 citations

General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 • 286 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation

1988 • 266 citations

Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing

1994 • 261 citations

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle

1988 • 256 citations

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.

1990 • 243 citations

The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location.

1994 • 236 citations

Four factors are required for 3'-end cleavage of pre-mRNAs.

1989 • 217 citations

The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase

1994 • 209 citations

Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3′ processing signal AAUAAA.

1991 • 207 citations

The human U1 snRNP-Specific U1A protein inhibits polyadenylation of its own pre-mRNA

1993 • 206 citations

Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.

1991 • 200 citations

An ordered pathway of assembly of components required for polyadenylation site recognition and processing.

1989 • 194 citations

Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis.

1977 • 179 citations

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

1993 • 173 citations

Purification of the cleavage and polyadenylation factor involved in the 3'-processing of messenger RNA precursors.

1991 • 172 citations

Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus.

1992 • 170 citations

The addition of 5′ cap structures occurs early in hnRNA synthesis and prematurely terminated molecules are capped

1980 • 161 citations

SR proteins can compensate for the loss of U1 snRNP functions in vitro.

1994 • 160 citations

Cap-dependent RNA splicing in a HeLa nuclear extract.

1985 • 156 citations

Who's on first? The U1 snRNP-5 splice site interaction and splicing

1991 • 156 citations

Primary structure and expression of bovine poly(A) polymerase

1991 • 155 citations

In the beginning is the end: regulation of poly(A) addition and removal during early development

1990 • 153 citations

Complementation by SR Proteins of Pre-mRNA Splicing Reactions Depleted of U1 snRNP

1994 • 152 citations

A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs.

1992 • 150 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

3′-End cleavage and polyadenylation of mRNA precursors

1995 • 136 citations

Isolation and expression of cDNA clones encoding mammalian poly(A) polymerase.

1991 • 129 citations

Association with terminal exons in pre-mRNAs: a new role for the U1 snRNP?

1993 • 121 citations

A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation.

1993 • 118 citations

Surprises at the 3′ end of prokaryotic RNA

1995 • 112 citations

Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA.

1991 • 111 citations

mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae.

1992 • 109 citations

Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro.

1989 • 104 citations

Two phases in the addition of a poly(A) tail.

1989 • 98 citations

Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases.

1994 • 97 citations

Transport of RNA between nucleus and cytoplasm

1992 • 93 citations

Effect of the cap structure on pre-mRNA splicing in Xenopus oocyte nuclei.

1989 • 83 citations

A nuclear cap binding protein from HeLa cells

1990 • 78 citations

Non-snRNP protein splicing factors

1993 • 71 citations

Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals

1994 • 64 citations

CAP binding proteins associated with the nucleus

1983 • 54 citations

Assembly of pre-mRNA splicing complex is cap dependent

1987 • 52 citations

Identification of nuclear cap specific proteins in HeLa cells

1987 • 45 citations

Poly(A) Polymerase Purified from HeLa Cell Nuclear Extract Is Required for Both Cleavage and Polyadenylation of Pre-mRNA In Vitro

1989 • 40 citations

Small nuclear RNAs and pre-mRNA splicing

1994 • 31 citations

Association of poly(A) polymerase with U1 RNA.

1988 • 15 citations