In the beginning is the end: regulation of poly(A) addition and removal during early development

Methods in Enzymology , Vol

1966 • 26,261 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Use of Frog Eggs and Oocytes for the Study of Messenger RNA and its Translation in Living Cells

1971 • 774 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Sex in flies: the splice of life

1989 • 468 citations

Model for the regulation of mRNA translation applied to haemoglobin synthesis

1974 • 416 citations

Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.

1989 • 412 citations

How the messenger got its tail: addition of poly(A) in the nucleus

1990 • 390 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

mRNA poly(A) tail, a 3' enhancer of translational initiation.

1990 • 353 citations

Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.

1989 • 332 citations

Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte

1989 • 291 citations

Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima

1980 • 281 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

Glucocorticoids enhance stability of human growth hormone mRNA.

1987 • 250 citations

Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes.

1989 • 248 citations

The effect of capping and polyadenylation on the stability, movement and translation of synthetic messenger RNAs inXenopusoocytes

1985 • 231 citations

Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA.

1987 • 211 citations

Translation Initiation and Ribosomal Biogenesis: Involvement of a Putative rRNA Helicase and RPL46

1990 • 204 citations

Sequence-specific adenylations and deadenylations accompany changes in the translation of maternal messenger RNA after fertilization of Spisula oocytes

1983 • 190 citations

Antisense RNA Directed Against the 3′ Noncoding Region Prevents Dormant mRNA Activation in Mouse Oocytes

1988 • 174 citations

Expression of a histone H1-like protein is restricted to early Xenopus development.

1988 • 174 citations

Vasopressin mRNA in the Suprachiasmatic Nuclei: Daily Regulation of Polyadenylate Tail Length

1988 • 172 citations

The role of cyclin synthesis, modification and destruction in the control of cell division

1989 • 154 citations

Xfin: an embryonic gene encoding a multifingered protein in Xenopus.

1987 • 139 citations

Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA

1988 • 138 citations

Protein synthesis in oocytes of xenopus laevis is not regulated by the supply of messenger RNA

1977 • 117 citations

Role of the 3'-poly(A) sequence in translational regulation of mRNAs in Xenopus laevis oocytes.

1988 • 113 citations

Differential capacity for translation and lack of competition between mRNAs that segregate to free and membrane-bound polysomes

1981 • 113 citations

Translational inactivation of ribosomal protein mRNAs during Xenopus oocyte maturation.

1988 • 106 citations

Translational Regulation of Gene Expression

1987 • 102 citations

Two phases in the addition of a poly(A) tail.

1989 • 98 citations

Changes in RNA titers and polyadenylation during oogenesis and oocyte maturation in Xenopus laevis

1985 • 89 citations

Processing of 9E3 mRNA and regulation of its stability in normal and Rous sarcoma virus-transformed cells.

1989 • 86 citations

Changes in the polyadenylation of specific stable RNA during the early development of Xenopus laevis

1988 • 85 citations

Regulation of insulin mRNA abundance and adenylation: dependence on hormones and matrix substrata.

1986 • 76 citations

Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation.

1989 • 65 citations

Molecular Aspects of Early Development

1984 • 64 citations

Destruction of a translationally controlled mRNA in Xenopus oocytes delays progesterone-induced maturation.

1988 • 48 citations