The Absence of Ongoing Immunoglobulin Gene Hypermutation Suggests a Distinct Mechanism for c-myc Mutation in Endemic Burkittʼs Lymphoma

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

1986 • 834 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

The role of gene dosage and genetic transpositions in carcinogenesis

1981 • 670 citations

Induction of Immune Responses in Patients with B-Cell Lymphoma against the Surface-Immunoglobulin Idiotype Expressed by Their Tumors

1992 • 551 citations

Translocation and Rearrangements of the c- myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas

1983 • 514 citations

Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma.

1986 • 371 citations

Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells

1984 • 335 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Organization of human immunoglobulin heavy chain diversity gene loci.

1988 • 317 citations

Molecular Basis of Human B Cell Neoplasia

1985 • 316 citations

Pathogenesis of Burkitt lymphoma: Expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts

1987 • 302 citations

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma

1983 • 286 citations

PCR-based cDNA library construction: general cDNA libraries at the level of a few cells

1989 • 285 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma

1984 • 259 citations

Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression

1986 • 254 citations

Sequence requirements for premature termination of transcription in the human c-myc gene

1988 • 246 citations

Molecular basis of human B cell neoplasia

1985 • 244 citations

Clusters of point mutations are found exclusively around rearranged antibody variable genes.

1983 • 233 citations

Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt Lymphoma

1987 • 228 citations

Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

1993 • 222 citations

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

1988 • 177 citations

American Burkitt's lymphoma: A clinicopathologic study of 30 cases

1975 • 166 citations

Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia.

1988 • 160 citations

Distribution of Mutations around Rearranged Heavy-Chain Antibody Variable-Region Genes

1990 • 129 citations

A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) burkitt lymphoma

1984 • 122 citations

Activation of a translocated c-myc gene: role of structural alterations in the upstream region.

1984 • 122 citations

Idiotype vaccination against murine B cell lymphoma. Humoral and cellular responses elicited by tumor-derived immunoglobulin M and its molecular subunits.

1987 • 118 citations

Cloning and sequencing of a c-myc oncogene in a Burkitt's lymphoma cell line that is translocated to a germ line alpha switch region.

1985 • 114 citations

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity

1995 • 114 citations

Transcription enhancer identified near the human Cμ immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma

1983 • 97 citations

Transcriptional and post-transcriptional regulation of c-mye expression during the differentiation of murine erythroleukemia Friend cells

1986 • 97 citations

The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.

1990 • 96 citations

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

1990 • 93 citations

Somatic mutation gains its place among the generators of diversity

1981 • 84 citations

Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver

1993 • 81 citations

Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement.

1985 • 73 citations

Somatic Mutations of Immunoglobulin Variable Genes Are Restricted to the Rearranged V Gene

1983 • 63 citations

A translocated human c-myc oncogene is altered in a conserved coding sequence.

1986 • 55 citations

Idiotype variant cell populations in patients with B cell lymphoma.

1986 • 52 citations

MYC oncogene involved in a t(8;22) chromosome translocation is not altered in its putative regulatory regions.

1987 • 48 citations

Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma.

1989 • 48 citations

Clustered somatic mutations in and around first exon of non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation

1987 • 33 citations

Chromosome translocation activates heterogeneously initiated, bipolar transcription of a mouse c-myc gene.

1985 • 29 citations

Trasiocation affects normalc-mycpromoter usage and activates fifteen crypticc-myctranscription starts in plasmacytoma M603

1984 • 25 citations

Somatic mutation and transcriptional deregulation of myc in endemic Burkitt's lymphoma disease: heptamer-nonamer recognition mistakes?

1989 • 23 citations

Sequence analysis of non-expressed immunoglobulin heavy chain loci in clonally related, somatically mutated hybridoma cells.

1985 • 22 citations

c-myc hypermutation is ongoing in endemic, but not all Burkitt's lymphoma

1991 • 21 citations

Activation of cryptic promoters of human c-myc genes in microinjected Xenopus laevis oocytes

1987 • 3 citations