Human cytidine deaminase as an ex vivo drug selectable marker in gene-modified primary bone marrow stromal cells

Multilineage Potential of Adult Human Mesenchymal Stem Cells

1999 • 20,447 citations

Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues

1997 • 4,643 citations

Cardiomyocytes can be generated from marrow stromal cells in vitro

1999 • 1,910 citations

Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

1999 • 1,841 citations

Mesenchymal stem cells

2000 • 1,430 citations

Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells

2001 • 1,218 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.

1996 • 925 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes.

1991 • 489 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Marrow stromal cells for cellular cardiomyoplasty: Feasibility and potential clinical advantages

2000 • 396 citations

Immune response to green fluorescent protein: implications for gene therapy

1999 • 324 citations

A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

1990 • 313 citations

Studies of the enzymatic deamination of cytosine arabinoside—I

1965 • 296 citations

Transduction of Murine Bone Marrow Cells With an MDR1 Vector Enables Ex Vivo Stem Cell Expansion, but These Expanded Grafts Cause a Myeloproliferative Syndrome in Transplanted Mice

1998 • 197 citations

Herpes Simplex Virus Thymidine Kinase Gene Transfer for Controlled Graft-versus-Host Disease and Graft-versus-Leukemia: Clinical Follow-up and Improved New Vectors

1998 • 185 citations

Induction of cytotoxic T lymphocyte and antibody responses to enhanced green fluorescent protein following transplantation of transduced CD34+ hematopoietic cells

2001 • 146 citations

Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitutions of Leucine 22

1995 • 140 citations

Improved prospects for long-term survival in adults with acute myelogenous leukemia

1982 • 130 citations

Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

1995 • 123 citations

Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells

1995 • 122 citations

Secondary Malignancies Following Cancer Chemotherapy

1994 • 115 citations

Systemic Delivery of Human Growth Hormone or Human Factor IX in Dogs by Reintroduced Genetically Modified Autologous Bone Marrow Stromal Cells

1997 • 102 citations

The treatment of adult acute myeloid leukemia.

1997 • 94 citations

Drug resistance to 5-aza-2 ′ -deoxycytidine, 2 ′ ,2 ′ -difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells

1998 • 92 citations

Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer.

1999 • 91 citations

Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside

1983 • 89 citations

Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.

1994 • 88 citations

Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors

2000 • 84 citations

Improved Prospects for Long-term Survival in Adults With Acute Myelogenous Leukemia

1982 • 82 citations

Gene transfer into normal human hematopoietic cells using in vitro and in vivo assays

1991 • 82 citations

Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells: effect of selectable marker sequences on long-term expression

1991 • 77 citations

Bone Marrow Stromal Cells as Targets for Gene Therapy of Hemophilia A

1998 • 75 citations

Bone marrow stromal cells as a vehicle for gene transfer

1999 • 71 citations

Genetic delivery of enzymes for cancer therapy.

1995 • 70 citations

Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA.

1994 • 64 citations

Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells.

1979 • 56 citations

Resistance to cytosine arabinoside by retrovirally mediated gene transfer of human cytidine deaminase into murine fibroblast and hematopoietic cells.

1996 • 55 citations

Humoral immune response limits gene therapy in canine MPS I [letter]

1996 • 44 citations

Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice.

1997 • 43 citations

Glucocorticoid-Inducible Retrovector for Regulated Transgene Expression in Genetically Engineered Bone Marrow Stromal Cells

2000 • 34 citations

Selection of Keratinocytes Transduced with the Multidrug Resistance Gene in an in Vitro Skin Model Presents a Strategy for Enhancing Gene Expression in Vivo

1999 • 33 citations

Humoral immune response limits gene therapy in canine MPS I.

1996 • 32 citations

Transfection of murine fibroblast cells with human cytidine deaminase cDNA confers resistance to cytosine arabinoside

1996 • 29 citations

Retroviral transfer and long-term expression of human cytidine deaminase cDNA in hematopoietic cells following transplantation in mice

1998 • 29 citations

A Phase I Study of the Transplantation of Genetically Marked Autologous Bone Marrow Stromal Cells. University of Toronto, Ontario, Canada

1998 • 28 citations

Induction of cytidine deaminase in HL-60 myeloid leukemic cells by 5-AZA-2′-deoxycytidine

1990 • 26 citations

Retroviral Transduction of Human CD34⁺Umbilical Cord Blood Progenitor Cells with a Mutated Dihydrofolate Reductase cDNA

1998 • 22 citations

Loss of retroviral gene expression in bone marrow reconstituted mice correlates with down-regulation of gene expression in long-term culture initiating cells

1997 • 20 citations

Development of Murine Leukemia Virus-Based Self-Activating Vectors That Efficiently Delete the Selectable Drug Resistance Gene during Reverse Transcription

1999 • 17 citations

In VitroSelection of Lentivirus Vector-Transduced Human CD34⁺Cells

2000 • 15 citations

Selective expression of methotrexate-resistant dihydrofolate reductase (DHFR) activity in mice transduced with DHFR retrovirus and administered methotrexate.

1993 • 14 citations

Characterization and transduction of a retroviral vector encoding human interleukin-4 and herpes simplex virus-thymidine kinase for glioma tumor vaccine therapy

2000 • 11 citations

Gene-modified cells for the treatment of cancer

1995 • 10 citations

Methotrexate selectable retroviral vectors for Gaucher disease

1998 • 9 citations

Gene amplification of human cytidine deaminase proviral cDNA and increased levels of its mRNA produces enhanced drug resistance to cytosine arabinoside in retroviral-transduced murine fibroblasts

1998 • 3 citations