Drug resistance to 5-aza-2 ′ -deoxycytidine, 2 ′ ,2 ′ -difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Preclinical characteristics of gemcitabine

1995 • 280 citations

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.

1995 • 215 citations

Transfer and expression of the human multiple drug resistance gene into live mice.

1992 • 210 citations

Pilot phase l-ll study on 5-aza-2??-deoxycytidine (Decitabine) in patients with metastatic lung cancer

1997 • 209 citations

Kinetic studies on 2',2'-difluorodeoxycytidine (gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase

1993 • 186 citations

Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia

1981 • 183 citations

Clinical trial on 5-AZA-2′-deoxycytidine in patients with acute leukemia

1985 • 141 citations

Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

1990 • 141 citations

Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine.

1996 • 138 citations

Improved prospects for long-term survival in adults with acute myelogenous leukemia

1982 • 130 citations

Maximum-tolerated dose defined for single-agent gemcitabine: a phase I dose-escalation study in chemotherapy-naive patients with advanced non-small-cell lung cancer.

1997 • 129 citations

Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells

1995 • 122 citations

Molecular, cellular and animal pharmacology of 5-AZA-2′-deoxycytidine

1985 • 89 citations

Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside

1983 • 89 citations

5-Aza-2'-deoxycytidine (Decitabine) induces trilineage response in unfavourable myelodysplastic syndromes.

1993 • 89 citations

Retroviral Mediated Transfer of the Human Multidrug Resistance Gene (MDR-1) into Hematopoietic Stem Cells During Autologous Transplantation after Intensive Chemotherapy for Metastatic Breast Cancer. National Institutes of Health, Bethesda, Maryland

1994 • 80 citations

Activation of the retinoic acid receptor ?? gene by 5-aza-2???-deoxycytidine in human DLD-1 colon carcinoma cells

1997 • 68 citations

Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA.

1994 • 64 citations

Resistance to cytosine arabinoside by retrovirally mediated gene transfer of human cytidine deaminase into murine fibroblast and hematopoietic cells.

1996 • 55 citations

Constitutive overexpression of the cytidine deaminase gene confers resistance to cytosine arabinoside in vitro.

1996 • 51 citations

Transfection of murine fibroblast cells with human cytidine deaminase cDNA confers resistance to cytosine arabinoside

1996 • 29 citations

Induction of cytidine deaminase in HL-60 myeloid leukemic cells by 5-AZA-2′-deoxycytidine

1990 • 26 citations

Retrovirus-Mediated Gene Transfer of Rat GlutathioneS-Transferase Yc ConfersIn VitroResistance to Alkylating Agents in Human Leukemia Cells and in Clonogenic Mouse Hematopoietic Progenitor Cells

1996 • 23 citations

In vitro biochemical tests to evaluate the response to therapy of acute leukemia with cytosine arabinoside or 5-AZA-2'-deoxycytidine.

1987 • 20 citations