Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Replacement Therapy for Inherited Enzyme Deficiency — Macrophage-Targeted Glucocerebrosidase for Gaucher's Disease

1991 • 1,243 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism

1984 • 440 citations

Two species of lysosomal organelles in cultured human fibroblasts

1979 • 360 citations

Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus

1991 • 265 citations

Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy

1992 • 211 citations

Transfer and expression of the human multiple drug resistance gene into live mice.

1992 • 210 citations

Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells.

1992 • 190 citations

Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells.

1990 • 186 citations

Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector.

1992 • 183 citations

Dicistronic transcription units for gene expression in mammalian cells

1993 • 179 citations

Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.

1991 • 152 citations

Expression of a Human Multidrug Resistance cDNA (MDR1) in the Bone Marrow of Transgenic Mice: Resistance to Daunomycin-Induced Leukopenia

1989 • 151 citations

Biosynthesis of the lysosomal enzyme glucocerebrosidase.

1985 • 139 citations

Mutations of glucocerebrosidase: discrimination of neurologic and non-neurologic phenotypes of Gaucher disease.

1982 • 121 citations

Expression of the human multidrug transporter in insect cells by a recombinant baculovirus

1990 • 119 citations

Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.

1985 • 89 citations

High levels of human glucocerebrosidase activity in macrophages of long- term reconstituted mice after retroviral infection of hematopoietic stem cells

1992 • 82 citations

Retroviral-mediated transfer of the human glucocerebrosidase gene into cultured Gaucher bone marrow.

1992 • 76 citations

Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes

1993 • 75 citations

DETECTION OF THE DEFECT OF GAUCHER'S DISEASE AND ITS CARRIER STATE IN PERIPHERAL-BLOOD LEUCOCYTES

1970 • 72 citations

Expression of a multidrug resistance-adenosine deaminase fusion gene

1989 • 67 citations

A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells

1989 • 58 citations

Purification and characterization of a transformation-dependent protein secreted by cultured murine fibroblasts

1981 • 46 citations

Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.

1988 • 44 citations

The Molecular Biology of Gaucher Disease and the Potential for Gene Therapy

1986 • 36 citations

Retrovirus-mediated gene transfer to cystic fibrosis airway epithelial cells: effect of selectable marker sequences on long-term expression

1993 • 34 citations

Use of a Cloned Multidrug Resistance Gene for Coamplification and Overproduction of Major Excreted Protein, a Transformation-Regulated Secreted Acid Protease

1988 • 13 citations