Effects of atypical antipsychotic agents on social behavior in rodents

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Molecular pathology of schizophrenia: more than one disease process?

1980 • 1,877 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

SCH 23390—The first selective dopamine D-1 antagonist

1983 • 738 citations

Spiperone: A ligand of choice for neuroleptic receptors

1978 • 541 citations

The Neurobiology of Dopamine

1980 • 496 citations

Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

1988 • 429 citations

Biochemical profile of risperidone, a new antipsychotic.

1988 • 393 citations

The Role of Serotonin in Schizophrenia

1988 • 368 citations

Effects of Six Months of Clozapine Treatment on the Quality of Life of Chronic Schizophrenic Patients

1990 • 351 citations

Pharmacological Differentiation and Characterization of 5‐HT_1A, 5‐HT_1B, and 5‐HT_1C Binding Sites in Rat Frontal Cortex

1986 • 344 citations

Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390

1986 • 310 citations

Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: a multicentre double‐blind comparative study

1992 • 302 citations

PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11C-raclopride

1987 • 279 citations

A prospective study of clozapine in treatment-resistant schizophrenic patients

1989 • 269 citations

Molecular biology of the dopamine receptors

1991 • 247 citations

Do functional relationships exist between 5-HT1A and 5-HT2 receptors?

1990 • 232 citations

Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug

1986 • 231 citations

Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze

1989 • 228 citations

Climbing behaviour induced by apomorphine in mice: A potential model for the detection of neuroleptic activity

1978 • 181 citations

Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia

1991 • 169 citations

Clozapine, Chlorpromazine, and Placebo in Newly Hospitalized, Acutely Schizophrenic Patients

1979 • 146 citations

Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients

1989 • 120 citations

Buspirone: An Update on a Unique Anxiolytic Agent

1988 • 111 citations

The prefrontal cortex: Anatomy physiology and neurophysiology of the frontal lobe

1981 • 109 citations

Mesolimbic involvement with behavioural effects indicating antipsychotic activity

1974 • 82 citations

Autoradiographic identification and topographical analyses of high affinity serotonin receptor subtypes as a target for the novel putative anxiolytic TVX Q 7821

1985 • 77 citations

Do Negative Symptoms Respond to Pharmacological Treatment?

1989 • 66 citations

Combined serotonin‐5‐HT₂ and dopamine‐D₂ antagonism in schizophrenia: Clinical, extrapyramidal and neuroendocrine response in a preliminary study with risperidone (R 64 766)

1990 • 61 citations

A social interaction model of anxiety sensitive to acutely administered benzodiazepines

1984 • 53 citations

Ipsapirone depresses neuronal activity in the dorsal raphe nucleus and the hippocampal formation

1986 • 53 citations

Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.

1983 • 52 citations

Interaction of the D₁Receptor Antagonist Sch 23390 with the Central 5-HT System: Radioligang Binding Studies, Measurements of Biochemical Parameters and Effects on L-5-HTP Syndrome

1988 • 46 citations

The Two-Syndrome Concept and Neuroendocrinology of Schizophrenia

1986 • 23 citations

新規なトランキライザー.クロザピン 臨床経験と臨床薬理学的仮説

1972 • 22 citations

Is it possible to model psychotic states in animals?

1987 • 22 citations