5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

1989 • 600 citations

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity

1988 • 548 citations

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

1987 • 526 citations

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1987 • 455 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

The concept of selectivity in 5-HT receptor research

1990 • 425 citations

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1986 • 354 citations

Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors

1976 • 350 citations

Effects of enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1986 • 312 citations

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1987 • 301 citations

Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release

1989 • 277 citations

Neuropharmacology of Serotonin

1989 • 268 citations

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

1989 • 266 citations

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

1988 • 255 citations

Regulation of monoamine metabolism in the central nervous system.

1972 • 241 citations

Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics

1986 • 225 citations

An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat

1977 • 210 citations

The dorsal and medial raphe projections to the substantia nigra in the rat: Electrophysiological, biochemical and behavioural observations

1978 • 208 citations

Serotonergic inhibition of catecholamine-induced behavioral arousal

1973 • 200 citations

Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release

1989 • 191 citations

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

1988 • 186 citations

Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate

1991 • 143 citations

8-hydroxy-2-(di-N-propylamino) tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis

1988 • 126 citations

Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by microdialysis

1990 • 114 citations

Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA

1990 • 114 citations

Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system

1976 • 111 citations

Differential effects of Para-chlorophenylalanine on amphetamine-induced locomotion and stereotypy

1976 • 97 citations

Modulation of striatal dopamine metabolism by the activity of dorsal raphe serotonergic afferences

1987 • 94 citations

Biochemical and behavioral effects of serotonin neurotoxins on the nigrostriatal dopamine system: Comparison of injection sites

1978 • 92 citations

Neurotoxicity of MDMA: Neurochemical Effects

1990 • 86 citations

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine

1990 • 86 citations

Putative selective 5-HT-2 antagonists block serotonin 5-HT-1c receptors in the choroid plexus.

1988 • 79 citations

5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.

1991 • 78 citations

5‐HT₂ Receptors, Roles and Regulation

1990 • 63 citations

Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats.

1990 • 61 citations

Effect of 3,4‐Methylenedioxymethamphetamine on 3,4‐Dihydroxyphenylalanine Accumulation in the Striatum and Nucleus Accumbens

1990 • 56 citations

5-HT2 receptor antagonists reverse amphetamine-induced slowing of dopaminergic neurons by interfering with stimulated dopamine synthesis.

1992 • 45 citations

Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys

1989 • 41 citations

Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5‐HT₂ receptors

1988 • 39 citations

Recreational Use of MDMA

1990 • 38 citations

Effects of (±)3,4-methylenedioxymethamphetamine (MDMA) on brain dopaminergic activity in rats

1989 • 37 citations

Non-serotonergic [3H]ketanserin binding sites in striatal membranes are associated with a dopac release system on dopaminergic nerve endings

1987 • 34 citations

(±)-3,4-Methylenedioxymethamphetamine-induced changes in the basal activity and pharmacological responsiveness of nigrostriatal dopamine neurons

1989 • 31 citations

Effects of severe dopamine depletion on dopamine neuronal impulse flow and on tyrosine hydroxylase regulation

1981 • 29 citations

Evidence that amphetamine and Na+ gradient reversal increase striatal synaptosomal dopamine synthesis through carrier-mediated efflux of dopamine

1986 • 23 citations

Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle

1990 • 21 citations

Involvement of serotonin in mediation of inhibition of substantia nigra neurons by noxious stimuli

1989 • 11 citations

Evidence for a functional coupling between dopamine reuptake and tyrosine hydroxylation in striatal nerve terminals

1982 • 7 citations

The neurobiology of schizophrenia

1991 • 5 citations