Seroquel: biochemical profile of a potential atypical antipsychotic

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Brain dopamine receptors.

1980 • 1,878 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1982 • 1,049 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

An Anatomy of Schizophrenia?

1973 • 721 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

[³H]8‐Hydroxy‐2‐(Di‐n‐Propylamino)Tetralin Binding to Pre‐ and Postsynaptic 5‐Hydroxytryptamine Sites in Various Regions of the Rat Brain

1985 • 458 citations

Binding characteristics of 3H-prazosin to rat brain α-adrenergic receptors

1979 • 419 citations

The Risks and Benefits of Clozapine versus Chlorpromazine

1987 • 299 citations

Clozapine: neuroleptic-induced EPS and tardive dyskinesia

1989 • 256 citations

Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol

1973 • 256 citations

Clozapine in treatment-resistant schizophrenics.

1988 • 215 citations

CLOZAPINE AND HALOPERIDOL IN A SINGLE‐BLIND CROSS‐OVER TRIAL: THERAPEUTIC AND BIOCHEMICAL ASPECTS IN THE TREATMENT OF SCHIZOPHRENIA

1974 • 198 citations

Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons

1985 • 196 citations

Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain

1986 • 177 citations

CLOZAPINE AND AGRANULOCYTOSIS

1975 • 175 citations

Sequence and significance of dopamine metabolism in the rat brain

1985 • 158 citations

Clozapine, Chlorpromazine, and Placebo in Newly Hospitalized, Acutely Schizophrenic Patients

1979 • 146 citations

Clozapine-induced agranulocytosis: non-cross-reactivity with other psychotropic drugs.

1988 • 123 citations

Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain

1989 • 122 citations

Seroquel: electrophysiological profile of a potential atypical antipsychotic

1993 • 117 citations

Neuroleptic-Induced Extrapyramidal Reactions

1983 • 109 citations

Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug

1993 • 103 citations

Clozapine--a potential antipsychotic agent without extrapyramidal manifestations.

1974 • 98 citations

Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex

1989 • 91 citations

5-HT2 receptor blockade by ICI 169,369 and other 5-HT2 antagonists modulates the effects of D-2 dopamine receptor blockade.

1990 • 88 citations

Rapid automated analysis of biogenic amines and their metabolites using reversed-phase high-performance liquid chromatography with electrochemical detection

1984 • 88 citations

CLOZAPINE AND AGRANULOCYTOSIS

1975 • 86 citations

D-1 and D-2 dopamine receptor blockade: interactive effects in vitro and in vivo.

1986 • 83 citations

Differential Effect of Subchronic Treatment with Various Neuroleptic Agents on Serotonin₂ Receptors in Rat Cerebral Cortex

1986 • 80 citations

Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain

1984 • 74 citations

Dopamine receptor occupancy in vivo: Measurement using N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ)

1989 • 48 citations

Alterations in dopamine metabolism after chronic administration of haloperidol

1985 • 44 citations

3-Methoxytyramine accumulation: Effects of typical neuroleptics and various atypical compounds

1986 • 30 citations

Repeated atypical neuroleptic administration: effects on central dopamine metabolism monitored by in vivo voltammetry

1987 • 28 citations

Clozapine and haloperidol in the amygdaloid complex: Differential effects on dopamine transmission with long-term treatment

1988 • 15 citations

On the mechanism of the different sensitivity of Purkinje and myocardial fibers to strophanthidin.

1990 • 14 citations

Characterization of [3H]Rauwolscine binding to alpha2-adrenoceptor sites in the lumbar spinal cord of the cat: Comparison to such binding sites in the cat frontal cerebral cortex

1986 • 13 citations

Clozapine--a potential antipsychotic agent without extrapyramidal manifestations.

1975 • 13 citations

Clozapine concentrations in brain regions: Relationship to dopamine metabolite increase

1978 • 10 citations

Prefrontal cortex: Possible site of antipsychotic action of haloperidol

1986 • 10 citations