Mode of Action of Anti-Inflammatory Agents Which are Prostaglandin Synthetase Inhibitors

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Personal communication

1989 • 2,984 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

1971 • 1,433 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Drugs which inhibit prostaglandin biosynthesis.

1974 • 1,325 citations

Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

1971 • 940 citations

Prostaglandins: Their Disappearance from and Release into the Circulation

1967 • 898 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

Advances in Prostaglandin and Thromboxane Research

1976 • 840 citations

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

1972 • 773 citations

THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES

1971 • 658 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

Arachidonate lipoxygenase in blood platelets

1975 • 613 citations

EFFECTS OF SALICYLATES ON HUMAN PLATELETS

1968 • 564 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

Interaction of anti-inflammatory drugs with serum proteins, especially with some biologically active proteins

1968 • 492 citations

A BRADYKININ‐POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARACA

1965 • 488 citations

Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation

1973 • 485 citations

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

1972 • 478 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM LEUKOCYTES EXPOSED TO IMMUNE COMPLEXES AND OTHER PARTICLES

1971 • 439 citations

New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs

1974 • 427 citations

Prostaglandin Synthetase Inhibitors

1977 • 394 citations

“The Role of Cyclic 3′, 5′ Adenosine Monophosphate in the Specific Cytolytic Activity of Lymphocytes”

1972 • 388 citations

Effect of Cyclic AMP on Release of Lysosomal Enzymes from Phagocytes

1971 • 380 citations

Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits

1971 • 358 citations

Salicylate Damage to the Gastric Mucosal Barrier

1967 • 347 citations

Glucocorticoid Inhibition of Glucose Uptake by Peripheral Tissues: Old and New Evidence, Molecular Mechanisms, and Physiological Significance

1971 • 347 citations

Cecil-Loeb Textbook of Medicine.

1971 • 345 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 339 citations

DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS

1960 • 337 citations

Cutaneous reactions to intradermal prostaglandins

1971 • 337 citations

Human Granulocyte Collagenase

1968 • 335 citations

Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation

1973 • 318 citations

Release of Noradrenaline from Sympathetic Endings

1971 • 316 citations

Ovulation blockade by aspirin or indomethacin - in vivo evidence for a role of prostaglandin in gonadotrophin secretion

1972 • 313 citations

The Role of Cyclic 3′,5′ Adenosine Monophosphate in the Specific Cytolytic Activity of Lymphocytes

1972 • 305 citations

Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

1973 • 296 citations

Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

1997 • 295 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

Prostaglandin Synthetase Inhibitors I

1979 • 279 citations

Inhibition of prostaglandin synthesis in man

1972 • 276 citations

INFLUENCE OF ACETYLSALICYLIC ACID, AN INHIBITOR OF PROSTAGLANDIN SYNTHESIS, ON THE DURATION OF HUMAN GESTATION AND LABOUR

1973 • 275 citations

Blockade of spontaneous and LH-induced ovulation in rats by indomethacin, an inhibitor of prostaglandin biosynthesis

1972 • 273 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

Corticosteroids inhibit prostaglandin production by rheumatoid synovia

1975 • 261 citations

Prostaglandins in Cellular Biology

1972 • 260 citations

Selective inhibition by mepacrine of the release of “rabbit aorta contracting substance” evoked by the administration of bradykinin

1972 • 249 citations

Cytochalasin B: Effect on Lysosomal Enzyme Release from Human Leukocytes

1973 • 243 citations

Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusion

1969 • 240 citations

Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids

1975 • 239 citations

BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS

1965 • 238 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 233 citations

Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lung

1974 • 226 citations

The National Research Centre for Disaster Prevention

1972 • 226 citations

Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea‐pig lungs

1973 • 223 citations

Lysosomal Mechanisms of Tissue Injury in Arthritis

1972 • 213 citations

Action of sodium salicylate and related compounds on tissue metabolism in vitro.

1956 • 212 citations

Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs

1972 • 207 citations

Recovery of Prostaglandins in Human Cutaneous Inflammation

1971 • 206 citations

Pyrogen fever and prostaglandin‐like activity in cerebrospinal fluid

1973 • 204 citations

PROSTAGLANDIN E₁: A POTENTIAL MEDIATOR OF THE INFLAMMATORY RESPONSE

1971 • 203 citations

Aspirin and Indomethacin Prolong Parturition in Rats: Evidence that Prostaglandins Contribute to Expulsion of Foetus

1972 • 198 citations

Human Collagenase: Identification and Characterization of an Enzyme from Rheumatoid Synovium in Culture

1967 • 197 citations

Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint

1975 • 196 citations

The effects of an inhibitor of prostaglandin synthesis (indomethacin) on ovulation, pregnancy, and pseudopregnancy in the rabbit

1972 • 192 citations

Prostaglandin on Cutaneous Vasculature**From the Department of Dermatology, College of Medicine, University of Illinois.

1968 • 191 citations

Biochemistry of the acute allergic reactions

1969 • 190 citations

Visceral pain and the pseudaffective response to intra-arterial injection of bradykinin and other algesic agents.

1962 • 189 citations

Inflammation mechanisms and control

1974 • 189 citations

The contribution of prostaglandin production to contractions of the isolated uterus of the rat

1973 • 186 citations

Textbook of immunopathology

1969 • 186 citations

Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells

1975 • 184 citations

Prostaglandins, oxygen tension and smooth muscle tone

1972 • 180 citations

Fever produced by prostaglandin E₁

1971 • 178 citations

Streptococci and Streptococcal Diseases. Recognition, Understanding, and Management.

1973 • 178 citations

Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition

1976 • 176 citations

Damage to proteins by peroxidized lipids

1963 • 174 citations

The Dissociation by Colchicine of Phagocytosis from Increased Oxygen Consumption in Human Leukocytes*

1967 • 173 citations

Non-Steroid Anti-Inflammatory Agents

1963 • 169 citations

Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine.

1973 • 168 citations

Pharmacologic Agents Released in Ultraviolet Inflammation Studied by Continuous Skin Perfusion

1970 • 167 citations

A histopathological and pharmacological analysis of the mode of action of non‐steroidal anti‐inflammatory drugs

1971 • 165 citations

Studies on prostaglandin antagonists

1971 • 157 citations

THE EFFECTS OF CORTICOSTEROIDS UPON CONNECTIVE TISSUE AND LYSOSOMES.

1964 • 154 citations

Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating

1973 • 154 citations

A CHEMOTACTIC ROLE FOR PROSTAGLANDINS RELEASED FROM POLYMORPHONUCLEAR LEUCOCYTES DURING PHAGOCYTOSIS

1975 • 154 citations

Biochemical properties of anti-inflammatory drugs—III.

1964 • 152 citations

Displacement of One Drug by Another from Carrier or Receptor Sites

1965 • 152 citations

Prostaglandin synthesis by bovine mesenteric arteries and veins.

1975 • 152 citations

EFFECT OF ANTI-INFLAMMATORY AGENTS ON PLATELETS

1968 • 148 citations

Prostaglandin E₂ and gastric acid secretion in man

1973 • 147 citations

Release of Prostaglandins in Ocular Inflammation in the Rabbit

1972 • 146 citations

Polymorphonulcear leukocyte chemotaxis toward oxidized lipid components of cell membranes.

1975 • 145 citations

Contribution of Intrarenal Generation of Prostaglandin to Autoregulation of Renal Blood Flow in the Dog

1973 • 142 citations

Connective tissue activation

1980 • 142 citations

The destruction of —SH groups of proteins and amino acids by peroxides of unsaturated fatty acids

1962 • 141 citations

Studies on the Mechanism of Swelling, Lysis, and Distintegration of Isolated Liver Mitochondria Exposed to Mixtures of Oxidized and Reduced Glutathione

1964 • 139 citations

The Immediate Allergic Response: in Vitro Action of Cyclic Amp-Active and Other Drugs on the Two Stages of Histamine Release

1971 • 138 citations

ANALGESIC ANTIPYRETIC DRUGS AS ANTAGONISTS OF BRADYKININ

1960 • 137 citations

Delay of Parturition in the Rat by Anti-Inflammatory Agents which Inhibit the Biosynthesis of Prostaglandins

1972 • 137 citations

Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro

1971 • 133 citations

Future Trends in Inflammation

1975 • 132 citations

Prostaglandins and lymphokines in arthritis

1974 • 132 citations

Prostaglandin-like Activity in Ocular Inflammation

1972 • 131 citations

Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen

1973 • 124 citations

Immunologic Release of Histamine and Slow Reacting Substance of Anaphylaxis from Human Lung

1973 • 124 citations

Comparison of Prostaglandin E1 and Norepinephrine on the Gastric Mucosal Circulation

1970 • 122 citations

Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin induced inflammation in the rat

1971 • 122 citations

Further studies on prostaglandin E₁ fever in cats

1971 • 119 citations

Relationship of induced histidine decarboxylase activity and histamine synthesis to shock from stress and from endotoxin

1960 • 119 citations

Book Review: Biochemistry of the Acute Allergic Reactions

1969 • 118 citations

Release of Vasoactive Substances from Guinea-Pig Lungs by Slow-Reacting Substance C and Arachidonic Acid

1971 • 117 citations

Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis.

1969 • 116 citations

Inflammation Biochemistry and Drug Interaction

1971 • 115 citations

EFFECT OF ASPIRIN ON HUMAN SEMINAL PROSTAGLANDINS

1971 • 113 citations

The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs

1972 • 113 citations

The Toxic Effects of Phenylbutazone (Butazolidin)

1955 • 110 citations

Chemistry of Thrombolysis: Human Fibrinolytic Enzymes.

1963 • 103 citations

Effect of Prostaglandin E1 on Leukocyte Migration

1971 • 103 citations

The role of copper in prostaglandin synthesis

1973 • 102 citations

Prostaglandins in Human Burn Blister Fluid

1973 • 99 citations

Salicylate and enzymes

1971 • 99 citations

Textbook of Immunopathology.

1969 • 98 citations

Inhibition of the conversion of angiotensin I to II and potentiation of bradykinin by small peptides present in Bothrops jararaca venom.

1972 • 96 citations

Cutaneous vascular reactions to prostaglandins in healthy subjects and in

1969 • 95 citations

Inhibition of bradykinin vasodilation and potentiation of norepinephrine and angiotensin vasoconstriction by inhibitors of prostaglandin synthesis in skeletal muscle of the rat.

1975 • 95 citations

NARCOTIC AND NON-NARCOTIC ANALGESICS WHICH BLOCK VISCERAL PAIN EVOKED BY INTRA-ARTERIAL INJECTION OF BRADYKININ AND OTHER ALGESIC AGENTS.

1964 • 93 citations

Effect of Prostaglandin E2 on Adjuvant Arthritis

1969 • 91 citations

Plate Tectonics and the Hercynian Orogeny

1972 • 91 citations

The influence of psychotropic drugs on prostaglandin biosynthesis

1974 • 90 citations

Identification of Prostaglandin F2α released by Distension of Guinea-pig Uterus in vitro

1971 • 90 citations

Suppression of enzyme release from isolated rat liver lysosomes by non-steroidal anti-inflammatory drugs

1968 • 89 citations

Lysosomal enzyme activity in rats with adjuvant-induced arthritis.

1970 • 85 citations

Immunochemical and biologic properties of rat IgE. II. Capacity to mediate the immunologic releas of histamine an slow-reacting substance of anaphylaxis (SRS-A).

1970 • 84 citations

Aspirin and indomethacin: Effect on instillation/abortion time of mid-trimester hypertonic saline induced abortion

1973 • 83 citations

Release of histamine, kinin and prostaglandins during carrageenin-induced inflammation in the rat.

1969 • 83 citations

The release of PGE2-like activity into aqueous humor after paracentesis and its prevention by aspirin.

1973 • 82 citations

Effect of Acetylsalicylic Acid on Lysosomes.

1966 • 81 citations

Inhibition of Prostaglandin Biosynthesis by Corticosteroids

1972 • 81 citations

Prostaglandins and the Aspirin-Like Drugs

1972 • 81 citations

The biochemical pathology of aspirin-induced gastric damage

1975 • 79 citations

Accumulation of Drug Anions in Gastric Mucosal Cells

1963 • 77 citations

Analgesic‐antipyretic drugs as antagonists of endotoxin shock in dogs

1962 • 77 citations

Influence of acetylsalicylic acid and salicylaide on the coagulation of blood.

1960 • 76 citations

PHARMACOLOGICAL ACTIONS OF BRADYKININ AND ITS ROLE IN PHYSIOLOGICAL AND PATHOLOGICAL REACTIONS

1963 • 76 citations

Serum Sulfhydryl Determinations and Significance in Connective Tissue Diseases

1964 • 76 citations

A pharmacological analysis of aspirin.

1969 • 74 citations

Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs

1972 • 74 citations

Endogenous Prostaglandins modulate Lipolytic Processes in Adipose Tissue

1971 • 73 citations

Effect of Prostaglandins E1 and F1α on Biosynthesis of Collagen

1972 • 73 citations

THE ROLE OF PROSTAGLANDINS IN RABBIT MONOARTICULAR ARTHRITIS

1974 • 71 citations

Effects of prostaglandins PGF_2α and PGE₁ on vascular permeability

1968 • 69 citations

Some Biochemical and Pharmacological Properties of Anti-Inflammatory Drugs

1965 • 69 citations

THE EFFECT OF PROSTAGLANDIN E₁ ON RESPONSES OF SMOOTH MUSCLE TO CATECHOL AMINES, ANGIOTENSIN AND VASOPRESSIN

1963 • 69 citations

The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins

1972 • 66 citations

Inhibition of Histamine Release in Experimental Diabetes

1957 • 65 citations

A Pharmacological Analysis of Aspirin

1970 • 65 citations

BRADYKININ AND OEDEMA FORMATION IN HEATED PAWS OF RATS

1967 • 65 citations

Aspirin: Intestinal Damage in Rats

1970 • 63 citations

Influence of diabetes upon the inflammatory response of the rat. A pharmacological analysis

1973 • 63 citations

Immunochemical and biologic properties of rat IgE. 3. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3',5'-adenosine monoposphate.

1970 • 63 citations

ON THE ABILITY OF PROSTAGLANDIN E₁ AND ARACHIDONIC ACID TO MODULATE EXPERIMENTALLY INDUCED OEDEMA IN THE RAT PAW

1975 • 63 citations

Studies on the Mode of Action of Non-Steroidal Anti-Inflammatory Agents

1972 • 62 citations

Anti-inflammatory drugs and renal papillary necrosis

1975 • 61 citations

Lysosomal enzymes and inflammation with particular reference to rheumatoid diseases.

1971 • 61 citations

Effects of lysosomal collagenolytic enzymes, anti-inflammatory drugs and other substances on some properties of insoluble collagen

1969 • 58 citations

Prostaglandin e₁ (pge₁) suppression of adjuvant arthritis histopathology

1973 • 57 citations

Prostaglandin synthetase inhibitors and leucocytic emigration

1975 • 56 citations

Studies on plasma kallikrein and its relationship to plasmin.

1960 • 56 citations

Biochemical properties of anti-inflammatory drugs—VIII

1966 • 55 citations

Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.

1970 • 54 citations

In vivo observations of the effects of cortisone upon the blood vessels in rabbits ear chambers.

1952 • 54 citations

A Unified Theory of Glucocorticoid Action

1964 • 52 citations

Inhibition of prostaglandin synthetase by aspirin-like drugs in different microsomal preparations.

1976 • 51 citations

Enzyme Release from Guinea-pig Polymorphonuclear Leucocyte Lysosomes Inhibited in vitro by Anti-Inflammatory Drugs

1972 • 50 citations

The effects of adrenalectomy and corticosterone on vascular permeability responses in the skin of the rat.

1975 • 49 citations

COLLAGENOLYTIC ACTIVITY OF THE SKIN ASSOCIATED WITH NEUROMUSCULAR DISEASES INCLUDING AMYOTROPHIC LATERAL SCLEROSIS

1966 • 49 citations

Inhibition of abortion and fetal death produced by endotoxin or prostaglandin F2α

1972 • 49 citations

Leukocytes and prostaglandins in acute inflammation

1974 • 47 citations

Essential fatty acid deficiency: A condition to discriminate prostaglandin and non-prostaglandin mediated components of inflammation

1976 • 46 citations

The effects of acetaminophen and sodium salicylate on the release and activity of leukocytic pyrogen in the cat.

1972 • 46 citations

Prostaglandins and the anti-inflammatory activities of aspirin and sodium salicylate

1975 • 46 citations

HEMORRHAGIC DIATHESIS WITH INCREASED CAPILLARY FRAGILITY CAUSED BY SALICYLATE THERAPY

1956 • 45 citations

Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis

1972 • 45 citations

EFFECTS OF ASPIRIN ON PROSTAGLANDIN AND FRUCTOSE LEVELS IN HUMAN SEMEN

1973 • 45 citations

Effect of drugs on urate binding to plasma proteins

1969 • 43 citations

Antiarthritic and Antiinflammatory Effects of Certain Prostaglandins

1972 • 42 citations

Studies of the cortisone effects on the inflammatory response. 1. Alterations of the histopathology of chemically induced inflammation.

1952 • 42 citations

How aspirin might work: A pharmacokinetic approach

1974 • 42 citations

Effect of Non-narcotic Analgesics on Membrane Permeability of Molluscan Neurones

1972 • 41 citations

The Action of Some Analgesic Drugs in Intact and Chronic Spinal Rats.

1953 • 41 citations

A central component in the analgesic action of sodium salicylate.

1971 • 40 citations

Appearance of prostaglandins in the renal venous blood of dogs in response to acute systemic hypotension produced by bleeding or endotoxin.

1973 • 40 citations

How aspirin might work: A pharmacokinetic approach

1994 • 39 citations

Prostaglandins as regulators of bradykinin responses

1973 • 39 citations

The ability of nonsteroid anti-inflammatory compounds to accelerate a disulfide interchange reaction of serum sulfhydryl groups and 5,5′-dithiobis(2-nitrobenzoic acid)

1967 • 39 citations

The inflammatory response to carrageenan

1975 • 38 citations

Prostaglandins and the anti-inflammatory activity of a human plasma fraction in carrageenan-induced paw oedema in the rat

1974 • 38 citations

Pharmacologic Dissociation of Immunologic Release of Histamine and Slow Reacting Substance of Anaphylaxis in Rats

1968 • 38 citations

Studies on Mechanism of Action of Salicylates V: Effect of Salicylic Acid on Enzymes Involved in Mucopolysaccharides Synthesis

1969 • 37 citations

Aspirin and Prostaglandins

1974 • 37 citations

Proceedings: Prostaglandin production by rabbit peritoneal polymorphonuclear leukocytes in vitro.

1972 • 37 citations

The role of polymorphonuclear leucocytes in acute inflammation in agranulocytic rats

1969 • 36 citations

Novel transformations of prostaglandin endoperoxides: formation of thromboxanes.

1976 • 36 citations

Immunochemical and Biologic Properties of Rat IgE

1970 • 36 citations

Proceedings: the concomitant release of bradykinin and prostaglandin in the inflammatory response to carrageenin.

1974 • 36 citations

Chemistry of Thrombolysis: Human fibrinolytic Enzymes.

1964 • 35 citations

Effects of a human plasma fraction on leucocyte migration into inflammatory exudates

1975 • 35 citations

METHODS FOR THE DIRECT MEASUREMENT OF ANTI-INFLAMMATORY ACTION ON HUMAN TISSUE MAINTAINED IN VITRO

1970 • 35 citations

INHIBITION BY NON‐STEROID ANTI‐INFLAMMATORY AGENTS OF RABBIT AORTA CONTRACTING ACTIVITY GENERATED IN BLOOD BY SLOW REACTING SUBSTANCE C

1974 • 34 citations

Aspirin and Algesimetry

1959 • 34 citations

Plasma inflammation units: An objective method for investigating effects of drugs on experimental inflammation

1966 • 34 citations

Proceedings: Prostaglandin generation maintains the smooth muscle tone of the rabbit isolated jejunum.

1972 • 32 citations

Prostaglandin synthetase systems of rabbit tissues and their inhibition by nonsteroidal anti-inflammatory drugs.

1976 • 32 citations

ANALGESIC‐ANTIPYRETIC DRUGS AS INHIBITORS OF KALLIKREIN

1961 • 32 citations

Aspirin Stabilization of the Blood-Aqueous Barrier in the Human Eye

1975 • 32 citations

Influence of Cortisone upon Acute Inflammation.

1952 • 32 citations

Inhibition of functional vasodilatation and prostaglandin formation in rabbit adipose tissue by indomethacin and aspirin

1973 • 32 citations

Evidence for altered lysosomal membranes in synovial lining cells from human rheumatoid joints.

1971 • 31 citations

Effect of cyclic 3',5'-monophosphate on edema and granuloma induced by carrageenin

1972 • 31 citations

CECIL-LOEB TEXTBOOK OF MEDICINE

1968 • 30 citations

SIMPLE SCREENING TEST FOR ANTIRHEUMATIC DRUGS

1965 • 30 citations

Are platelets important in inflammation?

1975 • 30 citations

Future trends in inflammation II.

1975 • 30 citations

Vasoconstriction in the Cheek Pouch of the Hamster Following Treatment With Cortisone

1954 • 29 citations

More Coals of Fire for Club of Rome

1972 • 29 citations

Prostaglandins and aspirin: An alternative view

1975 • 28 citations

Nonsteroid Anti-Inflammatory Agents

1966 • 28 citations

Comparative activities, tolerances and safety of nonsteroidal anti-inflammatory agents in rats.

1975 • 28 citations

Blood platelets and the inflammatory process

1974 • 27 citations

THE INFLAMMATORY MEDIATORS *

1974 • 27 citations

Influence of prostaglandins E, A and F on vasoconstrictor responses to norepinephrine, renal nerve stimulation and angiotensin in the feline kidney.

1976 • 27 citations

Release of prostaglandins and incapacitation after injection of endotoxin in the knee joint of the dog.

1975 • 26 citations

The requirement for platelets in the active Arthus reaction.

1971 • 26 citations

Smooth Muscle Stimulating Lipids in Peripheral Lymph after Experimental burn injury

1971 • 26 citations

Arachidonic acid, an unsaturated fatty acid which produces slow contractions of smooth muscle and causes pain. Pharmacological and biochemical characterisation of its mode of action.

1959 • 26 citations

Pro-Inflammatory Effects of Certain Prostaglandins

1972 • 26 citations

Interaction of Lysosomes and Anti-inflammatory Drugs

1969 • 26 citations

STUDIES ON KALLIKREIN: FAILURE OF SOME ANTI‐INFLAMMATORY DRUGS TO AFFECT RELEASE OF KININ

1966 • 25 citations

Proceedings of the Sixth International Congress of Pharmacology

1976 • 25 citations

Interactions between bradykinin and prostaglandins

1975 • 25 citations

Vergleichende Untersuchungen �ber die Wirkung von Pyrazolen und Antihistaminen bei verschiedenen Arten der experimentellen Entz�ndung

1950 • 25 citations

An acute inflammation induced by inorganic pyrophosphate and adenosine triphosphate, and its inhibition by cyclic 3′,5′-adenosine monophosphate

1972 • 25 citations

PROCEEDINGS OF THE British Pharmacological Society

1974 • 25 citations

INHIBITION OF PROTEIN DENATURATION BY ANTIRHEUMATIC OR ANTIPHLOGISTIC AGENTS.

1964 • 24 citations

COMPETITIVE AND NON‐COMPETITIVE INHIBITION OF BRADYKININ ON THE GUINEA‐PIG ILEUM

1965 • 24 citations

Inhibition of uterine motility: the possible role of the prostaglandins and aspirin-like drugs

1975 • 24 citations

Connective tissue activation. IV. Regulatory effects of antirheumatic drugs

1972 • 24 citations

INHIBITION OF THE PHENOMENON OF LOCAL TISSUE REACTIVITY BY CORTICOSTEROIDS, SALICYLATES, AND COMPOUNDS RELATED TO SALICYLATES

1953 • 24 citations

Advanced Medicine. Topics in Therapeutics. 1

1976 • 23 citations

Collagen metabolism in adjuvant-induced arthritis in the rat.

1972 • 23 citations

The effect of indomethacin on the tracheal smooth muscle of the guinea-pig.

1972 • 22 citations

Physiological Pharmacology. A Comprehensive Treatise

1964 • 22 citations

The Inhibitory Effects of some Antiphlogistic Drugs on the Glucosamine Incorporation into Mucopolysaccharides Synthesized by Fibroblast Cultures

1967 • 22 citations

PROSTAGLANDIN E COMPOUNDS AND SYMPATHETIC NEUROMUSCULAR TRANSMISSION

1971 • 21 citations

Reduction of the inflammatory response in rats immunized against prostaglandins

1974 • 20 citations

Effect of Cortisone upon Local Capillary Permeability

1954 • 20 citations

Search for Common Mechanisms Underlying the Various Effects of Putative Inflammatory Mediators

1974 • 19 citations

Changes in cellular enzyme levels and the inhibition of selective release of lysosomal hydrolases from macrophages by indomethacin

1975 • 19 citations

Proceedings: Effects of prostaglandin E2 on rat gastric mucosal blood flow, as determined by 14C-aniline clearance.

1972 • 19 citations

Effects on Anaphylactic Shock of Salicylates, Aminopyrine and Other Chemically and Pharmacologically Related Compounds.

1950 • 19 citations

PROTEOLYTIC ENZYMES AS MEDIATORS OF PAIN

1968 • 18 citations

The fibrinolytic activity of N-arylanthranilates

1966 • 18 citations

Delaney Amendment Once More in Question

1972 • 17 citations

Observations on the treatment of rheumatic fever with salicylate, ACTH and cortisone. II. Combined salicylate and corticoid therapy and attempts at rebound suppression

1958 • 17 citations

C-REACTIVE PROTEIN IN RHEUMATIC FEVER

1952 • 17 citations

Effects of Anti-inflammatory Drugs in Shock Caused by Injection of Living E. coli Cells

1971 • 17 citations

Studies on lysosome stabilization by antirheumatic drugs

1970 • 17 citations

Proceedings of the Sixth International Congress of Pharmacology

1976 • 17 citations

Anti-Prostaglandin Action of Colchicine

1975 • 17 citations

Versuche zur Isolierung des Kallikrein-Inaktivators, IV. Kristallisation und Aminosäurezusammensetzung, Vergleich mit dem Trypsin-Inhibitor von Kunitz und Northrop

1963 • 16 citations

Salicylate Effects on Gastric Acid Secretion

1974 • 16 citations

In vitro inhibition of the biosynthesis of a prostaglandin by gold and silver

1973 • 16 citations

Introduction and Background to the Regulation of Inflammation and the Immune Response

1974 • 14 citations

EFFECTS OF THE NON-STEROIDAL ANTIPHLOGISTICS ON THE GASTRIC MUCOSAL BARRIER AND HEXOSAMINE CONTENT IN RATS

1972 • 14 citations

Presence of a slow-contraction inducing material in fluid collected from the rat paw oedema induced by serotonin

1965 • 14 citations

Aspirin and mucus

1968 • 14 citations

Effects of Angiotensin II on the Permeability of the Vascular Wall

1974 • 14 citations

Effect of two non-steroidal anti-inflammatory agents on alkaline and acid phosphatases of inflamed tissue

1968 • 13 citations

The fibrinolytic activity of anti-inflammatory drugs

1966 • 13 citations

Inhibition of Experimental Arteritis by Cortisone, Salicylate and Related Compounds

1952 • 13 citations

Interaction between plasma proteins and antirheumatic or new antiphlogistic drugs.

1965 • 13 citations

Antagonism of anti-inflammatory drugs on bradykinin-induced increase of capillary permeability

1967 • 11 citations

The selective inhibition of microbial RNA synthesis by salicylate

1972 • 11 citations

Measurement of gastrointestinal blood loss in the rat: the effect of aspirn, phenylbutazone and seclazone.

1973 • 11 citations

Slowed lysosomal enzyme release and its normalization by drugs in adjuvant-induced polyarthritis

1971 • 11 citations

Correlation between in vitro and in vivo models in anti-inflammatory drug studies

1971 • 11 citations

The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammation

1974 • 11 citations

Evaluation for Immunosuppressive and Antiallergic Activity

1974 • 11 citations

Protein-bound peptides in human serum.

1971 • 10 citations

Antiinflammatory Compounds Exhibiting Fibrinolytic Activity

1966 • 10 citations

The action of salicylates on the development of antibodies following anti‐typhoid inoculation

1941 • 10 citations

Prevention of antiinflammatory drug-induced gastric lesions in rats by Abbott-29590

1974 • 8 citations

Actions and interactions of bradykinin, prostaglandins, and nonsteroidal antiinflammatory agents on the eye

1976 • 8 citations

Prostaglandins and the Microvascular System: Physiological and Histochemical Correlations

1972 • 8 citations

Effect of Anti-inflammatory Drugs on Glucosamine-6-phosphate Synthetase from Inflamed Tissue of Rats

1971 • 7 citations

Über die hemmung des wachstums vonLactobacillus casei durch einige antiphlogistica

1968 • 7 citations

Non-steroidal anti-inflammatory drugs

2006 • 6 citations

The role of prostaglandin in endotoxin-induced abortion and fetal death.

1973 • 6 citations

The effect of sodium salicylate on the ATP-level in normal and inflamed tissue

1967 • 6 citations

Activation of Fibrinolysis by Derivatives of Diphenyldioxopyrazolidine

1966 • 4 citations

In vivo measurement of the adhesiveness of granulocytes to blood vessel walls.

1973 • 4 citations

The effect of calcium acetylsalicylate on the content and distribution of mucus in the rat stomach.

1970 • 3 citations

Eine kritische Bemerkung zur Vergleichbarkeit der Wirkung entzündungshemmender Pharmaka auf die Glucosamin-6-phosphat-Synthese in vitro und am Rattenpfotenödem in vivo

1967 • 3 citations

[Histochemical study of experimental gastric lesions induced by acetylsalicylic acid and other drugs in rats].

1966 • 3 citations

Indomethacin in experimental nephritis: studies in Heymann-type nephritis and puromycin aminonucleoside nephropathy

1975 • 2 citations

Die Wirkung von entzündungshemmenden Pharmaka auf die Glucosamin-6-phosphat-Synthese in Rattenleberhomogenaten

1966 • 1 citations

EVIDENCE FOR IN VIVO AND IN VITRO INHIBITION OF PROSTAGLANDIN (PG) SYNTHESIS IN HUMAN SYNOVIAI MEMBRANE BY ASPIRIN-LIKE DRUG

1977 • 1 citations