Biochemical properties of anti-inflammatory drugs—III.

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

PHOTOMETRIC NINHYDRIN METHOD FOR USE IN THE CHROMATOGRAPHY OF AMINO ACIDS

1948 • 2,986 citations

A method for the fluorometric assay of histamine in tissues.

1959 • 2,390 citations

Identification and assay of serotonin in brain.

1956 • 850 citations

Aromatic l-Amino Acid Decarboxylase

1962 • 841 citations

REVERSIBLE INHIBITION OF THE COUPLING BETWEEN PHOSPHORYLATION AND OXIDATION

1948 • 656 citations

CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT

1963 • 523 citations

A New Method for the Detection of Peptides and Similar Compounds on Paper Chromatograms

1952 • 514 citations

GASOMETRIC DETERMINATION OF CARBOXYL GROUPS IN FREE AMINO ACIDS

1941 • 457 citations

ON THE PREPARATION AND PROPERTIES OF 2,4,6-TRINITROPHENYL-AMINO ACIDS AND -PEPTIDES*

1960 • 414 citations

Uncoupling of Oxidative Phosphorylation by Carbonyl Cyanide Phenylhydrazones. I. Some Characteristics of m-CI-CCP Action on Mitochondria and Chloroplasts

1963 • 338 citations

The reaction of p-nitrophenyl esters with chymotrypsin and insulin

1954 • 299 citations

5-HYDROXYTRYPTAMINE AND HISTAMINE AS MEDIATORS OF THE VASCULAR INJURY PRODUCED BY AGENTS WHICH DAMAGE MAST CELLS IN RATS

1956 • 297 citations

Sulfonyl Fluorides as Inhibitors of Esterases. II. Formation and Reactions of Phenylmethanesulfonyl α-Chymotrypsin^*

1964 • 294 citations

Mobilization and formation of histamine in the gastric mucosa as related to acid secretion

1964 • 284 citations

SPECIES DIFFERENCES IN ADRENOCORTICAL SECRETION

1953 • 271 citations

THE ANTI-INFLAMMATORY ACTIVITY OF GLYCYRRHETINIC ACID AND DERIVATIVES

1958 • 214 citations

Action of sodium salicylate and related compounds on tissue metabolism in vitro.

1956 • 212 citations

The Interaction of Uncoupling Phenols with Mitochondria and with Mitochondrial Protein

1965 • 209 citations

The Specific Binding of Pyridoxal 5'-Phosphate to Bovine Plasma Albumin

1962 • 201 citations

PROTEOLYTIC ENZYMES OF MAST CELLS*

1963 • 197 citations

Evidence that induced histamine is an intrinsic regulator of the microcirculatory system

1962 • 188 citations

Inhibition of the anaphylactic reaction

1957 • 183 citations

5-HYDROXYTRYPTAMINE DEFICIENCY IN PHENYLKETONURIA

1957 • 157 citations

Hormonal Effects on Connective Tissue

1958 • 148 citations

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG

1961 • 146 citations

Preparation and Properties of 2,4-Dinitrophenyl-L-amino Acids

1954 • 141 citations

The Biosynthesis of Trimethylamine-N-Oxide

1962 • 138 citations

The inhibition of chymotrypsin by diethyl p-nitrophenyl phosphate

1952 • 136 citations

5‐Hydroxytryptamine and the anaphylactoid reaction in the rat

1957 • 128 citations

Inhibition of 5-Hydroxytryptophan Decarboxylase by Phenylalanine Metabolites

1958 • 128 citations

Über den wirkungsmechanismus des dicumarols und verwandter verbindungen

1953 • 126 citations

A Possible Basis for the Anti-inflammatory Activity of Salicylates and other Non-Hormonal Anti-Rheumatic Drugs

1958 • 126 citations

Distribution and properties of amino acid decarboxylases in gastric mucosa

1966 • 120 citations

The inhibition of oxidative phosphorylation

1951 • 119 citations

Interaction of Aromatic Compounds With α-Chymotrypsin^*

1963 • 110 citations

THE PHARMACOLOGY OF PHENYLBUTAZONE ANALOGUES

1960 • 105 citations

Advanced organic chemistry

1949 • 103 citations

Lipid solubility as a factor influencing the activity of uncoupling phenols

1962 • 100 citations

Biochemical properties of anti-inflammatory drugs—II

1964 • 99 citations

The enzymic oxidation of tryptophan to 5-hydroxytryptophan in the biosynthesis of serotonin.

1961 • 98 citations

Studies on 5-hydroxytryptophan decarboxylase. I. In vitro inhibition and substrate interaction

1959 • 97 citations

Studies on the action of some anti-inflammatory agents in inhibiting the biosynthesis of mucopolysaccharide sulphates

1961 • 96 citations

Histidine decarboxylase in the fetal rat

1963 • 95 citations

The formation of histamine by fetal rat liver

1962 • 92 citations

The formation of histamine in the rat foetus

1960 • 92 citations

WOUND HEALING

1960 • 90 citations

Ability of Some Antirheumatic Drugs to uncouple Oxidative Phosphorylation

1962 • 89 citations

The effect of some anti-inflammatory (anti-rheumatic) drugs on the metabolism of connective tissues

1962 • 82 citations

The effect of a new decarboxylase inhibitor on endogenous and exogenous monoamines

1963 • 81 citations

EFFECTS OF COMPOUND 48/80, CHYMOTRYPSIN AND ANTISERUM ON ISOLATED MAST CELLS UNDER AEROBIC AND ANAEROBIC CONDITIONS

1964 • 81 citations

New Approaches to the Physiology of Histamine

1962 • 78 citations

Anti-inflammatory, antipyretic and antinociceptive properties of N-(2,3-xylyl)anthranilic acid (mefenamic acid).

1962 • 75 citations

RENAL FUNCTION IN PATIENTS WITH GOUT 1

1940 • 75 citations

ISATOIC ANHYDRIDE. I. REACTIONS WITH PRIMARY AND SECONDARY AMINES AND WITH SOME AMIDES¹

1944 • 73 citations

Effect of Cortisone and Related Compounds on the Biogenesis of Cartilage

1961 • 73 citations

The Antirheumatic Effect of Sodium Gentisate

1948 • 72 citations

On the Active Site of Myosin A-Adenosine Triphosphatase

1960 • 72 citations

LONG-ACTING SULPHONAMIDES AND PROTEIN-BINDING

1960 • 72 citations

Studies on Coördination Compounds. II. The Dissociation Constants of β-Diketones in Water—Dioxane Solutions¹

1953 • 70 citations

Über die Reinigung und Spezifität der DOPA-Decarboxylase

1959 • 68 citations

Uncoupling of Oxidative Phosphorylation by some Arylacetic Acids (Anti-inflammatory or Hypocholesterolemic Drugs)

1964 • 67 citations

Anti‐inflammatory and antipyretic properties of N‐(α,α,α‐Trifluoro‐m‐tolyl) anthranilic acid (CI‐440; flufenamic acid)

1963 • 65 citations

AMODIAQUINE AND HYDROXYCHLOROQUINE IN RHEUMATOID ARTHRITIS

1959 • 62 citations

BIOCHEMICAL PHARMACOLOGICAL CONSIDERATIONS OF PHENYLBUTAZONE AND ITS ANALOGUES

1960 • 60 citations

Sodium -Resorcylate in Rheumatic Fever

1951 • 59 citations

Über einen neuen, gegen Vogelmalaria wirksamen Verbindungstypus

1948 • 59 citations

Inhibition of histidine decarboxylases

1963 • 58 citations

The transfer of [3H]stearic acid from chylomicra to milk fat in the goat

1964 • 58 citations

Clinical pharmacology of the new penicillins: II. Effect of drugs which interfere with binding to serum proteins

1966 • 57 citations

Acidität und Enolisierungstendenz

1944 • 57 citations

On the Mechanism of Oxidative Phosphorylation. VI. Localization of the Dithiol in Oxidative Phosphorylation with Respect to the Oligomycin Inhibition Site^*

1963 • 57 citations

The Amino Acid Sequence Around the “Reactive” Sulfhydryl Groups in Adenosine Triphosphocreatine Phosphotransferase^*

1965 • 57 citations

A study of structure-activity relationships in regard to species difference in the phenylbutazone series

1964 • 56 citations

Biochemical properties of anti-inflammatory drugs—VIII

1966 • 55 citations

Triggering action of phosphatidase A and chymotrypsins on degranulation of rat mesentery mast cells

1963 • 53 citations

A General Synthesis of the Troponoid System Based on Solvolysis of 1,4-Dihydrobenzyl Tosylates

1963 • 50 citations

The Formation of Histamine in the Rat

1961 • 49 citations

Insecticidal Properties of 1,3-Indandiones

1942 • 47 citations

The Analgesic and Antipyretic Properties of Some Derivatives of Salicylamide

1952 • 47 citations

5-Methylpyrazole-3-carboxylic Acid. The Potent Hypoglycemic Metabolite of 3,5-Dimethylpyrazole in the Rat

1965 • 47 citations

Specificity of α-Chymotrypsin

1961 • 46 citations

The suppression by anti‐esterases of increased capillary permeability in acute inflammation

1960 • 46 citations

Purification and properties of adrenal L-DOPA decarboxylase.

1959 • 46 citations

IDENTIFICATION BY DISTRIBUTION STUDIES. IX. APPLICATION TO METABOLIC STUDIES OF 4-AMINOQUINOLINE ANTIMALARIALS¹

1948 • 44 citations

Some effects of salicylate on mitochondria from rat liver

1959 • 44 citations

The Biochemistry of Mucopolysaccharides of Connective Tissue.

1961 • 44 citations

The effects of salicylic acid on the respiratory activity of mitochondria

1958 • 42 citations

HISTAMINE AND AUTONOMOUS RESPONSES OF THE MICROCIRCULATION; RELATIONSHIP TO GLUCOCORTICOID ACTION

1964 • 42 citations

Studies on 5-hydroxytryptophan decarboxylase. II. Additional inhibition studies and suggestions on the nature of the enzymic site

1960 • 42 citations

ANTI-INFLAMMATORY AND ANTIPYRETIC PROPERTIES OF N-(2,6-DICHLORO-M-TOLYL)ANTHRANILIC ACID (CI-583).

1965 • 40 citations

Inhibition of glucosamine‐6‐PO₄ synthesis by salicylate and other anti‐inflammatory agents in vitro

1961 • 40 citations

Studies on the biochemistry of heart valves I. On the biosynthesis of mucopolysaccharides in bovine heart valves

1963 • 39 citations

FURTHER STUDIES ON THE ROLE OF PROTEASES IN THE ALLERGIC REACTION

1961 • 39 citations

A New Preparation of Ninhydrin

1933 • 39 citations

Stereospecific Lossen Rearrangements

1959 • 38 citations

EFFECTIVENESS OF SALICYLAMIDE AS AN ANALGESIC AND ANTIRHEUMATIC AGENT

1955 • 37 citations

CXLII.—Triketohydrindene hydrate. Part IV. Hydrindantin and its analogues

1911 • 37 citations

Biochemical properties of anti-inflammatory drugs—IV

1965 • 37 citations

The mode of action of the antibiotic, usnic acid.

1950 • 37 citations

Effect of non-steroid anti-inflammatory drugs on aldehyde binding to plasma albumen: a novel in vitro assay for potential anti-inflammatory activity

1965 • 36 citations

Selective labeling and release of nonmast-cell histamine

1966 • 35 citations

Analgesic-Antipyretics

1960 • 35 citations

2-Substituted 1,3-Indandiones

1960 • 34 citations

Inhibition of dihydrocozymase-oxidase activity of heart-muscle preparations of certain cell-free bacterial preparations by 2-heptyl-4-hydroxyquinoline N-oxide

1958 • 33 citations

Ibufenac in the Treatment of Arthritis

1964 • 33 citations

STUDIES ON ESTER SULPHATES

1961 • 31 citations

A Biochemical Distinction Between Non-Steroid Anti-inflammatory and Analgesic Drugs

1963 • 31 citations

The effect of salicylate on adenosine-triphosphatase activity of rat-liver mitochondria

1962 • 30 citations

SIMPLE SCREENING TEST FOR ANTIRHEUMATIC DRUGS

1965 • 30 citations

Relations entre la structure moléculaire et le pouvoir inhibiteur des nitro- et halophénols

1955 • 29 citations

ON THE COAGULATION OF FIBRINOGEN

1943 • 29 citations

PHENOLIC COMPOUNDS IN CHEMOTHERAPY OF RHEUMATIC FEVER

1958 • 29 citations

Uncoupling of oxidative phosphorylation in rat liver mitochondria with desaspidin and related phlorobutyrophenone derivatives

1962 • 29 citations

The Complex Formation between Iron(III)Ion and Some Phenols. IV. The Acidity Constant of the Phenolic Group.

1955 • 29 citations

Pharmakotherapeutische Weiterentwicklung der Antipyretica-Antalgetica

1955 • 28 citations

O-methylation in vitro of dihydroxy- and trihydroxy-phenolic compounds by liver slices

1962 • 28 citations

An evaluation of the effect of salicylate on oxidative phosphorylation in rat liver mitochondria

1962 • 27 citations

Glycyrrhetinic Acid—A Triterpene with Anti-Oestrogenic and Anti-Inflammatory Activity

1960 • 27 citations

EFFECTS OF SALICYLATE ON GLUTAMATE DEHYDROGENASE AND GLUTAMATE DECARBOXYLASE

1963 • 27 citations

Wirkung von Phloridzin auf Mitochondrien

1958 • 27 citations

A new reagent for nitroguanidination of proteins

1964 • 25 citations

Concerning the regulation of some diverse biochemical reactions underlying the inflammatory response by salicylic acid, phenylbutazone and other acidic antirheumatic drugs

1966 • 25 citations

Chemobiodynamics and drug design

1960 • 25 citations

Anti-Inflammatory Compounds; P<scp>art</scp> I. T<scp>he</scp> A<scp>ctivity of a</scp> S<scp>eries of</scp> N<scp>ew</scp> C<scp>ompounds</scp> C<scp>ompared with</scp> P<scp>henylbutazone and</scp> C<scp>ortisone</scp>

1955 • 24 citations

A Method for Testing Analgesics in Rheumatoid Arthritis using a Sequential Procedure

1959 • 24 citations

Salicylate and aminotransferases

1965 • 24 citations

Role of anions in mitochondrial swelling and contraction

1965 • 24 citations

Reduction of salicylate to saligenin by Neurospora

1960 • 23 citations

Histamine formation in human wound tissue

1963 • 23 citations

The effect of hydrocortisone and cortisone on fixation of S35 in the stomach.

1958 • 22 citations

The Effect of Salicylic Acid, Benzoic Acid, and some of their Derivatives on Oxidative Phosphorylation.

1957 • 21 citations

Uric Acid Elimination in Man¹

1935 • 21 citations

Substituted Dihydroxybenzoic Acids as Possible Anti-Inflammatory Agents

1963 • 21 citations

Biochemical properties of anti-inflammatory drugs—V

1965 • 21 citations

Uncoupling of oxidative phosphorylation by some salicylamide derivatives

1966 • 20 citations

Inhibition of rat brain glutamate decarboxylase activity by salicylate in vitro

1965 • 19 citations

SYNTHESIS, POTENTIOMETRIC TITRATIONS, AND SPECTRA OF PYRAZOLONES

1953 • 18 citations

Protein-fluoroacid interaction. Bovines serum albuminperfluoro-octanoic acid

1954 • 18 citations

Über Derivate des Phenylbutazons. II. Derivate mit einer Hydroxylgruppe in der 4‐ständigen Seitenkette

1957 • 18 citations

An Improved Analytical Procedure for Automatic Analysis of Amino Acids

1966 • 18 citations

The Salol Reaction

1947 • 17 citations

3-Chloro-9-(4-diethylamino-1-methylbutylamino)acridine 10-Oxide and other 9-Aminoacridine N-Oxides

1962 • 16 citations

The Mechanism of the Anti-Inflammatory Activity of Salicylate

1961 • 15 citations

Über Aminothiosäuren II. Mitteil.: S‐Analoge einiger α‐Aminosäuren

1954 • 15 citations

The binding by bovine plasma and plasma fractions of salicylic acid and some of its 3-alkyl analogues

1962 • 15 citations

ON THE ESTEROLYTIC ACTIVITIES OF PAPAIN AND TRYPSIN

1957 • 15 citations

Über die stereoisomeren Hexahydro‐anthranilsäuren

1953 • 15 citations

[Effect of phenylbutazone on enzyme reactions and fermental-chemical transmission in cell metabolism].

1956 • 15 citations

The changes of gastric histidine decarboxylase activity during fasting and feeding

1965 • 15 citations

The assay of aromatic amino acid decarboxylase using radioactive substrates

1964 • 14 citations

Studies on the mechanism of action of salicylate: effects on orthophosphate-exchange reactions associated with oxidative phosphorylation

1963 • 14 citations

Biochemical and pharmacological properties of some amidopyrine metabolites

1964 • 14 citations

LABORATORY AND CLINICAL EXPERIENCE WITH SODIUM GENTISATE IN RHEUMATIC DISEASE

1952 • 12 citations

The antibacterial activity of usnic acid and related compounds

1950 • 11 citations

305. Reactive methylene groups and nitroso-compounds. Abnormal action of acids on 1 : 2 : 3-triketones

1939 • 11 citations

Some biochemical properties of thio analogues of salicylic acid

1965 • 11 citations

Ueber die bakterizide und entwicklungschemmende Wirkung von 1-Rhodinsäure, d-Citronellsäure und Hinokitiol im Vergleich mit Caprinsäure und den ihr naheverwandten Fettsäuren

1948 • 10 citations

Inhibition of transaminases by cinchophen and its derivatives

1965 • 9 citations

Inhibition of glutamate decarboxylase by salicylate congeners

1963 • 8 citations

Struktur und komplexchemisches Verhalten N‐mono‐bzw. N.N‐disubstituierter Anthranilsäuren

1964 • 8 citations

Pharmacological studies of a new analgesic and anti-inflammatory agent, 1-benzylcycloheptimidazol-2(1H)-one, (RCH-314)

1964 • 8 citations

A specific esterase in experimental inflammation

1963 • 8 citations

The metabolism of phenolic antioxidants. 4. The metabolites of gentisic acid in the dog

1964 • 8 citations

The effect of quinones on mitochondrial phosphorylation, Pi-ATP exchange, and ATPase activities

1964 • 7 citations

The polarography of ninhydrin

1950 • 7 citations

Anaphylaxis in Isolated Rat Mast Cells

1963 • 7 citations

Inhibition of enzymatic transphosphorylation by alloxan and ninhydrin in tissue extracts.

1949 • 6 citations

Ueber Einwirkung des Broms auf Orthoamidosulfobenzolsäure

1876 • 6 citations

Evaluation of the method of rivanol precipitation of [35S] sulphated mucopolysaccharides present in the material obtained from a small group of cells

1964 • 6 citations

Effect of alloxan on mitochondrial adenosinetriphosphatase activity and the ATP-ADP exchange reaction

1966 • 5 citations

Verhalten eines gewebseigenen, Ester-hydrolysierenden Enzym-systems bei Gewebssch�digung und dessen Beeinflussung durch Antiphlogistica

1966 • 5 citations

The Relation Between Chemical Structure and Uncoupling Activity in Congeners of Salicylate

1961 • 5 citations

2,4,6-Trihydroxybenzoic Acid in the Treatment of Rheumatic Fever

1960 • 5 citations

Chemobiodynamics and drug design

1961 • 4 citations

Molecular Biology in China

1965 • 4 citations

�ber die bakteriostatische Wirkung einiger Tropolonverbindungen und das Verhalten der bakteriellen Resistenz gegen dieselben

1953 • 3 citations

670. The synthesis of γ-resorcylic acid (2 : 6-dihydroxybenzoic acid)

1952 • 3 citations

Über die Ausscheidung von Ketoindolen und ihren Abkömmlingen

1941 • 2 citations