Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

THE ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN THE MOUSE

1968 • 1,244 citations

Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

1971 • 940 citations

Prostaglandins: Their Disappearance from and Release into the Circulation

1967 • 898 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

A SENSITIVE METHOD FOR THE ASSAY OF 5‐HYDROXYTRYPTAMINE

1957 • 773 citations

The release and fate of vaso‐active hormones in the circulation

1969 • 639 citations

Prostaglandins released by the Spleen

1968 • 542 citations

THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD

1964 • 478 citations

Release of a Prostaglandin E-Like Substance from Canine Kidney by Bradykinin

1972 • 354 citations

Cutaneous reactions to intradermal prostaglandins

1971 • 337 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

Recovery of Prostaglandins in Human Cutaneous Inflammation

1971 • 206 citations

SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN.

1964 • 206 citations

Inflammation mechanisms and control

1974 • 189 citations

A SENSITIVE METHOD FOR THE ASSAY OF ANGIOTENSIN

1964 • 180 citations

Spontaneous and evoked release of prostaglandins from frog spinal cord

1966 • 174 citations

Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized cats

1966 • 167 citations

Action of Prostaglandin E1 on Tissues which respond to Bradykinin

1963 • 139 citations

THE OCCURRENCE OF PROSTAGLANDIN E₂ IN SPLENIC VENOUS BLOOD OF THE DOG FOLLOWING SPLENIC NERVE STIMULATION

1968 • 130 citations

Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen

1973 • 124 citations

ACTION OF PROSTAGLANDIN IN THE PREGNANT WOMAN

1971 • 123 citations

PROSTAGLANDIN ‐ NOREPINEPHRINE INTERACTIONS IN BRAIN: MICROELECTROPHORETIC AND HISTOCHEMICAL CORRELATES

1971 • 110 citations

Nociceptive Response to Prostaglandins and Analgesic Actions of Aspirin and Morphine

1972 • 100 citations

Prostaglandins and the Aspirin-Like Drugs

1972 • 81 citations

THE NATURE OF HEPATIC AND SPLENIC SYMPATHIN

1950 • 79 citations

A Pharmacological Analysis of Aspirin

1970 • 65 citations

Bradykinin Writhing: A Method for Measuring Analgesia.

1963 • 63 citations

MEASUREMENT OF THE EFFECT ON THE PAIN THRESHOLD OF ACETYLSALICYLIC ACID, ACETANILID, ACETOPHENETIDIN, AMINOPYRINE, ETHYL ALCOHOL, TRICHLORETHYLENE, A BARBITURATE, QUININE, ERGOTAMINE TARTRATE AND CAFFEINE: AN ANALYSIS OF THEIR RELATION TO THE PAIN EXPERIENCE

1941 • 62 citations

Prostaglandin-oxytocin Enhancement and Potentiation and their Clinical Applications

1972 • 60 citations

The continuous bioassay of the release and disappearance of histamine in the circulation

1973 • 47 citations

Rapid Induction by Acetylcholine, Bradykinin and Potassium of a Nociceptive Response in Mice and its Selective Antagonism by Aspirin

1964 • 41 citations

Profiles of Activity in Rodents of Some Narcotic and Narcotic Antagonist Drugs

1969 • 39 citations

VASCULAR REFLEX RESPONSES INDUCED BY AN INTRAARTERIAL INJECTION OF AZAAZEPINOPHENOTHIAZINE, ANDROMEDOTOXIN, VERATRIDINE, BRADYKININ AND KALLIKREIN AND BLOCKING ACTION OF SODIUM SALICYLATE

1964 • 25 citations

Anti-Inflammatory Effects Of Romilar Cf**Department of Pharmacology, Hoffmann-La Roche, Inc., Nutley 10, N. J.

1958 • 10 citations

Evaluation of analgesic substances.

1960 • 8 citations