A Pharmacological Analysis of Aspirin

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

1962 • 5,670 citations

Versuchsanordnung zu Untersuchungen an der Bronchiàlmuskulatur

1940 • 660 citations

The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shock

1960 • 638 citations

EFFECTS OF SALICYLATES ON HUMAN PLATELETS

1968 • 564 citations

Physiology of Temperature Regulation

1961 • 534 citations

A Method for Evaluating both Non-Narcotic and Narcotic Analgesics

1957 • 493 citations

The pharmacological basis of therapeutics

1966 • 412 citations

Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulation

1964 • 407 citations

Pathogenesis of Fever

1960 • 390 citations

IMPAIRED PLATELET/CONNECTIVE-TISSUE REACTION IN MAN AFTER ASPIRIN INGESTION

1967 • 376 citations

Inhibition of Adenosine Diphosphate-Induced Secondary Aggregation and Other Platelet Functions by Acetylsalicylic Acid Ingestion

1968 • 327 citations

A New Concept of Temperature Regulation by Amines in the Hypothalamus

1963 • 301 citations

GASTROSCOPIC OBSERVATION OF THE EFFECT OF ASPIRIN AND CERTAIN OTHER SUBSTANCES ON THE STOMACH

1938 • 299 citations

The Control of Lipid Metabolism

1963 • 298 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1953 • 265 citations

SALICYLATES AND BLEEDING

1966 • 253 citations

Changes in temperature produced by micro‐injections of amines into the anterior hypothalamus of cats

1965 • 228 citations

Human Gastric Function

1960 • 217 citations

Fecal Blood Loss Produced by Oral and Intravenous Administration of Various Salicylates

1961 • 213 citations

Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5‐HT on body temperature in conscious rabbits.

1965 • 206 citations

Clinical measurement of the anti-inflammatory effects of salicylates in rheumatoid arthritis.

1967 • 204 citations

Inhibition of the anaphylactic reaction

1957 • 183 citations

Aspirin and gastrointestinal bleeding

1961 • 181 citations

Observations on the site and mode of action of pyrogens in the rabbit brain

1967 • 179 citations

Effect of salicylates in urticaria.

1967 • 163 citations

Aspirin and Ulcer

1955 • 157 citations

Displacement of One Drug by Another from Carrier or Receptor Sites

1965 • 152 citations

EFFECT OF ANTI-INFLAMMATORY AGENTS ON PLATELETS

1968 • 148 citations

Suppression of Pain by Sound

1960 • 143 citations

Pharmakologisches über Aspirin (Acetylsalicylsäure)

1899 • 142 citations

Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin.

1967 • 138 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1953 • 131 citations

XXXII. An account of the success of the bark of the willow in the cure of agues. In a letter to the Right Honourable George Earl of Macclesfield, President of R. S. from the Rev. Mr. Edward Stone, of Chipping-Norton in Oxfordshire

1763 • 129 citations

A Possible Basis for the Anti-inflammatory Activity of Salicylates and other Non-Hormonal Anti-Rheumatic Drugs

1958 • 126 citations

Methods of Drug Evaluation

1967 • 118 citations

STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE

1943 • 114 citations

The Toxic Effects of Phenylbutazone (Butazolidin)

1955 • 110 citations

Salicylates and Gastro-intestinal Bleeding

1962 • 107 citations

THE PHARMACOLOGY OF PHENYLBUTAZONE ANALOGUES

1960 • 105 citations

Pain and analgesia evaluated by the intraperitoneal bradykinin‐evoked pain method in man

1967 • 100 citations

Biochemical properties of anti-inflammatory drugs—II

1964 • 99 citations

Aspirin and gastric bleeding

1961 • 97 citations

The demonstration of the role of mediators in turpentine pleurisy in rats by experimental suppression of the inflammatory changes

1959 • 96 citations

Antagonism by Aspirin and Fenamates of Bronchoconstriction and Nociception induced by Adenosine-5′-triphosphate

1966 • 96 citations

The uptake of ( ³⁵ S) sulphate by mucopolysaccharides of granulation tissue

1955 • 87 citations

The Salicylates: A Critical Bibliographic Review

1949 • 86 citations

Latency of Pyrogen Fever. Appearance of a Fast-Acting Pyrogen in the Blood of Febrile Animals and in Plasma Incubated With Bacterial Pyrogen

1953 • 85 citations

OPPOSITE ACTIONS OF THYROID AND ADRENAL HORMONES IN ALLERGIC HYPERSENSITIVITY

1950 • 84 citations

Uricosuric Drugs, with Special Reference to Probenecid and Sulfinpyrazone

1966 • 84 citations

Salicylates and Thyroid Function. I. Depression of Thyroid Function

1958 • 83 citations

Fever produced by microinjection of typhoid vaccine into hypothalamus of cats

1965 • 82 citations

The Salicylates: A Critical Bibliographic Review

1967 • 80 citations

RENAL IRRITATION CAUSED BY SALICYLATES

1963 • 78 citations

THE TREATMENT OF ACUTE RHEUMATISM BY SALICIN.

1876 • 75 citations

Production of Hypoprothrombinemia and Hypoeoagulability of the Blood with Salicylates.

1943 • 73 citations

Renal Biopsy in Rheumatoid Arthritis

1965 • 73 citations

Effect of various drugs on carrageenin-induced oedema in the rat hind paw

1964 • 73 citations

HISTOLOGICAL CHANGES IN RABBIT KIDNEYS INDUCED BY PHENACETIN AND ACETYLSALICYLIC ACID

1964 • 72 citations

Aspirin Preparations and Their Noxious Effect on the Gastro-intestinal Tract

1962 • 70 citations

Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs

1966 • 70 citations

Effect of Cortisone on Some Reactions of Hypersensitivity in Laboratory Animals.

1950 • 68 citations

The Effect of Salicylates upon the Stomachs of Dogs

1964 • 65 citations

Anti‐inflammatory and antipyretic properties of N‐(α,α,α‐Trifluoro‐m‐tolyl) anthranilic acid (CI‐440; flufenamic acid)

1963 • 65 citations

THE STRESS RESPONSE IN THE SEVERELY BURNED

1951 • 65 citations

Necrosis of the Renal Papillae in Rheumatoid Arthritis

1961 • 64 citations

TISSUE REACTIONS TO ANAPHYLACTIC AND ANAPHYLACTOID STIMULI; PROTEOLYSIS AND RELEASE OF HISTAMINE AND HEPARIN

1955 • 63 citations

Bradykinin Writhing: A Method for Measuring Analgesia.

1963 • 63 citations

Ueber eine neue Darstellungsmethode und einige bemerkenswerte Eigenschaften der Salicylsäure

1874 • 62 citations

Chronic Hemolytic Anemia due to Cold Agglutinins: the Mechanism of Resistance of Red Cells to C′ Hemolysis by Cold Agglutinins*

1967 • 62 citations

A vascular permeability factor extracted from normal and sensitized guinea-pig lymph node cells

1962 • 60 citations

The effect of salicylate on glycosuria, blood glucose and liver glycogen of the alloxan-diabetic rat

1952 • 60 citations

ANALGESIC ABUSE AND RENAL DISEASE IN NORTH-EAST SCOTLAND

1966 • 60 citations

Temperature effects produced in dogs and monkeys by injections of monoamines and related substances into the third ventricle

1967 • 59 citations

Topical Action of Salicylates in Gastrointestinal Erosion and Hemorrhage

1963 • 58 citations

The permeability to plasma proteins of the peritoneal blood vessels of the mouse, and the effect of substances that alter permeability

1963 • 53 citations

The nephrotoxicity of analgesics

1966 • 51 citations

Influence of Aspirin on Haemostatic Parameters

1964 • 51 citations

Blockade of bradykinin-induced nociception in the rat as a test for analgesic drugs with particular reference to morphine antagonists

1967 • 51 citations

Salicylates, stress and cortisone

1950 • 50 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1958 • 50 citations

Allergy in Theory and Practice

1947 • 49 citations

Anti-histamine effect of sodium salicylate and its bearing upon the skin-diffusing activity of hyaluronidase

1948 • 49 citations

The effect of bradykinin in an isolated perfused dog lung preparation

1961 • 49 citations

Studies on Algesimetry by Electrical Stimulation of the Mouse Tail

1961 • 48 citations

Hypoprothrombinemia After Salicylate Administration in Man and Rabbits

1943 • 48 citations

Serotonine and Temperature Control

1966 • 47 citations

The Analgesic and Antipyretic Properties of Some Derivatives of Salicylamide

1952 • 47 citations

Analytical Review: Lysosomes

1964 • 46 citations

The effect of ribonucleic acid on vascular permeability and its possible relationship to LNPF

1965 • 46 citations

OBSERVATIONS ON THE PRODUCTION OF PYROGENIC SUBSTANCES BY RABBIT AND HUMAN LEUCOCYTES

1961 • 45 citations

Action of Salicylates and Related Drugs on Inflammation

1952 • 45 citations

Comparative Effects of Some Immunosuppressive and Anti-Inflammatory Drugs on Allergic Encephalomyelitis and Adjuvant Arthritis

1967 • 44 citations

THE ROLE OF ENDOGENOUS PYROGEN IN THE GENESIS OF FEVER

1958 • 43 citations

Influence of Phenylbutazone on Gastric Secretion of Mucus.

1967 • 42 citations

Rapid Induction by Acetylcholine, Bradykinin and Potassium of a Nociceptive Response in Mice and its Selective Antagonism by Aspirin

1964 • 41 citations

ACETYLSALICYLIC ACID AND PLATELET STICKINESS

1967 • 40 citations

Effect of Aspirin on Cutaneous Response to the Local Application of an Ester of Nicotinic Acid

1959 • 39 citations

Antagonists of bradykinin

1962 • 39 citations

Anti-Inflammatory Effects of Counterirritants

1958 • 38 citations

EFFECTIVENESS OF SALICYLAMIDE AS AN ANALGESIC AND ANTIRHEUMATIC AGENT

1955 • 37 citations

The use of bradykinin-induced effects in rats as an assay for analgesic drugs

1966 • 37 citations

SALICYLATE TOXICITY: THE PROBABLE MECHANISM OF ITS ACTION

1946 • 37 citations

Effet des analgésiques non narcotiques sur l'hypotension due à la bradykinine

1966 • 36 citations

SOME RECENT ADVANCES IN THE PHARMACOLOGY OF SALICYLATES

1953 • 35 citations

Analgesic-Antipyretics

1960 • 35 citations

Effect of Aspirin Upon Glycosuria of the Partially Depancreatized Rat

1950 • 35 citations

Aspirin and Algesimetry

1959 • 34 citations

The Effect of Bradykinin, Kallidin and Eledoisin upon the Pulmonary Vascular Bed of an Isolated Blood-Perfused Rabbit Lung Preparation

1966 • 34 citations

THE INFLUENCE OF SODIUM SALICYLATE AND ACETYL SALICYLIC ACID ON THE RELEASE OF HISTAMINE IN ANAPHYLAXIS

1951 • 33 citations

Suppression of the Phenomenon of Local Tissue Reactivity by ACTH, Cortisone and Sodium Salicylate

1950 • 32 citations

Pyretogenic effects of bacterial lipopolysaccharide and the assay of antipyretic drugs in rats

1963 • 32 citations

The mechanism of body temperature changes induced by intraventricular injections of adrenaline, noradrenaline and 5‐hydroxytryptamine in the ox (bos taurus)

1967 • 32 citations

ACTH AND CORTISONEVS. SALICYLATES

1952 • 31 citations

The effect of bradykinin and anti-inflammatory agents on isolated arteries

1966 • 31 citations

The action of analgesic substances on the gastric mucosa

1966 • 31 citations

Effect of paracetamol (N-acetyl-p-aminophenol) on gastrointestinal bleeding

1964 • 30 citations

Indomethacin, a new anti-inflammatory drug: Its potential use as a laboratory tool

1965 • 30 citations

A clinical comparison of the antipyretic potency of aspirin and sodium salicylate

1965 • 30 citations

Synthetic Anti-Inflammatory Drugs: Concepts of Their Mode of Action

1966 • 29 citations

THE PHARMACOLOGY OF SALICYLATES AND RELATED COMPOUNDS*

1960 • 29 citations

Pharmakotherapeutische Weiterentwicklung der Antipyretica-Antalgetica

1955 • 28 citations

Effect of Aspirin on Suprathreshold Pain in Man

1958 • 28 citations

The role of the nervous system in local inflammatory responses

1965 • 27 citations

Über die Stimulierung der Atmung durch Bradykinin und Kallidin

1964 • 27 citations

The effect of tissue extracts on vascular permeability and leucocyte emigration

1965 • 26 citations

Anti-anaphylactic Action of Acetylsalicylate in Guinea Pig Lung

1963 • 26 citations

PLASMA-SALICYLATE CONCENTRATIONS AFTER SMALL DOSES OF ACETYLSALICYLIC ACID

1951 • 26 citations

Effect of Indomethacin in Endotoxin Shock in the Dog.

1967 • 25 citations

Inhibition of Anaphylactic Shock by Acetylsalicylic Acid

1948 • 25 citations

INHIBITION OF THE PHENOMENON OF LOCAL TISSUE REACTIVITY BY CORTICOSTEROIDS, SALICYLATES, AND COMPOUNDS RELATED TO SALICYLATES

1953 • 24 citations

A Method for Testing Analgesics in Rheumatoid Arthritis using a Sequential Procedure

1959 • 24 citations

The effect of salicylate on the glycosuria and hyperglycaemia induced by cortisone in the normal rat

1952 • 23 citations

Carbohydrate Metabolism in Experimental Salicylism.

1955 • 23 citations

Curtailment by aspirin and meclofenamate of hypotension induced by bradykinin in the guinea pig

1968 • 22 citations

The production of eosinophilic deposits resembling fibrinoid by injections of lymph‐node extracts

1964 • 22 citations

Studies on the Antipyretic Action of Salicylates.

1967 • 22 citations

Structure-action Relationships among Drugs acting on Connective Tissues (Anti-rheumatic Agents)

1962 • 21 citations

Aspirin

1963 • 20 citations

A New Concept of Temperature Control in the Hypothalamus

1965 • 19 citations

Effects on Anaphylactic Shock of Salicylates, Aminopyrine and Other Chemically and Pharmacologically Related Compounds.

1950 • 19 citations

Apnoe nach Bradykinin und Kallidin

1964 • 18 citations

An Improved Analytical Procedure for Automatic Analysis of Amino Acids

1966 • 18 citations

Reversal by acetylsalicylic acid of pain induced functional impairment

1966 • 18 citations

Possible Mechanisms of the Therapeutic Action of Cortisone

1955 • 18 citations

Ueber das Verhalten einiger Säuren im thierischen Organismus

1856 • 17 citations

Aspirin and gastric bleeding: Further studies of calcium aspirin

1961 • 16 citations

Suppression of Glycosuria During Administration of Large Doses of Aspirin to Force-Fed Partially Depancreatectomized Rats

1952 • 16 citations

Effect of Anti-inflammatory Agents on Capillary Permeability and Œdema Formation

1964 • 16 citations

The Mechanism of the Anti-Inflammatory Activity of Salicylate

1961 • 15 citations

Aspirin and Gastric Haemorrhage

1943 • 15 citations

How to Manage Pain in Malignant Disease

1961 • 14 citations

The Regulation of Human Respiration

1964 • 14 citations

HYPOPROTHROMBINEMIA INDUCED IN SUCKLING RATS BY FEEDING 3,3'-METHYLENEBIS(4-HYDROXYCOUMARIN) AND ACETYLSALICYLIC ACID TO THEIR MOTHERS

1945 • 14 citations

DIE WIRKUNG VON BRADYKININ‐AEROSOL AUF DIE ATMUNG DES MENSCHEN UND DES MEER‐SCHWEINCHENS UND DER EINFLUSS VER‐SCHIEDENER SUBSTANZEN AUF DEN EXPERI‐MENTELLEN BRADYKININ‐BRONCHOSPASMUS

1963 • 13 citations

Zum Wirkungsmechanismus großer Salizylatdosen¹

1952 • 12 citations

Salicyates and Carbohydrate Metabolism

1952 • 12 citations

Gastrointestinal Bleeding in Normal Subjects: A Comparison of Aspirin and Mefenamic Acid

1964 • 12 citations

Antagonism of anti-inflammatory drugs on bradykinin-induced increase of capillary permeability

1967 • 11 citations

Effect of Non-Steroidal Anti-Inflammatory Drugs in the Evans Blue Pleural Effusion

1966 • 11 citations

Effect of acute and prolonged salicylate administration on liver and plasma triglyceride levels and diet-induced hypercholesterolemia

1967 • 10 citations

Untersuchungen zum Mechanismus der Atemwirkung des Anaphylatoxins

1968 • 10 citations

Ischemic arm pain and the nonnarcotic analgesic mefenamic acid, N-(2,3-Xylyl)anthranilic acid

1965 • 10 citations

The Comparative Antipyretic Activity of Acetylsalicylic Acid and Salycylamide in Feverinduced Rats

1957 • 10 citations

GASTRO‐INTESTINAL BLEEDING: A COMPARISON OF MEFENAMIC ACID AND ASPIRIN

1967 • 10 citations

Drug Addiction

1965 • 10 citations

INTESTINAL BLEEDING ASSOCIATED WITH ACETYLSALICYLIC ACID

1951 • 9 citations

Zur Wertbestimmung der Analgetika und ihrer Kombinationen

1933 • 9 citations

Ischemic arm pain and nonnarcotic analgesics

1959 • 9 citations

ANTIPYRETICS. III. ACETYLSALICYLIC ACID AND HEAT REGULATION IN FEVER CASES

1919 • 9 citations

Der Einflu� der Narkose auf die Wirkung von Natriumsalicylat und Phenylbutazon (Butazolidin Geigy) am experimentellen Pfoten�dem der Ratte

1957 • 9 citations

A biological method for the evaluation of the nonnarcotic analgesics

1955 • 9 citations

Zur Frage der Entstehung der vagal-reflektorischen Bradykinin-Tachypnoe

1966 • 9 citations

A Hypersensitivity Phenomenon Produced by Stress: The “Negative Phase” Reaction

1960 • 8 citations

Hemmung der Phagocytose durch Butazolidin und andere Antiphlogistica

1957 • 8 citations

Essais d'inhibition de l'action inflammatoire cutanée du chloroforme chez le rat

1954 • 7 citations

�ber die Bradykinin-Wirkung am Herz-Lungen-Pr�parat des Meerschweinchens

1962 • 7 citations

Action antiinflammatoire comparée de l'A.C.T.H., de la cortisone et du salicylate de soude

1952 • 7 citations

The evaluation of Antipyretics Against Pyrogen‐Induced Fever*

1946 • 6 citations

Influence of Magnesium Salts Upon the Toxicity and Antipyretic Action of the Salicylates.

1928 • 5 citations

Anti-Inflammatory Activity of 2,4-Dinitrophenol following Local Administration at the Site of Inflammation

1968 • 4 citations

Use of time-response relationships in assessing pharmacological activity

1965 • 4 citations

Effect of Sodium Salicylate on Intradermal Reactions of Rabbits.

1930 • 4 citations

Influence of Salicylate on Cortisol Secretion in the Dog

1962 • 4 citations

Nonsteroidal anti‐inflammatory drugs

1993 • 4 citations

Ein Beitrag zur Kenntniss der antifebrilen Wirksamkeit der Salicylsäure

1875 • 3 citations

Effects of Salicylate on Prophylactic Counter-Irritation.

1961 • 3 citations

Influence of Magnesium Oxide on Antipyretic Action and Toxicity of Acetylsalicylic Acid in Rabbits

1936 • 3 citations