Search for Common Mechanisms Underlying the Various Effects of Putative Inflammatory Mediators

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

1962 • 5,670 citations

The aggregation of blood platelets

1963 • 2,125 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

1971 • 1,433 citations

Lipid peroxidation damage to cell components.

1973 • 925 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shock

1960 • 638 citations

Interaction of anti-inflammatory drugs with serum proteins, especially with some biologically active proteins

1968 • 492 citations

A BRADYKININ‐POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARACA

1965 • 488 citations

Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom

1971 • 480 citations

THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD

1964 • 478 citations

THE LIBERATION OF A SLOW‐REACTING SMOOTH MUSCLE‐STIMULATING SUBSTANCE IN ANAPHYLAXIS

1940 • 416 citations

Liberation of histamine and formation of lysocithin‐like substances by cobra venom

1938 • 372 citations

Role of Adenosine Diphosphate in the Aggregation of Human Blood-Platelets by Thrombin and by Fatty Acids

1964 • 343 citations

Inhibition of Adenosine Diphosphate-Induced Secondary Aggregation and Other Platelet Functions by Acetylsalicylic Acid Ingestion

1968 • 327 citations

Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation

1973 • 318 citations

Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle

1973 • 275 citations

The Blood Platelet Release Reaction

1969 • 260 citations

Selective inhibition by mepacrine of the release of “rabbit aorta contracting substance” evoked by the administration of bradykinin

1972 • 249 citations

Platelet Aggregation induced by Arachidonic Acid is accompanied by Release of Potential Inflammatory Mediators distinct from PGE2 and PGF2

1973 • 227 citations

Damage to proteins, enzymes, and amino acids by peroxidizing lipids

1966 • 214 citations

FACTORS REGULATING THE BIOSYNTHESIS OF VARIOUS PROSTAGLANDINS

1971 • 203 citations

Inhibition of the anaphylactic reaction

1957 • 183 citations

Formation of Prostaglandins during the Aggregation of Human Blood Platelets

1973 • 180 citations

Relationship between chemical structure and plateletaggregation activity of prostaglandins

1969 • 178 citations

ALTERATION OF THE RESPONSE OF PLATELETS TO SURFACE STIMULI BY PYRAZOLE COMPOUNDS

1967 • 171 citations

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG

1961 • 146 citations

Influence of Apyrase on Stability of Suspensions of Washed Rabbit Platelets

1971 • 145 citations

ANALGESIC ANTIPYRETIC DRUGS AS ANTAGONISTS OF BRADYKININ

1960 • 137 citations

PLATELET-DEPENDENT GENERATION OF CHEMOTACTIC ACTIVITY IN SERUM

1973 • 135 citations

RELEASE PROCESSES IN MAST CELLS AND THEIR ACTIVATION BY INJURY

1964 • 134 citations

Synthesis and biological activity of peptides related to bradykinin

1960 • 133 citations

Characterization of Human Platelet Vascular Permeability-Enhancing Activity

1972 • 128 citations

Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) by IgE-Anti-IgE Reactions on Monkey Mast Cells

1972 • 127 citations

Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin induced inflammation in the rat

1971 • 122 citations

Release of Vasoactive Substances from Guinea-Pig Lungs by Slow-Reacting Substance C and Arachidonic Acid

1971 • 117 citations

Inhibition of Allergic Reactions in Man and Other Species by Cromoglycate

1970 • 113 citations

BRONCHOCONSTRICTOR ACTION AND ANTAGONISM OF A SLOW‐REACTING SUBSTANCE FROM ANAPHYLAXIS OF GUINEA‐PIG ISOLATED LUNG

1964 • 112 citations

Effect of unsaturated fatty acids and their peroxides on enzymes

1961 • 112 citations

Biosynthesis of prostaglandins.

1972 • 109 citations

The formation of lysocithin and of a muscle-stimulating substance by snake venoms

1938 • 108 citations

Isolation of a chemical trigger for thrombosis

1974 • 103 citations

Susceptibility of erythrocytes of various animal species to the hemolytic and phospholipid splitting action of snake venom

1964 • 102 citations

Effect of Prostaglandin E2 and Aspirin on the Secondary Aggregation of Human Platelets

1972 • 101 citations

Disodium Cromoglycate, an Inhibitor of Mast Cell Degranulation and Histamine Release induced by Phospholipase A

1969 • 97 citations

Release of Permeability Factors from the Blood Platelet

1965 • 96 citations

Antagonism by Aspirin and Fenamates of Bronchoconstriction and Nociception induced by Adenosine-5′-triphosphate

1966 • 96 citations

Effects of dibutyryl-3',5'-cyclic adenosine monophosphate, phosphodiesterase inhibitors and prostaglandin E1 on compound 4880-induced histamine release from rat peritoneal mast cells invitro

1971 • 95 citations

Phospholipase-A activity of mammalian tissues

1965 • 94 citations

A permeability factor released from leukocytes after phagocytosis of immune complexes and its possible role in the Arthus reaction

1964 • 93 citations

Release reactions of human platelets induced by thrombin and other agents

1968 • 88 citations

Myocardial phospholipase a of microsomal and mitochondrial fractions

1971 • 86 citations

Potentiation of bradykinin by dimercaptopropanol (BAL) and other inhibtors of its destroying enzyme in plasma

1962 • 83 citations

Release of histamine, kinin and prostaglandins during carrageenin-induced inflammation in the rat.

1969 • 83 citations

Venom phospholipase A: A review

1965 • 80 citations

Synergism between phospholipase A and various peptides and SH-reagents in causing haemolysis

1970 • 77 citations

THE PLATELET AS AN INFLAMMATORY CELL*

1972 • 75 citations

Antigen Induced Histamine Release from Platelets of Rabbits Producing Homologous PGA Antibody.

1966 • 72 citations

A study of pharmacological influences on ultraviolet erythema in guinea pigs.

1958 • 69 citations

Some Biochemical and Pharmacological Properties of Anti-Inflammatory Drugs

1965 • 69 citations

Acid lipase and phospholipase activity in homogenates of rabbit polymorphonuclear leukocytes

1963 • 67 citations

SOME ELECTRON MICROSCOPIC OBSERVATIONS ON INTERACTIONS BETWEEN LEUKOCYTES, PLATELETS, AND ENDOTHELIAL CELLS IN ACUTE INFLAMMATION*

1964 • 66 citations

The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins

1972 • 66 citations

Calcium independent phospholipase A 2 activity in rat lung supernatant.

1972 • 63 citations

Acetylenic inhibitors of sheep vesicular gland oxygenase

1973 • 63 citations

Pharmacologically active substances formed in egg yolk by cobra venom

1957 • 63 citations

Some properties of phospholipases of alveolar macrophages

1973 • 62 citations

Pharmacological studies in inflammation due to exposure to ultraviolet radiation

1970 • 62 citations

Lipid peroxide formation in experimental inflammation

1972 • 62 citations

Inhibition in vivo of the enzymatic inactivation of bradykinin and kallidin

1963 • 61 citations

Some pharmacodynamic properties of carrageenin in the rat

1970 • 57 citations

Some effects of ethanol and carbon tetrachloride on lipoperoxidation in rat liver

1969 • 56 citations

Evidence for the presence of prostaglandin-like material in the plasma of dogs with endotoxin shock.

1973 • 53 citations

The anticoagulant activity of carrageenan

1965 • 53 citations

Effect of Drugs on Mast Ceils

1967 • 53 citations

Prostaglandin: Liberation from and formation in perfused frog intestine

1970 • 50 citations

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG

1961 • 49 citations

Antagonism by fenamates and like‐acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea‐pig

1968 • 48 citations

Non-steroidal anti-inflammatory drugs and leucocyte emigration

1972 • 45 citations

INHIBITION OF PLASMA KININASE ACTIVITY AT SLIGHTLY ACID pH

1962 • 43 citations

THE EFFECT OF ANTI‐INFLAMMATORY DRUGS ON VASCULAR SMOOTH MUSCLE

1967 • 43 citations

RELATION OF CYCLIC AMP TO THE RELEASE AND ACTIONS OF PROSTAGLANDINS*

1971 • 43 citations

Anti-inflammatory Activity of d-α-Tocopherol (Vitamin E) and Linoleic Acid

1967 • 42 citations

A Novel in vitro Assay for Anti-Inflammatory Agents Based on Stabilization of Erythrocytes

1967 • 41 citations

Reduction of prostaglandin-phase in hind-paw inflammation and partial failure of indomethacin to exert anti-inflammatory effect in rats on essential fatty acid deficient diet

1974 • 41 citations

Appearance of prostaglandins in the renal venous blood of dogs in response to acute systemic hypotension produced by bleeding or endotoxin.

1973 • 40 citations

Antagonists of bradykinin

1962 • 39 citations

The isolation of a haemolytic substance from animal tissues and its biological properties

1949 • 38 citations

Purification ct propriétés physico-chimiques, chimiques et biologiques d'une phospholipase A2 toxique isolée d'un venin de serpent Viperidae: Vipera berus

1973 • 36 citations

INHIBITION BY NON‐STEROID ANTI‐INFLAMMATORY AGENTS OF RABBIT AORTA CONTRACTING ACTIVITY GENERATED IN BLOOD BY SLOW REACTING SUBSTANCE C

1974 • 34 citations

HISTAMINE RELEASE BY BEE VENOM PHOSPHOLIPASE A AND MELLITIN IN THE RAT

1965 • 33 citations

Inhibition of the Anaphylactic Release of Histamine from Chopped Guinea Pig Lung by Chymotrypsin Substrates and Inhibitors

1960 • 33 citations

Anti-inflammatory action of sulfated polysaccharides

1969 • 33 citations

ANALGESIC‐ANTIPYRETIC DRUGS AS INHIBITORS OF KALLIKREIN

1961 • 32 citations

Bradykininogen and bradykinin in the cardiovascular shock produced by proteolytic enzymes

1966 • 31 citations

Cellular mechanisms involved in the release of slow reacting substance of anaphylaxis.

1969 • 30 citations

Changes in plasma phospholipids after intravenous phosphatidase A injection in the rabbit

1962 • 29 citations

Role of complement and leukocytes in immunologic release of vasoactive amines from platelets.

1969 • 28 citations

Haemorrhagic mechanisms of some snake venoms in relation to protection by estriol succinate of blood vessel damage

1969 • 26 citations

Arachidonic acid, an unsaturated fatty acid which produces slow contractions of smooth muscle and causes pain. Pharmacological and biochemical characterisation of its mode of action.

1959 • 26 citations

STUDIES ON KALLIKREIN: FAILURE OF SOME ANTI‐INFLAMMATORY DRUGS TO AFFECT RELEASE OF KININ

1966 • 25 citations

COMPARISON OF HAEMOLYSIS AND LIBERATION OF HISTAMINE BY TWO AUSTRALIAN SNAKE VENOMS

1939 • 24 citations

Pharmacological evidence for a vasodilator receptor to serotonin in the nasal vessels of the dog

1974 • 23 citations

Curtailment by aspirin and meclofenamate of hypotension induced by bradykinin in the guinea pig

1968 • 22 citations

Action des plaquettes sur la prophospholipase plasmatique

1972 • 22 citations

Ultraviolet Light: A New Stimulus for the Induction of Platelet Aggregation

1971 • 21 citations

Inhibition of mast-cell degranulation by anti-inflammatory agents.

1967 • 21 citations

Paradoxical inhibition of the effects of bradykinin by some sulfhydryl reagents

1972 • 20 citations

PHYSIOLOGIC RESPONSES OF CERTAIN ANIMALS AND ISOLATED PREPARATIONS TO MIXTURES OF SNAKE VENOM AND EGG YOLK

1950 • 20 citations

On the mode of action and biochemical properties of anti-inflammatory drugs-I

1973 • 20 citations

Significance of the kinin system in rat paw oedemas and drug effects on it

1967 • 19 citations

Platelets, Prostaglandins, Red Cells, Sedimentation Rates, Serum and Tissue Proteins and Non-Steroidal Anti-Inflammatory Drugs

1972 • 19 citations

Effect of Lysolecithin on the Smooth Muscle Stimulating Activity of Histamine, Acetylcholine, 5-Hydroxy-Tryptamine, Anaphylactic Slow-Reacting Substance And Bradykinin

1963 • 18 citations

Distribution and Properties of Anaphylactic and Venom-Induced Slow-Reacting-Substance and Histamine in Guinea Pigs

1964 • 18 citations

Plasmodium berghei: Production in vitro of free fatty acids

1969 • 17 citations

The role of fibrin in the inflammatory response to carrageenin.

1968 • 17 citations

Efflux of Prostaglandin E, from Cat Paws Perfused with Compound 48/80

1971 • 15 citations

Lipid spasmogens appearing in connection with histamine liberation

1963 • 14 citations

Effect of nonsteroidal anti-inflammatory drugs in endotoxin shock

1968 • 14 citations

Comparison of hemorrhagic factors of the venoms of Naja naja, Agkistrodon piscivorus and Apis mellifera

1970 • 13 citations

Antagonism by anti-inflammatory drugs of tissue slow reacting substance C

1970 • 13 citations

Histamine release induced by synergistic action of kallikrein and phospholipase A.

1969 • 13 citations

The influence of analgesic antipyretic drugs on the responses of guinea-pig lungs to bradykinin.

1966 • 11 citations

AN HEREDITARY ENZYMATIC DEFECT IN RED BLOOD CELLS: ITS RELATION TO CERTAIN DRUG‐INDUCED HEMOLYTIC ANEMIAS*

1958 • 11 citations

Liberation of a bradykinin‐like substance in the circulating blood of dogs by trypsin, chymotrypsin and nagarse

1969 • 11 citations

Inhibition by Adenosine Diphosphate of the Thrombocytopenia induced in Rabbits by Collagen or Thrombin

1968 • 11 citations

Dissociation of Oedema Provoking Factor of Agkistrodon Piscivorus Venom from Kininogenase

1972 • 10 citations

Differences in binding of the direct lytic factor (DLF) of cobra venom (Naja naja) to intact red cells and ghosts

1973 • 10 citations

Differential inhibition of prostaglandin synthetase and soybean lipoxygenase

1972 • 10 citations

Apparent association of activity of anti-inflammatory drugs in a sulfhydryl exchange reaction in vitro and in the guinea pig erythema assay

1970 • 9 citations

Possible implication of glutathione reductase in haemolysis by the direct lytic factor of cobra venom (Naja naja)

1972 • 7 citations

Interference of carrageenin, non-steroidal antiinflammatory drugs and protease inhibitors with the kallikrein-kinin system

1969 • 4 citations

Antagonisme par les analgésiques non-narcotiques de la libération de kinines plasmatiques due au venin de B. jararaca et la kallikréine pancréatique

1967 • 3 citations

Inhibition by cromoglycate of histamine release induced by dextran plus phosphatidyl serine.

1973 • 3 citations

Modification of the fatty acid-induced thrombocytopenia by anticoagulants and compounds which inhibit in vitro platelet aggregation.

1968 • 3 citations

POSSIBLE ROLE OF LECITHIN IN THE DEVELOPMENT OF THE SLOW MUSCLE CONTRACTING ACTIVITY OF HUMAN PLASMA

1967 • 2 citations

Inhibition by Sulfhydryl Reagents of the Effects of Bradykinin, Arachidonic Acid and “Slow Reacting Substance C”

1972 • 2 citations