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Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia

Data up to Jan 2025

Published1993
Citations324
References246

Total Citations Per Year

Abstract

References (246)

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Cell surface antigens: prognostic implications in childhood acute lymphoblastic leukemia

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1981 • 224 citations

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1989 • 223 citations

The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias

1991 • 218 citations

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1989 • 215 citations

The γδT Cell Receptor

1988 • 214 citations

Monoclonal antibody-based therapies of leukemia and lymphoma

1992 • 213 citations

Oncogenic conversion of transcription factors by chromosomal translocations

1991 • 209 citations

Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription.

1983 • 204 citations

Improved survival rate in children with stage III and IV B cell non-Hodgkin's lymphoma and leukemia using multi-agent chemotherapy: results of a study of 114 children from the French Pediatric Oncology Society.

1986 • 204 citations

Pre-B cell leukemia associated with chromosome translocation 1;19

1984 • 203 citations

Human cell-surface glycoprotein with unusual properties

1980 • 201 citations

Detection of minimal residual disease in acute lymphoblastic leukemia by in vitro amplification of rearranged T-cell receptor delta chain sequences

1989 • 200 citations

Towards a better definition of human leucocyte surface molecules

1989 • 198 citations

Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children [see comments]

1992 • 194 citations

Clinical Importance of Myeloid-Antigen Expression in Acute Lymphoblastic Leukemia of Childhood

1991 • 191 citations

Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets.

1979 • 189 citations

Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue.

1985 • 188 citations

Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19).

1990 • 188 citations

Treatment of adult acute lymphoblastic leukemia with intensive cyclical chemotherapy: a follow-up report

1991 • 188 citations

The immunologic detection of minimal residual disease in acute leukemia [published erratum appears in Blood 1990 Nov 1;76(7):1901]

1990 • 186 citations

Identification of a membrane glycoprotein associated with haemopoietic progenitor cells

1985 • 184 citations

Favorable outcome of B-cell acute lymphoblastic leukemia in childhood: a report of three consecutive studies of the BFM group

1992 • 183 citations

RETRACTED ARTICLE: Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells

1992 • 183 citations

Monoclonal antibody OKT-9 recognizes the receptor for transferrin on human acute lymphocytic leukemia cells.

1981 • 178 citations

Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34

1992 • 178 citations

Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells

1991 • 178 citations

A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969.

1988 • 177 citations

Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion

1992 • 174 citations

Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia

1987 • 173 citations

A monoclonal antibody (WT1) for detecting leukemias of T-cell precursors (T-ALL)

1983 • 171 citations

Lymphocyte Development from Stem Cells

1992 • 170 citations

A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow

1985 • 170 citations

Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse [see comments]

1991 • 169 citations

Heterogeneity of presenting features and their relation to treatment outcome in 120 children with T-cell acute lymphoblastic leukemia

1990 • 168 citations

Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein.

1988 • 167 citations

Cellular phenotypes of normal and leukemic hemopoietic cells determined by analysis with selected antibody combinations

1980 • 167 citations

Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2

1988 • 164 citations

The Gene for Enhancer Binding Proteins E12/E47 Lies at the t(1;19) Breakpoint in Acute Leukemias

1989 • 159 citations

Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a Pediatric Oncology Group Study

1986 • 158 citations

HYBRID ACUTE LEUKAEMIA

1987 • 157 citations

Treatment of acute lymphoblastic leukemia in adults: results of the L-10 and L-10M protocols.

1983 • 155 citations

Acute myeloid leukemia with T-lymphoid features: a distinct biologic and clinical entity

1988 • 155 citations

Terminal Transferase Enzyme Assay and Immunological Membrane Markers in the Diagnosis of Leukaemia: a Multiparameter Analysis of 300 Cases

1980 • 154 citations

T Cell Surface Markers on Lymphoblasts from Acute Lymphocytic Leukemia

1973 • 154 citations

Flow cytometric analysis of human bone marrow. IV. Differential quantitative expression of T-200 common leukocyte antigen during normal hemopoiesis.

1988 • 151 citations

In vitro amplification of T cell gamma gene rearrangements: a new tool for the assessment of minimal residual disease in acute lymphoblastic leukemias.

1989 • 150 citations

Gene rearrangements and translocations in lymphoproliferative diseases

1989 • 149 citations

A single monoclonal antibody identifies T-cell lineage of childhood lymphoid malignancies

1983 • 149 citations

An analysis of leukemic cell chromosomal features in infants

1987 • 148 citations

Cytoplasmic expression of the CD3 antigen as a diagnostic marker for immature T-cell malignancies

1988 • 147 citations

Rearrangement of the T-Cell Receptor β-Chain Gene in Non-T-Cell, Non-B-Cell Acute Lymphoblastic Leukemia of Childhood

1985 • 144 citations

The Arrangement of Immunoglobulin and T Cell Receptor Genes in Human Lymphoproliferative Disorders

1987 • 138 citations

The reliability of cytoplasmic CD3 and CD22 antigen expression in the immunodiagnosis of acute leukemia: a study of 500 cases.

1989 • 137 citations

Ambiguous phenotypes and genotypes in 16 children with acute leukemia as characterized by multiparameter analysis

1988 • 137 citations

T cell receptor and immunoglobulin gene rearrangements in acute myeloblastic leukemia.

1986 • 135 citations

Cytogenetics of childhood T-cell leukemia

1988 • 135 citations

Multimarker classification of acute lymphoblastic leukemia: evidence for further T subgroups and evaluation of their clinical significance

1980 • 134 citations

Immunologic classification of lymphocytic leukemias based on monoclonal antibody-defined cell surface antigens

1982 • 133 citations

Treatment of acute lymphoblastic leukemia in adults with intensive induction, consolidation, and maintenance chemotherapy

1989 • 133 citations

Myeloid-associated antigen expression lacks prognostic value in childhood acute lymphoblastic leukemia treated with intensive multiagent chemotherapy

1990 • 133 citations

The structure of the T cell antigen receptor genes in normal and malignant T cells

1986 • 133 citations

Monoclonal antibody characterization of surface antigens in childhood T- cell lymphoid malignancies

1983 • 132 citations

Subpopulations of common acute lymphoblastic leukemia antigen-positive lymphoid cells in normal bone marrow identified by hematopoietic differentiation antigens

1986 • 129 citations

Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia

1992 • 127 citations

Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

1990 • 126 citations

Acute leukaemia with mixed lymphoid and myeloid phenotype

1984 • 125 citations

Phenotypic and genotypic heterogeneity in infant acute leukemia. I. Acute lymphoblastic leukemia.

1989 • 119 citations

Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study

1988 • 118 citations

Detection of immunoglobulin gene rearrangement in B lymphoid malignancies by polymerase chain reaction gene amplification

1990 • 112 citations

Pre-B cell leukemia responds poorly to treatment: a pediatric oncology group study

1984 • 112 citations

Gene rearrangements as markers of clonal variation and minimal residual disease in acute lymphoblastic leukemia.

1987 • 111 citations

Geographical distribution of acute lymphoblastic leukaemia subtypes: second report of the collaborative group study.

1993 • 110 citations

Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse [see comments]

1991 • 110 citations

Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues

1989 • 109 citations

Adult acute lymphoblastic leukemia phenotypes defined by monoclonal antibodies

1985 • 109 citations

Consistent involvement of the bcr gene by 9;22 breakpoints in pediatric acute leukemias

1991 • 107 citations

Complete exon-intron organization of the human leukocyte common antigen (CD45) gene.

1988 • 107 citations

Subpopulations of Normal and Leukemic Human Thymocytes: An Analysis With the Use of Monoclonal Antibodies<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 107 citations

The mechanism of V(D)J recombination: A balance of diversity, specificity, and stability

1992 • 106 citations

Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia

1989 • 106 citations

Detection of minimal residual disease in T-cell acute lymphoblastic leukemia using polymerase chain reaction predicts impending relapse

1991 • 106 citations

Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia.

1988 • 105 citations

Cytogenetic studies on Burkitt's lymphoma-leukemia

1982 • 103 citations

[Hematology and blood transfusion].

1982 • 102 citations

Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study.

1990 • 100 citations

The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

1990 • 99 citations

Correlation of CD2 expression with PML gene breakpoints in patients with acute promyelocytic leukemia [see comments]

1992 • 99 citations

Stages of T-cell receptor protein expression in T-cell acute lymphoblastic leukemia

1991 • 98 citations

Immunoglobulin gene rearrangement in acute myelogenous leukemia.

1984 • 95 citations

Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

1990 • 94 citations

Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood

1990 • 92 citations

Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.

1990 • 90 citations

Unusual immunophenotypes in acute leukaemias: incidence and clinical correlations

1989 • 89 citations

Microgranular variant of acute promyelocytic leukemia in children.

1992 • 88 citations

Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features [see comments]

1992 • 85 citations

T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia.

1987 • 84 citations

Immunoglobulin gene rearrangements in remission bone marrow specimens from patients with acute lymphoblastic leukemia

1986 • 81 citations

In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency

1992 • 80 citations

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.

1991 • 79 citations

Sequential high-dose ara-C and asparaginase in the therapy of previously treated and untreated patients with acute leukemia.

1985 • 79 citations

Acute lymphoblastic leukaemia (ALL) associated antigen—I. Expression in different haematopoietic malignancies

1978 • 79 citations

Evidence for origin of certain childhood acute lymphoblastic leukemias and lymphomas in thymus-derived lymphocytes

1975 • 77 citations

Prognostic importance of the pre-B-cell immunophenotype and other presenting features in B-lineage childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study

1989 • 77 citations

Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.

1990 • 76 citations

Glucocorticoid receptors in childhood acute lymphocytic leukemia.

1982 • 75 citations

Clinical significance of the presence of myeloid associated antigens in acute lymphoblastic leukaemia

1990 • 74 citations

Isolation and molecular characterization of the human CD34 gene

1992 • 72 citations

Expression of lymphoid-associated cell surface antigens by childhood acute myeloid leukemia cells lacks prognostic significance

1992 • 71 citations

Expression of myeloid-associated and lymphoid-associated cell-surface antigens in acute myeloid leukemia of childhood: a Pediatric Oncology Group study.

1992 • 71 citations

Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein.

1989 • 71 citations

Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia

1993 • 69 citations

14q32 translocations are associated with mixed-lineage expression in childhood acute leukemia

1990 • 68 citations

Modified LSA2-L2 treatment in 53 children with E-rosette-positive T- cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study)

1982 • 66 citations

The detection of residual acute lymphoblastic leukemia cells with immunologic methods and polymerase chain reaction: a comparative study.

1990 • 66 citations

Mixed-lineage leukemia revisited: acute lymphocytic leukemia with myeloperoxidase-positive blasts by electron microscopy [see comments]

1990 • 65 citations

An analysis of clinical and laboratory features of acute lymphocytic leukemias with emphasis on 35 children with pre-B leukemia

1981 • 65 citations

Cellular drug resistance profiles that might explain the prognostic value of immunophenotype and age in childhood acute lymphoblastic leukemia.

1993 • 64 citations

Glucocorticoid receptors in immunological subtypes of childhood acute lymphocytic leukemia cells: a Pediatric Oncology Group Study.

1985 • 64 citations

Interphase cytogenetic analysis detects minimal residual disease in a case of acute lymphoblastic leukemia and resolves the question of origin of relapse after allogeneic bone marrow transplantation

1991 • 63 citations

Adult acute lymphoblastic leukemia: results of the Iowa HOP-L protocol.

1989 • 63 citations

Myeloid surface antigen expression in adult acute lymphoblastic leukemia.

1990 • 62 citations

Antigen receptor genes as molecular markers of lymphoid neoplasms.

1987 • 60 citations

Rearrangement of immunoglobulin and T cell antigen receptor genes in acute myeloid leukemia with lymphoid-associated markers.

1987 • 60 citations

Myeloid surface antigen-positive acute lymphoblastic leukemia (My+ ALL): immunophenotypic, ultrastructural, cytogenetic, and molecular characteristics.

1989 • 60 citations

Solitary expression of CD7 among T-cell antigens in acute myeloid leukemia: identification of a group of patients with similar T-cell receptor beta and delta rearrangements and course of disease suggestive of poor prognosis

1991 • 60 citations

Southwest Oncology Group experience with immunological phenotyping in acute lymphocytic leukemia of childhood.

1981 • 60 citations

The relationship of blast cell glucocorticoid receptor levels to response to single-agent steroid trial and remission response in children with acute lymphoblastic leukemia

1984 • 59 citations

Structure, Function, And Genetics Of Human B Cell-Associated Surface Molecules

1989 • 58 citations

Pretreatment cytokinetic studies in 94 children with acute leukemia. Relationship to other variables at diagnosis and to outcome of standard treatment

1977 • 58 citations

Sensitive detection of clonal antigen receptor gene rearrangements for the diagnosis and monitoring of lymphoid neoplasms by a polymerase chain reaction-mediated ribonuclease protection assay

1991 • 57 citations

Cytogenetic features and serum lactic dehydrogenase level predict a poor treatment outcome for children with pre-B-cell leukemia

1986 • 55 citations

Chronic myeloid leukemia with permanent disappearance of the Ph1 chromosome and development of new clonal subpopulations

1979 • 54 citations

Proliferation of normal and malignant human immature lymphoid cells

1988 • 53 citations

Significance of aberrant immunophenotypes in childhood acute lymphoid leukemia

1991 • 52 citations

The immunophenotype in infant acute lymphoblastic leukaemia: correlation with clinical outcome. An Italian multicentre study (AIEOP)

1992 • 50 citations

Pediatric Oncology Group Utilization of Immunologic Markers in the Designation of Acute Lymphocytic Leukemia Subgroups: Influence on Treatment Responsea

1984 • 48 citations

Unfavorable presenting clinical and laboratory features are associated with calla-negative non-t, non-b lymphoblastic leukemia in children

1986 • 48 citations

Acute lymphoid leukemia in adolescents: clinical and biologic features predict a poor prognosis--a Pediatric Oncology Group Study.

1988 • 48 citations

Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.

1974 • 47 citations

‘MACHO’ chemotherapy for stage IV B cell lymphoma and B cell acute lymphoblastic leukaemia of childhood

1990 • 46 citations

Flow cytometric detection of rare normal human marrow cells with immunophenotypes characteristic of acute lymphoblastic leukemia cells.

1992 • 45 citations

Kappa-chain gene rearrangement in an apparent T-lineage lymphoma.

1986 • 45 citations

Detection of Minimal Residual Acute Lymphoblastic Leukemia by Immunological Marker Analysis: Possibilities and Limitations

1986 • 45 citations

Cytogenetic Abnormalities in Childhood Acute Lymphoblastic Leukemia Correlates with Clinical Features and Treatment Outcome

1992 • 45 citations

Infant leukemia in Japan: Clinical and biological analysis of 48 cases

1991 • 45 citations

Minimal residual disease in acute lymphoblastic leukemia detected by immune selection and gene rearrangement analysis.

1989 • 43 citations

Cytosine arabinoside/cyclophosphamide pulses during continuation therapy for childhood acute lymphoblastic leukemia. Potential selective effect in T-cell leukemia

1987 • 43 citations

Lack of CD24 antigen expression in B-lineage acute lymphoblastic leukemia is associated with intrinsic radiation resistance of primary clonogenic blasts

1993 • 42 citations

Clinical significance of low levels of myeloperoxidase positivity in childhood acute nonlymphoblastic leukemia

1987 • 41 citations

High risk lymphoblastic leukemia in children: Prognostic factors and management

1987 • 40 citations

Clinical and biological heterogeneity of childhood B cell acute lymphocytic leukemia: implications for clinical trials.

1990 • 40 citations

Rearrangement of kappa-chain and T-cell receptor beta-chain genes in malignant lymphomas of "T-cell" phenotype.

1987 • 40 citations

The role of cyclins in the maturation of Patella vulgata oocytes.

1991 • 39 citations

Immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen-positive childhood T-cell leukemia A pediatric oncology group study

1987 • 38 citations

Carbonic Anhydrase: Zinc and the Mechanism of Catalysisa

1984 • 35 citations

Clinical and biologic features of childhood T-cell leukemia with the t(11;14)

1991 • 34 citations

Lineage specificity of rearrangement and expression of genes encoding the T cell receptor-T3 complex and immunoglobulin heavy chain in leukemia.

1987 • 33 citations

Rearrangement of the T cell receptor gamma-chain gene in childhood acute lymphoblastic leukemia

1987 • 33 citations

Acute Lymphoid Leukemia

1983 • 33 citations

Presenting features and treatment outcome of adolescents with acute lymphoblastic leukemia.

1990 • 30 citations

Current results of studies of immunophenotype-, age- and leukocyte-based therapy for children with acute lymphoblastic leukemia

1992 • 30 citations

T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.

1987 • 29 citations

Expression of activation antigens CD38 and CD71 is not clinically important in childhood acute lymphoblastic leukemia.

1993 • 28 citations

Childhood leukemia-lymphoma. Heterogeneity of phenotypes and prognoses.

1979 • 28 citations

Morphologic and cytochemical characterization of adult lymphoid leukemias which express myeloid antigen.

1988 • 27 citations

Synergistic potentiation of in vivo antitumor activity of anti-human T-leukemia immunotoxins by recombinant alpha-interferon and daunorubicin.

1990 • 26 citations

Further characterization of a fodrin-containing transmembrane complex from mouse T-lymphoma cells

1987 • 25 citations

Clinicopathologic aspects of E rosette negative T cell acute lymphocytic leukemia: a Pediatric Oncology Group study.

1986 • 23 citations

Expression of the CD2 molecule on human B lymphoid progenitors

1992 • 23 citations

Immunomagnetic bone marrow purging of common acute lymphoblastic leukemia cells: suitability of BioMag particles.

1991 • 18 citations

Inzidenz, klinische Merkmale und prognostische Bedeutung immunologischer Subtypen der akuten lymphoblastischen Leukämie (ALL) im Kindesalter: Erfahrungen der Therapiestudien ALL-BFM 83 und 86

1990 • 18 citations

Expression of haematopoietic progenitor cell-associated antigen BI-3C5/CD34 in leukaemia

1989 • 17 citations

Serum CD4, CD8, and interleukin-2 receptor levels in childhood acute myeloid leukemia.

1991 • 17 citations

Acute Myeloid Leukemia Expressing T-Cell Antigens: Clinico-Hematological Report on Six Cases

1990 • 15 citations

Prognostic significance of the acute lymphoblastic leukemia (All) cell-associated antigen in children with null-cell all

1980 • 14 citations

The human leucocyte-common (LC) molecule: Dissection of leukaemias using monoclonal antibodies directed against framework and restricted antigenic determinants

1985 • 12 citations

Phagocytic activity and expression of myeloid‐associated cell surface antigens by blast cells in acute lymphoblastic leukemia

1986 • 11 citations

Kappa Light Chain Gene Rearrangement in T-Cell Acute Lymphoblastic Leukemia

1990 • 11 citations

Late Intensification Therapy in Adult Acute Lymphoid Leukemia The Southeastern Cancer Study Group Experience

1992 • 7 citations

The leukemias of childhood.

1987 • 4 citations

CD2+CD19+Biphenotypic Acute Lymphoblastic Leukaemia: A Report of Three Cases and a Review of the Literature

1992 • 2 citations

Deleted Work

1955 • 0 citations

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