Strategies for Inhibition of Complement Activation in the Treatment of Neurodegenerative Diseases

Arzneimittelforschung

2005 • 8,820 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Two distinct classes of carbohydrate-recognition domains in animal lectins.

1988 • 1,259 citations

Autoimmune Response to Acetylcholine Receptor

1973 • 1,019 citations

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

1993 • 1,009 citations

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

1990 • 989 citations

Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus

1990 • 979 citations

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1985 • 881 citations

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

Complement activation by beta-amyloid in Alzheimer disease.

1992 • 804 citations

Arthritis and Allied Conditions: A Textbook of Rheumatology.

1991 • 775 citations

Macrophages and microglia in the nervous system

1988 • 742 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

The chemotactic receptor for human C5a anaphylatoxin

1991 • 660 citations

Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease.

1992 • 646 citations

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 • 646 citations

Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency.

1984 • 636 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains

1996 • 603 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

1992 • 531 citations

Complement Deficiency States and Infection

1984 • 527 citations

The Classical Complement Pathway: Activation and Regulation of the First Complement Component

1985 • 514 citations

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.

1995 • 496 citations

The Proteolytic Activation Systems of Complement

1981 • 479 citations

The CD19/CR2/TAPA-1 Complex of B Lymphocytes: Linking Natural to Acquired Immunity

1995 • 469 citations

Inflammatory oedema induced by synergism between calcitonin gene‐related peptide (CGRP) and mediators of increased vascular permeability

1985 • 445 citations

Inflammation and Alzheimer's disease pathogenesis

1996 • 444 citations

Myasthenia Gravis: Passive Transfer from Man to Mouse

1975 • 430 citations

Myasthenia Gravis

1977 • 428 citations

The toxicity in vitro of β-amyloid protein

1995 • 427 citations

Immunoglobulins and complement factors in senile plaques

1982 • 427 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

1994 • 418 citations

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980 • 409 citations

Activation of the classical complement pathway in brain tissue of Alzheimer patients

1989 • 385 citations

Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement.

1996 • 378 citations

Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.

1995 • 367 citations

Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids.

1987 • 340 citations

Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5.

1996 • 336 citations

COMPLEMENT DEFICIENCY STATES

1978 • 334 citations

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

1990 • 334 citations

Neurogenic Amplification of Immune Complex Inflammation

1996 • 334 citations

Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis: ultrastructural and light microscopic localization and electrophysiologic correlations.

1977 • 323 citations

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

1994 • 321 citations

Inflammatory mechanisms in Alzheimer's disease: implications for therapy

1994 • 321 citations

The ependyma: A protective barrier between brain and cerebrospinal fluid

1995 • 308 citations

Serum Proteins Bypass the Blood-Brain Fluid Barriers for Extracellular Entry to the Central Nervous System

1993 • 304 citations

New synthetic inhibitors of C1r̄, C1 esterase, thrombin, plasmin, kallikrein and trypsin

1981 • 299 citations

The alternative pathway of complement

1984 • 294 citations

Complement activation in amyloid plaques in Alzheimer’s dementia

1988 • 289 citations

Type 1 astrocytes and oligodendrocyte‐type 2 astrocyte glial progenitors migrate toward distinct molecules

1990 • 286 citations

Chronic relapsing experimental allergic encephalomyelitis: An experimental model of multiple sclerosis

1977 • 282 citations

EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS AND MYASTHENIA GRAVIS: BIOCHEMICAL AND IMMUNOCHEMICAL ASPECTS*

1976 • 275 citations

Microglia in human disease, with an emphasis on acquired immune deficiency syndrome.

1991 • 273 citations

Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor

1996 • 264 citations

Myasthenic Immunoglobulin Accelerates Acetylcholine Receptor Degradation

1977 • 260 citations

A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo.

1984 • 257 citations

THE ROLE OF ANTI-INFLAMMATORY DRUGS IN THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE

1996 • 256 citations

Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a.

1978 • 253 citations

Recovery of human neutrophils from complement attack: removal of the membrane attack complex by endocytosis and exocytosis.

1987 • 251 citations

Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung.

1995 • 250 citations

Changes in Serum Complement Activity in Patients with Myasthenia Gravis.

1960 • 247 citations

International business communication

1992 • 244 citations

Complement and cytokine gene expression in cultured microglia derived from postmortem human brains

1995 • 243 citations

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

1989 • 243 citations

Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines.

1995 • 243 citations

Pathology of the Guillain-Barr� syndrome

1981 • 242 citations

Role of complement in the pathogenesis of experimental autoimmune myasthenia gravis.

1978 • 239 citations

BLOOD-BRAIN BARRIER DAMAGE IN ACUTE MULTIPLE SCLEROSIS PLAQUES

1991 • 235 citations

Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins

1992 • 222 citations

Pathological mechanisms in experimental autoimmune myasthenia gravis. II. Passive transfer of experimental autoimmune myasthenia gravis in rats with anti-acetylcholine recepotr antibodies.

1976 • 218 citations

Localization and Cell Association of C1q in Alzheimer's Disease Brain

1996 • 216 citations

Chemotaxis by a CNS macrophage, the microglia

1990 • 215 citations

Distribution of clusterin in Alzheimer brain tissue

1992 • 212 citations

Ultrastructural Localization of the Terminal and Lytic Ninth Complement Component (C9) at the Motor End-plate in Myasthenia Gravis

1980 • 210 citations

Structure, function and cellular expression of complement anaphylatoxin receptors

1995 • 207 citations

Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia

1995 • 207 citations

Myasthenia gravis induced by monoclonal antibodies to acetylcholine receptors

1980 • 201 citations

Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis.

1994 • 201 citations

Monoclonal Antibodies Recognizing a Neoantigen of Poly(C9) Detect the Human Terminal Complement Complex in Tissue and Plasma

1985 • 200 citations

Complement Biosynthesis in the Central Nervous System

1995 • 199 citations

Identification of the neuritogen for experimental allergic neuritis

1979 • 188 citations

IMMUNOCYTOCHEMICAL LOCALIZATION OF THE TERMINAL COMPLEMENT COMPLEX IN MULTIPLE SCLEROSIS

1989 • 182 citations

Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation.

1987 • 182 citations

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge.

1992 • 180 citations

Biosynthesis of Complement

1976 • 180 citations

Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning

1992 • 176 citations

Activation of Macrophages by Alzheimer β Amyloid Peptide

1994 • 175 citations

Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

1989 • 174 citations

Arthritis and Allied Conditions: A Textbook of Rheumatology

1993 • 173 citations

The immunogenesis of the multiple sclerosis plaque

1971 • 171 citations

Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death

1995 • 170 citations

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

1993 • 167 citations

Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q.

1993 • 167 citations

Cytokines in neurodegeneration and repair

1995 • 165 citations

Microglia, the first line of defence in brain pathologies.

1995 • 164 citations

Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques

1984 • 164 citations

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes.

1995 • 163 citations

Activated terminal complement in cerebrospinal fluid in Guillain-Barré syndrome and multiple sclerosis.

1986 • 163 citations

Human anaphylatoxin (C3a) from the third component of complement. Primary structure.

1975 • 161 citations

Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies.

1982 • 160 citations

SP-40,40 is a constituent of Alzheimer's amyloid

1992 • 160 citations

Activation of the First Component of Complement

1987 • 160 citations

Ependymal Reactions to Injury. A Review

1995 • 157 citations

The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation

1994 • 152 citations

Development of C5a receptor antagonists. Differential loss of functional responses.

1994 • 152 citations

S-nitrosoglutathione reversibly inhibits GAPDH by S-nitrosylation

1995 • 152 citations

Alzheimer's disease : biology, diagnosis, and therapeutics

1996 • 151 citations

C4a: the third anaphylatoxin of the human complement system.

1979 • 151 citations

Membrane signaling by complement C5b-9, the membrane attack complex

1993 • 150 citations

Clusterin (SGP‐2): A multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain

1994 • 149 citations

Complement gene expression in human brain: comparison between normal and Alzheimer disease cases

1992 • 149 citations

Activation of terminal components of complement in patients with Guillain-Barré syndrome and other demyelinating neuropathies.

1987 • 148 citations

C5a-mediated release of interleukin 6 by human monocytes

1990 • 147 citations

Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus

1991 • 142 citations

Complement C1qB and C4 mRNAs responses to lesioning in rat brain

1992 • 139 citations

Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited number of C5b-9.

1985 • 139 citations

Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells

1993 • 138 citations

Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.

1995 • 137 citations

A Model for Structure-Dependent Binding of Congo Red to Alzheimer β-Amyloid Fibrils

1998 • 132 citations

Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation

1990 • 131 citations

The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement

1977 • 129 citations

Expression of complement components of the alternative pathway by glioma cell lines.

1992 • 125 citations

Mapping of the C5a receptor signal transduction network in human neutrophils.

1994 • 124 citations

Monoclonal antibodies demonstrate protection of polymorphonuclear leukocytes against complement attack

1985 • 123 citations

Bothanti-CD11a(LFA-l) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis

1995 • 120 citations

Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells.

1993 • 117 citations

MONOCLONAL AUTOANTIBODIES TO ACETYLCHOLINE RECEPTORS: EVIDENCE FOR A DOMINANT IDIORPE AND REQUIREMENT OF COMPLEMENT FOR PATHOGENICITY*

1981 • 116 citations

Elevated levels of the complement components C3 and factor B in ventricular cerebrospinal fluid of patients with traumatic brain injury

1997 • 116 citations

Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia

1980 • 116 citations

THE ENZYMATIC NATURE OF C'1r

1968 • 116 citations

Inhibition of acute passive transfer experimental autoimmune myasthenia gravis with Fab antibody to complement C6.

1989 • 115 citations

Ultrastructural Localization of Immune Complexes (IGG and C3) at the End-Plate in Experimental Autoimmune Myasthenia Gravis

1978 • 115 citations

Cell adhesion molecules of the immunoglobulin supergene family as tissue‐specific autoantigens: induction of experimental allergic neuritis (EAN) by PO protein‐specific T cell lines

1992 • 113 citations

Activation and control of the complement system.

1986 • 111 citations

Early response of brain resident microglia to kainic acid-induced hippocampal lesions

1994 • 111 citations

Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system

1996 • 111 citations

DNA binds and activates complement via residues 14-26 of the human C1q A chain.

1992 • 110 citations

Serum and CSF immunological findings in ALS

1991 • 110 citations

Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease

1994 • 109 citations

MHC-positive, ramified macrophages in the normal and injured rat peripheral nervous system

1992 • 109 citations

Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody.

1989 • 108 citations

C5 gene influences the development of murine myasthenia gravis.

1988 • 107 citations

Localization of sites through which C-reactive protein binds and activates complement to residues 14-26 and 76-92 of the human C1q A chain.

1992 • 106 citations

An Anticomplementary Agent, K-76 Monocarboxylic Acid: Its Site and Mechanism of Inhibition of the Complement Activation Cascade

1979 • 105 citations

Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain

1991 • 104 citations

Activated complement components C3a and C4a in cerebrospinal fluid and plasma following subarachnoid hemorrhage

1989 • 103 citations

Identification and characterization of complement C3 receptors on human astrocytes.

1996 • 103 citations

Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis

1995 • 103 citations

Normal rat serum cytotoxicity against syngeneic oligodendrocytes

1989 • 102 citations

Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorphonuclear leucocytes: functional relevance and role in inflammation.

1995 • 102 citations

Tissue distribution of HRF20, a novel factor preventing the membrane attack of homologous complement, and its predominant expression on endothelial cells in vivo.

1990 • 101 citations

Postischemic treatment (2–4 h) with anti-CD11b and anti-CD18 monoclonal antibodies are neuroprotective after transient (2 h) focal cerebral ischemia in the rat

1995 • 99 citations

Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease

1990 • 99 citations

Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxinsin vivo andin vitro

1994 • 97 citations

Third component of human complement: structural analysis of the polypeptide chains of C3 and C3b

1979 • 97 citations

The inhibitory effect of rosmarinic acid on complement involves the C5 convertase

1991 • 96 citations

Anti-C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor.

1993 • 95 citations

Activation of C1r by Proteolytic Cleavage

1976 • 95 citations

Interaction of myasthenic serum globulin with the acetylcholine receptor

1975 • 90 citations

ACUTE SWELLING OF OLIGODENDROGLIA

1926 • 90 citations

Guillain‐barré syndrome

1987 • 88 citations

Enhanced expression of chemotactic receptors in multiple sclerosis lesions

1996 • 88 citations

Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease

1995 • 88 citations

Reactions of the Immune System in Chronic Degenerative Neurological Diseases

1991 • 87 citations

A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates.

1982 • 87 citations

Antibody-mediated demyelination in experimental allergic encephalomyelitis is independent of complement membrane attack complex formation

1991 • 86 citations

Antibody-independent complement activation by myelin via the classical complement pathway.

1982 • 86 citations

Multivalent Binding of Complement Protein C1q to the Amyloid β-Peptide (Aβ) Promotes the Nucleation Phase of Aβ Aggregation

1995 • 85 citations

Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding

1992 • 84 citations

Generation of diacylglycerol and ceramide during homologous complement activation.

1993 • 83 citations

Interferon‐γ activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I‐Aβ, tumor necrosis factor and complement component C3 in mouse macrophages

1989 • 83 citations

Cerebral amyloid plaques in Alzheimer’s disease but not in scrapie-affected mice are closely associated with a local inflammatory process

1991 • 81 citations

TERMINAL COMPONENT OF COMPLEMENT (C9) IN CEREBROSPINAL FLUID OF PATIENTS WITH MULTIPLE SCLEROSIS

1984 • 80 citations

Activation of the alternative pathway of complement by human peripheral nerve myelin.

1985 • 79 citations

Experimental Allergic Neuritis in the Lewis Rat

1979 • 78 citations

Nonimmune activation of the classical complement pathway.

1993 • 77 citations

Possible functions of a new genetic marker in central nervous system: The sulfated glycoprotein‐2 (SGP‐2)

1992 • 77 citations

Presence of the terminal complement complex (C5b‐9) precedes myelin degradation in immune‐mediated demyelination of the rat peripheral nervous system

1991 • 77 citations

Biologic activity of synthetic analogues of C5a anaphylatoxin.

1992 • 76 citations

Time‐dependent synergistic interactions between the vasodilator neuropeptide, calcitonin gene‐related peptide (CGRP) and mediators of inflammation

1991 • 76 citations

Receptor-independent activation of guanine nucleotide-binding regulatory proteins by terminal complement complexes.

1994 • 76 citations

Induction of C3 expression in astrocytes is regulated by cytokines and Newcastle disease virus.

1992 • 76 citations

Clusterin expression by astrocytes is influenced by transforming growth factor β1 and heterotypic cell interactions

1995 • 75 citations

Complement (C5)-derived chemotactic activity accounts for accumulation of polymorphonuclear leukocytes in cerebrospinal fluid of rabbits with pneumococcal meningitis

1984 • 73 citations

Early complement components in Alzheimer's disease brains

1995 • 73 citations

Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants

1988 • 73 citations

A high incidence of C9 deficiency among healthy blood donors in Osaka, Japan

1989 • 71 citations

Complement Deficiencies in Selected Groups of Patients with Meningococcal Disease

1989 • 71 citations

FINE STRUCTURAL ASPECTS OF DEMYELINATION IN VITRO. THE EFFECTS OF GUILLAIN-BARRÉ SERUM

1971 • 70 citations

Limited proteolysis of complement components C2 and factor B. Structural analogy and limited sequence homology

1979 • 70 citations

Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches

1996 • 70 citations

Human Serum Mannose Binding Protein (MBP): Development of an Enzyme-Linked Immunosorbent Assay (ELISA) and Determination of Levels in Serum from 1085 Normal Japanese and in Some Body Fluids

1993 • 69 citations

Association of Homozygous C4B Deficiency with Bacterial Meningitis

1989 • 68 citations

Alzheimer's disease — from molecular biology to therapy

1993 • 67 citations

Antivascular Antibodies in the Sera of Patients With Senile Dementia of the Alzheimer's Type

1987 • 67 citations

Collectins, collectin receptors and the lectin pathway of complement activation

1994 • 67 citations

Complement depletion suppresses Lewis rat experimental allergic neuritis

1987 • 67 citations

Interleukin‐1 and tumor necrosis factor‐mediated regulation of C3 gene expression in human astroglioma cells

1993 • 66 citations

The Classical Complement Pathway: Mechanism of Activation of the First Component by Antigen-Antibody Complexes (Part 1 of 3)

1982 • 65 citations

Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis

1994 • 65 citations

Complement Regulatory Molecules on Human Myelin and Glial Cells: Differential Expression Affects the Deposition of Activated Complement Proteins

1996 • 65 citations

Complement-activated oligodendroglia: A new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d

1990 • 65 citations

Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression

1996 • 64 citations

High levels of C3c in the cerebrospinal fluid from amyotrophic lateral sclerosis patients

2009 • 64 citations

Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins

1996 • 63 citations

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor

1995 • 63 citations

Ultrastructural studies of complement mediated cell death: a biological reaction model to plasma membrane injury

1994 • 62 citations

Soluble complement receptor type 1 inhibits experimental autoimmune neuritis in Lewis rats

1995 • 62 citations

Identification and synthesis of a receptor binding site of human anaphylatoxin C5a

1991 • 62 citations

The expression of CD59 in normal human nervous tissue.

1994 • 61 citations

Amino-terminal calcium-binding domain of human complement C1.hivin.s mediates the interaction of C1.hivin.r with C1q

1990 • 61 citations

Preventive Effect of Synthetic Serine Protease Inhibitor, FUT-175, on Cerebral Vasospasm in Rabbits

1992 • 61 citations

Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3

1995 • 61 citations

Role of Complement in the Aetiology of Pickʼs Disease?

1996 • 60 citations

Complement, neutrophils and oxygen radicals in myocardial-ischemia reperfusion injury

1992 • 59 citations

The action of Guillain-Barré syndrome serum on myelin

1971 • 59 citations

Evidence for activation of the terminal pathway of complement and upregulation of sulfated glycoprotein (SGP)-2 in the hypoglossal nucleus following peripheral nerve injury

1995 • 59 citations

Demyelination and neurological signs in experimental allergic encephalomyelitis

1987 • 58 citations

Increased concentration of C4d complement protein in CSF in amyotrophic lateral sclerosis.

1994 • 58 citations

Pharmacological manipulation of complement system.

1984 • 57 citations

Myocardial ischemia and reperfusion: The role of oxygen radicals in tissue injury

1989 • 57 citations

Cultured Rat Microglia Express C1q and Receptor for C1q: Implications for Amyloid Effects on Microglia

1995 • 57 citations

Nature of the active site of a subunit of the first component of human complement

1969 • 55 citations

Inhibitory effect of K-76 monocarboxylic acid, an anticomplementary agent, on the C3b inactivator system.

1981 • 55 citations

Complement-mediated neurotoxicity is regulated by homologous restriction

1995 • 54 citations

In vitro and in vivo inhibition of complement activity by a single-chain Fv fragment recognizing human C5

1995 • 53 citations

Human oligodendrocytes are not sensitive to complement. A study of CD59 expression in the human central nervous system.

1995 • 53 citations

Killing of rat glial cells by complement: Deficiency of the rat analogue of CD59 is the cause of oligodendrocyte susceptibility to lysis

1993 • 53 citations

In vitro demyelination by serum antibody from patients with guillain‐barré syndrome requires terminal complement complexes

1991 • 52 citations

Oligodendrocytes lack glycolipid anchored proteins which protect them against complement lysis. Restoration of resistance to lysis by incorporation of CD59.

1992 • 52 citations

Antibodies to Cholinergic Neurons in Alzheimer's Disease

1988 • 51 citations

Identification and characterization of the effector region within human C5a responsible for stimulation of IL-6 synthesis.

1992 • 51 citations

Clusterin levels increase during neuronal development

1993 • 51 citations

Immunological characterization of surd nerve biopsies from patients with Guillain-Barr� syndrome

1981 • 50 citations

Reversible injury of cultured rat oligodendrocytes by complement.

1989 • 50 citations

Mapping the substrate binding site of human C1r and C1s with peptide thioesters. Development of new sensitive substrates.

1981 • 50 citations

Complement potentiates the degradation of myelin proteins by plasmin: Implications for a mechanism of inflammatory demyelination

1986 • 49 citations

Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state

1994 • 49 citations

Tissue culture demyelination by normal human serum

1984 • 49 citations

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

1990 • 48 citations

Cerebrospinal fluid C9 in demyelinating disease

1986 • 48 citations

Structure-function studies in a series of carboxyl-terminal octapeptide analogs of anaphylatoxin C5a

1992 • 47 citations

Complement depletion affects demyelination and inflammation in experimental allergic neuritis

1995 • 47 citations

Enzymic activity of the second component of complement

1975 • 46 citations

Complement C5b-9 activates cytosolic phospholipase A2 in glomerular epithelial cells

1995 • 46 citations

FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a

1991 • 46 citations

Interferon-gamma regulation of C3 gene expression in human astroglioma cells

1992 • 46 citations

Expression of the complement membrane attack complex and its inhibitors in Pick disease brain

1994 • 46 citations

Isolation of Membrane Attack Complex of Complement from Myelin Membranes Treated with Serum Complement

1984 • 45 citations

Calcium binding properties of the C1 subcomponents C1q, C1r and C1s

1980 • 45 citations

Complement inhibitor C4-binding protein in amyloid deposits containing serum amyloid P in alzheimer's disease

1992 • 44 citations

The effect of FUT-175 (nafamstat mesilate) on C3a, C4a and C5a generation in vitro and inflammatory reactions in vivo

1990 • 44 citations

Activation of Complement by Myelin: Identification of C1‐Binding Proteins of Human Myelin from Central Nervous Tissue

1986 • 44 citations

Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids.

1989 • 44 citations

Hydrolysis of myelin basic protein in human myelin by terminal complement complexes.

1988 • 44 citations

Transganglionic degeneration in vibrissae innervating primary sensory neurons of the rat: A light and electron microscopic study

1986 • 44 citations

Human astrocytes express membrane cofactor protein (CD46), a regulator of complement activation

1992 • 43 citations

Production and interferon-γ-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG

1992 • 43 citations

Human Factor D̄ of the Alternative Complement Pathway: Purification and Characterization

1977 • 43 citations

Modulation of the fibrinolytic response of cultured human vascular endothelium by extracellularly generated oxygen radicals.

1992 • 42 citations

Transforming growth factor-beta 1 inhibits inflammatory cytokine-induced C3 gene expression in astrocytes.

1994 • 40 citations

Elevation of human cerebrospinal fluid clusterin concentration is associated with acute neuropathology

1993 • 40 citations

Development of C5a receptor antagonists.

1999 • 39 citations

Substituted isocoumarins as inhibitors of complement serine proteases.

1992 • 39 citations

Activation of C1

1984 • 39 citations

Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors

1996 • 39 citations

Inhibition of four human serine proteases by substituted benzamidines

1978 • 38 citations

Measurement of complement components in cerebral spinal fluid by radioimmunoassay in patients with multiple sclerosis

1980 • 36 citations

Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes

1993 • 36 citations

The relationship of the hemolytic activity of active C'1s to its TAMe esterase action: a new method of purification and assay.

1969 • 35 citations

Expression of complement C1gB and C4 mRNAs during rat brain development

1994 • 35 citations

Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes.

1993 • 35 citations

Activation of human complement serine-proteinase C1r is down-regulated by a Ca2+-dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q

1994 • 34 citations

Complement C1q Does Not Bind Monomeric β-Amyloid

1994 • 33 citations

Structure and function of collectins: humoral C-type lectins with collagenous regions.

1993 • 33 citations

Cerebral vasospasm caused by cisternal injection of polystyrene latex beads in rabbits is inhibited by a serine protease inhibitor

1994 • 32 citations

Enhanced cytotoxicity of amyloid β-peptide by a complement dependent mechanism

1994 • 31 citations

Increased concentration of C4d complement protein in the cerebrospinal fluids in progressive supranuclear palsy

2009 • 31 citations

Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures

1993 • 30 citations

Decapeptide agonists of human C5a: the relationship between conformation and neutrophil response

1995 • 30 citations

Differential regulation of C3 gene expression in human astroglioma cells by interferon-γ and interleukin-1β

1995 • 30 citations

Monoclonal antibodies to human brain acetylcholinesterase: properties and applications

1988 • 30 citations

Human antibodies to neurofibrillary tangles and astrocytes in Alzheimer's disease

1988 • 29 citations

Nonsteroidal antiinflammatory agents inhibit upregulation of CD11b, CD11c, and CD35 in neutrophils stimulated by formyl-methionine-Leucine-phenylalanine

1990 • 28 citations

Effects of K-76 Monocarboxylic Acid, an Anticomplementary Agent, on Various in vivo Immunological Reactions and on Experimental Glomerulonephritis

1984 • 28 citations

Age-related resistance to experimental autoimmune myasthenia gravis in rats.

1993 • 28 citations

Age related resistance to experimental autoimmune myasthenia gravis in rats

1991 • 26 citations

Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224‐015, an inhibitor of the interleukin‐1β converting enzyme

1995 • 26 citations

Design, Synthesis, and Evaluation of A-, C-, and D-Ring Analogs of the Fungal Metabolite K-76 as Potential Complement Inhibitors

1995 • 26 citations

The 2.2 .ANG. resolution x-ray crystal structure of the complex of trypsin inhibited by 4-chloro-3-ethoxy-7-guanidinoisocoumarin: a proposed model of the thrombin-inhibitor complex

1990 • 26 citations

Selective Complexing of Acetylcholinesterase in Brain by Intravenously Administered Monoclonal Antibody

1990 • 25 citations

The Relationship of the Hemolytic Activity of Active C′ls to Its TAMe Esterase Action: A New Method of Purification and Assay

1969 • 25 citations

The determination of the complement components C1q, C4 and C3 in serum and cerebrospinal fluid by radioimmunoassay

1985 • 25 citations

Allergic Encephalomyelitis: Effect of Complement Depletion with Cobra Venom

1971 • 24 citations

Death of intermediolateral spinal cord neurons follows selective, complement-mediated destruction of peripheral preganglionic sympathetic terminals by acetylcholinesterase antibodies

1993 • 24 citations

Expression of CD59, a regulator of the membrane attack complex of complement, on human astrocytes

1993 • 23 citations

Nature of the metal ion requirement for assembly and function of the first component of human complement.

1983 • 23 citations

Binding specificity and presynaptic action of anaphylatoxin C5a in rat brain

1989 • 22 citations

Biological Activities of C5a and C5a<sub>desAr</sub><sub>g</sub> from Hog Serum

1980 • 21 citations

Chemotactic effects of the complement-derived peptides C3a, C3ai and C5a (classical anaphylatoxin) on rabbit and guinea-pig polymorphonuclear leukocytes

1978 • 20 citations

Effect of intracerebral injection of monoclonal acetylcholinesterase antibodies on cholinergic nerve terminals in the rat central nervous system

1991 • 20 citations

The Enzymatic Nature of Human C1r̄: A Subcomponent of the First Component of Complement

1979 • 20 citations

Immunologically induced sympathectomy of preganglionic nerves by antibodies against acetylcholinesterase: Increased levels of peptides and their messenger rnas in rat adrenal chromaffin cells

1994 • 20 citations

Ultrastructural studies of complement mediated cell death: a biological reaction model to plasma membrane injury

1994 • 19 citations

Rates of thrombin acylation and deacylation upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylating agents

1995 • 18 citations

Role of complement in demyelination in vitro by multiple sclerosis serum and other neurological disease sera

1984 • 18 citations

Peripheral nerve CR1 express in situ cofactor activity for degradation of C3b

1990 • 18 citations

Conformationally biased analogs of human C5a mediate changes in vascular permeability.

1996 • 18 citations

Non-steroidal anti-inflammatory drugs: how do they work?

1987 • 17 citations

Inhibition of C1r̄, C1s̄ and generation of C1s̄ by amidino compounds

1973 • 17 citations

Psychopharmacological activity of immune complexes in rat brain is complement dependent

1987 • 17 citations

Isolation and characterization of complement receptors CR1 from human peripheral nerves

1989 • 15 citations

The behavior of oligodendroglia during demyelination in vitro.

1971 • 14 citations

Effects of antibodies against acetylcholinesterase on the expression of peptides and catecholamine synthesizing enzymes in the rat adrenal gland

1993 • 14 citations

Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion

1994 • 14 citations

Antibodies to the acetylcholine receptor in myasthenic dogs.

1979 • 13 citations

Pharmacological studies on 6-amidino-2-naphthyl(4-(4,5-dihydro-1H-imidazol-2-yl)amino) benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo.

1990 • 13 citations

Effect of EDTA and Citrate on the Functional Activity of the First Component of Complement, C1, and the C1q Subcomponent

1985 • 13 citations

Time-resolved immunofluorometric assay of complement C3: application to cerebrospinal fluid

1993 • 13 citations

Synthesis of the complement factors C₃and C₄within the central nervous system over the course of aseptic meningitis

1983 • 12 citations

Cerebrospinal fluid concentrations of the complement MAC inhibitor CD59 in multiple sclerosis and patients with other neurological disorders

1994 • 12 citations

Complement Factors and Acute Phase Reactants in the Guillain-Barré Syndrome

1982 • 12 citations

Synthesis and structure-activity study of protease inhibitors. III. Amidinophenols and their benzoil esters.

1984 • 12 citations

A biopsy case of Landry-Guillain-Barr� Syndrome

1971 • 11 citations

Synthesis and Structure-Activity Study of Protease Inhibitors. V. Chemical Modification of 6-Amidino-2-naphthyl 4-Guanidinobenzoate.

1993 • 11 citations

Catecholamine Release and Excretion in Rats with Immunologically Induced Preganglionic Sympathectomy

1994 • 9 citations

Synthetic peptide inhibitors of complement serine proteases—III. Significant increase in inhibitor potency provides further support for the functional equivalence hypothesis

1991 • 8 citations

Assembly of the C1 complex.

1993 • 8 citations

The Inactivation of Human C1 by Benzamidine and Pyridinium Sulfonylfluorides

1974 • 7 citations

The structure and function of the first component of complement: genetic engineering approach (a review).

1994 • 7 citations

Isolierung und Kristallisation der Human-Komplement-Subkomponente Clr̄ des Cl-Komplexes

1981 • 6 citations

Inhibitory Effects of a Novel Synthetic Protease Inhibitor, FUT-175, on the Paw Edema in Rats and Zymosan-induced Complement Activation in Vitro

1986 • 5 citations

Chapter 4. Emerging Opportunities in Neuroinflammatory Mechanisms of Neurodegeneration

1995 • 2 citations

[Activation and free radical formation of leukocytes in patients with acute ischemic stroke].

1994 • 2 citations

Section Review Central & Peripheral Nervous Systems: Alzheimer's disease and β-amyloid: patent activity between May 1995 and July 1996

1996 • 1 citations

Deleted Work

1955 • 0 citations