Inflammatory mechanisms in Alzheimer's disease: implications for therapy

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Lysosomotropic agents

1974 • 1,887 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1991 • 1,330 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

1989 • 856 citations

Complement activation by beta-amyloid in Alzheimer disease.

1992 • 804 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Colchicine in the Prevention and Treatment of the Amyloidosis of Familial Mediterranean Fever

1986 • 667 citations

A Double-Blind, Placebo-Controlled Multicenter Study of Tacrine for Alzheimer's Disease

1992 • 618 citations

Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta.

1990 • 604 citations

Textbook of Rheumatology.

1988 • 593 citations

Elevated circulating tumor necrosis factor levels in Alzheimer's disease

1991 • 489 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

1991 • 484 citations

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

1987 • 475 citations

The Stress Response and the Regulation of Inflammatory Disease

1992 • 469 citations

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults

1985 • 406 citations

The Amino Acid Sequence of a Major Nonimmunoglobulin Component of Some Amyloid Fibrils

1972 • 397 citations

Arthritis and Allied Conditions

1985 • 374 citations

Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord

1990 • 373 citations

<scp>D</scp>-Penicillamine Therapy in Progressive Systemic Sclerosis (Scleroderma)

1982 • 317 citations

Cytokines as modulators of the hypothalamus-pituitary-adrenal axis

1991 • 289 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1991 • 276 citations

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

1991 • 267 citations

The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes

1988 • 263 citations

IMMUNOLOGIC STUDIES OF THE MAJOR NONIMMUNOGLOBULIN PROTEIN OF AMYLOID

1973 • 236 citations

Use of short‐term efficacy/toxicity tradeoffs to select second‐line drugs in rheumatoid arthritis. A metaanalysis of published clinical trials

1992 • 232 citations

Adrenal glucocorticoids after twenty years

1970 • 209 citations

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 202 citations

STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VI. THE PHYSIOLOGICAL DISPOSITION, ANTIMALARIAL ACTIVITY, AND TOXICITY OF SEVERAL DERIVATIVES OF 4-AMINOQUINOLINE 12

1948 • 180 citations

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

1990 • 174 citations

Inhibition of lysosomal phospholipase A and phospholipase C by chloroquine and 4,4'-bis(diethylaminoethoxy) alpha, beta-diethyldiphenylethane.

1980 • 169 citations

Immunosuppressive potential of antimalarials

1983 • 158 citations

α1-Antichymotrypsin is associated solely with amyloid deposits containing the β-protein. Amyloid and cell localization of α1-antichymotrypsin

1990 • 153 citations

α1‐Antichymotrypsin as a possible biochemical marker for Alzheimer‐type dementia

1990 • 147 citations

The disordered neuronal cytoskeleton in Alzheimer's disease

1992 • 124 citations

Cognitive dysfunction associated with naproxen and ibuprofen in the elderly

1982 • 123 citations

Chloroquine Diphosphate in Rheumatoid Arthritis : A Controlled Trial

1961 • 122 citations

Glucocorticoids and hippocampal damage

1987 • 120 citations

Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.

1991 • 105 citations

Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert

1991 • 105 citations

Cytokines and inflammation

1992 • 101 citations

The participation of interleukin-6 in the pathogenesis of alzheimer's disease

1992 • 100 citations

Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease

1990 • 99 citations

Central and Peripheral Endorphins: Basic and Clinical Aspects

1986 • 89 citations

Complement activation and β-amyloid-mediated neurotoxicity in Alzheimer's disease

1992 • 81 citations

Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid

1989 • 79 citations

Colchicine effects on lysosomal enzyme induction and intracellular degradation in the cultivated macrophage.

1975 • 79 citations

Hydroxychloroquine sulfate (“Plaquenil”) in treatment of rheumatoid arthritis

1962 • 78 citations

Colchicine

1974 • 69 citations

Effect of sulphasalazine on the radiological progression of rheumatoid arthritis.

1987 • 61 citations

The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia

1990 • 61 citations

Enzyme specificity of proteinase inhibitor region in amyloid precursor protein of Alzheimer's disease: different properties compared with protease nexin I

1990 • 55 citations

Plasma and cerebrospinal fluid concentrations of indomethacin in humans

1990 • 54 citations

The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2.

1991 • 51 citations

Serum Amyloid P in Alzheimer's Disease

1991 • 51 citations

Ocular Safety of Hydroxychloroquine Sulfate (Plaquenil)

1992 • 48 citations

Cytokines and inflammatory proteins in alzheimer's disease

1992 • 47 citations

Developmental expression of α1-antichymotrypsin in brain may be related to astrogliosis

1991 • 46 citations

Complement inhibitor C4-binding protein in amyloid deposits containing serum amyloid P in alzheimer's disease

1992 • 44 citations

The role of the acute-phase protein α1-antichymotrypsin in brain dysfunction and injury

1992 • 40 citations

Distribution pattern and functional state of complement proteins and α-antichymotrypsin in cerebral β/A4 deposits in Alzheimer's disease

1992 • 39 citations

Distribution of Radioactive Colchicine in Some Organs of Normal and Tumor-bearing Mice.

1951 • 37 citations

ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE EFFECTS OF RECOMBINANT SOLUBLE COMPLEMENT RECEPTORS

1991 • 37 citations

Serological α₁‐Antichymotrypsin in Down's syndrome and Alzheimer's disease

1992 • 37 citations

PLAQUENIL IN THE TREATMENT OF LUPUS ERYTHEMATOSUS

1956 • 37 citations

Anatomic, Metabolic, Neuropsychological, and Molecular Genetic Studies of Three Pairs of Identical Twins Discordant for Dementia of the Alzheimer's Type

1991 • 37 citations

Role of Microtubuli in the Lysosomal Degradation of Endogenous and Exogenous Protein in Isolated Rat Hepatocytes

1981 • 31 citations

Monozygotic twins discordant for Alzheimer's disease

1989 • 28 citations

Hydroxychloroquine sulfate in rheumatoid arthritis: Long-term response rate and predictive parameters

1983 • 25 citations

Complements, microglial cells and amyloid fibril formation

1992 • 25 citations

Inhibition of interleukin-1 release by IX 207-887

1990 • 18 citations

Toxic and Metabolic Encephalopathies in Long-Term Care Patients

1991 • 16 citations

Combined Administration of Physcostigmine and Clonidine to Paients with Dementia of the Alzheimer Type

1989 • 13 citations

A hypothesis concerning the role of endogenous colchicine-like factors in the etiology of Alzheimer's disease

1987 • 7 citations