The alternative pathway of complement

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.

1977 • 685 citations

Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte

1980 • 645 citations

Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

1982 • 603 citations

Modulation of the alternative complement pathways by beta 1 H globulin.

1976 • 586 citations

Control of the amplification convertase of complement by the plasma protein beta1H.

1976 • 571 citations

Third component of human complement: purification from plasma and physicochemical characterization

1976 • 523 citations

Primate erythrocyte-immune complex-clearing mechanism.

1983 • 495 citations

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

1975 • 474 citations

Activation of the alternate pathway of human complements by rabbit cells.

1974 • 473 citations

Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions

1971 • 465 citations

Large scale isolation of functionally active components of the human complement system.

1981 • 446 citations

Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane

1979 • 444 citations

Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

1983 • 438 citations

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

1981 • 426 citations

ISOLATION OF ß1F-GLOBULIN FROM HUMAN SERUM AND ITS CHARACTERIZATION AS THE FIFTH COMPONENT OF COMPLEMENT

1965 • 416 citations

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

1978 • 415 citations

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980 • 409 citations

Evidence for presence of an internal thiolester bond in third component of human complement.

1980 • 368 citations

THE PROPERDIN SYSTEM AND IMMUNITY

1956 • 363 citations

Interaction between the third complement protein and cell surface macromolecules.

1977 • 345 citations

Complement C3 convertase: Cell surface restriction of β1H control and generation of restriction on neuraminidase-treated cells

1978 • 344 citations

Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.

1979 • 339 citations

Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.

1979 • 338 citations

Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes.

1982 • 335 citations

Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement.

1980 • 328 citations

C3 PROACTIVATOR CONVERTASE AND ITS MODE OF ACTION

1972 • 326 citations

Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria.

1983 • 324 citations

The covalent-binding reaction of complement component C3

1981 • 304 citations

Evidence for an Ester Linkage between the Labile Binding Site of C3b and Receptive Surfaces

1979 • 297 citations

Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity.

1982 • 296 citations

Depletion of Plasma Complement in Vivo by a Protein of Cobra Venom: Its Effect on Various Immunologic Reactions

1970 • 294 citations

Human C4-binding protein. II. Role in proteolysis of C4b by C3b-inactivator.

1978 • 285 citations

Activation of the alternative complement pathway due to resistance of zymosan-bound.

1977 • 283 citations

Complement receptor is an inhibitor of the complement cascade.

1981 • 267 citations

Human Alternative Complement Pathway: Membrane-Associated Sialic Acid Regulates the Competition between B and β1H for Cell-Bound C3b

1979 • 257 citations

THE REACTION MECHANISM OF ß1C-GLOBULIN (C'3) IN IMMUNE HEMOLYSIS

1966 • 250 citations

Capsular sialic acid prevents activation of the alternative complement pathway by type III, group B streptococci.

1982 • 210 citations

The Demonstration in Human Serum of “Conglutinogen-Activating Factor” and its Effect on the Third Component of Complement

1968 • 206 citations

Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway.

1976 • 204 citations

Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies.

1982 • 202 citations

The Alternative Pathway C3/C5 Convertase: Chemical Basis of Factor B Activation

1979 • 201 citations

Mechanism of action of factor D of the alternative complement pathway.

1978 • 191 citations

The physiological breakdown of the third component of human complement

1980 • 187 citations

Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties

1981 • 184 citations

Covalent binding and hemolytic activity of complement proteins.

1980 • 183 citations

LYSIS OF ERYTHROCYTES BY COMPLEMENT IN THE ABSENCE OF ANTIBODY

1970 • 181 citations

Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b.

1979 • 180 citations

The Alternative Pathway of Complement Activation

1976 • 180 citations

Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins

1977 • 178 citations

Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins.

1978 • 172 citations

Characterization of alkylamine-sensitive site in alpha 2-macroglobulin.

1979 • 159 citations

Properties of highly purified human properdin.

1968 • 158 citations

Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins.

1979 • 158 citations

The alternate pathway of complement activation. The role of C3 and its inactivator (KAF).

1973 • 153 citations

Mechanism of action of the C3b inactivator: Requiremen for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b′)

1977 • 152 citations

The role of C4-binding protein and {beta }1H in proteolysis of C4b and C3b

1979 • 148 citations

Polymorphism of human erythrocyte C3b/C4b receptor.

1983 • 145 citations

The influence of C3b inactivator (KAF) concentration on the ability of serum to support complement activation.

1975 • 144 citations

RELATION OF A ß1-GLYCOPROTEIN OF HUMAN SERUM TO THE COMPLEMENT SYSTEM

1960 • 142 citations

Third component of human complement: structural requirements for its function

1980 • 138 citations

Third component of human complement: appearance of a sulfhydryl group following chemical or enzymic inactivation

1980 • 137 citations

Genetic regulation of a structural polymorphism of human C3b receptor.

1983 • 135 citations

Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.

1984 • 131 citations

A new function of the activated third component of complement: binding to C5, an essential step for C5 activation.

1978 • 126 citations

PROPERDIN FACTOR D: CHARACTERIZATION OF ITS ACTIVE SITE AND ISOLATION OF THE PRECURSOR FORM

1974 • 117 citations

Inhibition of complement by a substance isolated from human erythrocytes — I

1969 • 117 citations

Properdin- and nephritic factor-dependent C3 convertases: requirement of native C3 for enzyme formation and the function of bound C3b as properdin receptor.

1975 • 115 citations

Cobra venom factor: structural homology with the third component of human complement.

1984 • 111 citations

C3 Requirements for Formation of Alternative Pathway C5 Convertase

1976 • 110 citations

C3b deposition during activation of the alternative complement pathway and the effect of deposition on the activating surface.

1983 • 108 citations

The cobra venom factor-dependent C3 convertase of human complement. A kinetic and thermodynamic analysis of a protease acting on its natural high molecular weight substrate.

1982 • 107 citations

The binding of human complement proteins C5, factor B, β1H and properdin to complement fragment C3b on zymosan

1981 • 107 citations

Properties of Highly Purified Human Properdin

1968 • 106 citations

Fourth component of human complement: studies of an amine-sensitive site comprised of a thiol component

1981 • 104 citations

Physiologic inactivation of fluid phase C3b: isolation and structural analysis of C3c, C3d,g (alpha 2D), and C3g.

1984 • 104 citations

Molecular cloning and characterization of the gene coding for human complement protein factor B.

1983 • 103 citations

Cobra venom factor: Improved method for purification and biochemical characterization

1984 • 103 citations

Activation of the alternative complement pathway: recognition of surface structures on activators by bound C3b.

1980 • 103 citations

Binding reaction between the third human complement protein and small molecules

1981 • 102 citations

A molecular concept of the properdin pathway.

1976 • 98 citations

Purification of the human complement control protein C3b inactivator

1980 • 98 citations

Role of human factor I and C3b receptor in the cleavage of surface‐bound C3bi molecules

1983 • 96 citations

The induction of macrophage spreading by factor B of the properdin system.

1979 • 96 citations

Paroxysmal nocturnal hemoglobinuria: deficiency in factor H-like functions of the abnormal erythrocytes.

1983 • 96 citations

The role of antibody in the activation of the alternative complement pathway

1983 • 95 citations

Antibody-independent activation of the alternative complement pathway by measles virus-infected cells.

1980 • 95 citations

C3 convertase of human complement: enhanced formation and stability of the enzyme generated with nickel instead of magnesium.

1982 • 94 citations

Inhibition of complement by a substance isolated from human erythrocytes—II

1969 • 92 citations

Pattern of degradation of human complement fragment, C3b

1981 • 91 citations

Binding of C3b proceeds by a transesterification reaction at the thiolester site

1982 • 88 citations

Anaphylaxis after hymenoptera stings in three patients with urticaria pigmentosa

1983 • 87 citations

MHC Class III products: an electron microscopic study of the C3 convertases of human complement.

1984 • 81 citations

The Binding of Activated C3 to Polysaccharides and Immunoglobulins

1978 • 77 citations

Structural characterization of factor I mediated cleavage of the third component of complement

1982 • 77 citations

Characterization of the interaction of human C4b-binding protein with physiological ligands.

1984 • 75 citations

Studies of the molecular mechanisms of C3b inactivation and a simplified assay of beta 1H and the C3b inactivator (C3bINA).

1979 • 75 citations

Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I

1983 • 74 citations

Mechanisms of Immune Lysis of Red Blood Cells In Vitro I. PAROXYSMAL NOCTURNAL HEMOGLOBINURIA CELLS

1973 • 74 citations

Species specificity of recognition by the alternative pathway of complement.

1985 • 74 citations

Functional properties of membrane-associated complement receptor CR1.

1983 • 74 citations

Lysis of measles virus-infected cells by the purified cytolytic alternative complement pathway and antibody.

1979 • 73 citations

Release of soluble immune complexes from immune adherence receptors on human erythrocytes is mediated by C3b inactivator independently of β1H and is accompanied by generation of C3c

1982 • 72 citations

Localization of the conglutinin binding site on the third component of human complement.

1985 • 71 citations

Hemolytic Activity of Lipoprotein-Depleted Serum and the Effect of Certain Anions on Complement

1966 • 69 citations

Characterization of the initial C3 convertase of the alternative pathway of human complement.

1984 • 68 citations

The Serine Protease Nature of the C3 and C5 Convertases of the Classical and Alternative Complement Pathways

1976 • 68 citations

Assembly of the cytolytic alternative pathway of complement from 11 isolated plasma proteins.

1978 • 66 citations

Structure of murine complement component C3. I. Nucleotide sequence of cloned complementary and genomic DNA coding for the beta chain.

1984 • 66 citations

Ultrastructure of cobra venom factor-dependent C3/C5 convertase and its zymogen, factor B of human complement.

1982 • 64 citations

Complement Lysis of Human Erythrocytes

1979 • 64 citations

The structure and function of the third component of human complement—I. The nature and extent of conformational changes accompanying C3 activation

1981 • 64 citations

Treatment of Human Complement Components C4 and C3 with Amines or Chaotropic Ions

1981 • 62 citations

Reaction Mechanisms of β1H Globulin

1978 • 59 citations

Initiation of C3 cleavage in the alternative complement pathway.

1975 • 58 citations

Lack of binding of human C3, in its native state, to C3b receptors.

1981 • 58 citations

Restriction of alternative complement pathway activation by sialosylglycolipids

1982 • 57 citations

C3 convertase of the alternative complement pathway. Demonstration of an active, stable C3b, Bb (Ni) complex.

1983 • 55 citations

Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity.

1984 • 55 citations

Activation of complement via the alternative pathway.

1983 • 54 citations

The interaction of C5 with C3b in free solution: a sufficient condition for cleavage by a fluid phase C3/C5 convertase.

1980 • 54 citations

Amino acid sequence studies of human properdin—N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with trypsin and the peptides produced by cyanogen bromide treatment

1981 • 53 citations

Studies on the sub-unit structure of human properdin

1974 • 53 citations

Requirement for human red blood cells in inactivation of C3b in immune complexes and enhancement of binding to spleen cells.

1983 • 53 citations

Induction of immune cytolysis: tumor-cell killing by complement is initiated by covalent complex of monoclonal antibody and stable C3/C5 convertase.

1981 • 52 citations

Chemical characterization of human factor B of the alternate pathway of complement activation

1977 • 51 citations

Competition for immune complexes by red cells in human blood.

1982 • 51 citations

Factor D̄ of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site

1980 • 50 citations

Complement activation by the properdin system: formation of a stoichiometric, C3 cleaving complex of properdin factor B with C3b

1977 • 49 citations

Initiation of C3 Cleavage in the Alternative Complement Pathway

1975 • 49 citations

A simple alternative pathway for hemolytic assay of human complement component C3 using methylamine-treated plasma

1983 • 48 citations

An equilibrium model of the metastable binding sites of alpha 2-macroglobulin and complement proteins C3 and C4.

1982 • 46 citations

Alternative Pathway of Complement: Nonenzymatic, Reversible Transition of Precursor to Active Properdin

1977 • 44 citations

Autosomal locus regulates inverse relationship between sialic acid content and capacity of mouse erythrocytes to activate human alternative complement pathway

1978 • 44 citations

Native and activated properdin: interconvertibility and identity of amino- and carboxy-terminal sequences.

1980 • 44 citations

The separation of functionally distinct forms of the third component of human complement (C3)

1981 • 43 citations

Activation of the Complement System

1973 • 42 citations

THE BUDD‐CHIARI SYNDROME AND PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA

1981 • 40 citations

Genetic defects of complement in man

1978 • 40 citations

Activation of the alternative complement pathway of guinea-gip by liposomes incorporated with trinitrophenylated phosphatidylethanolamine.

1982 • 39 citations

Residual hemolytic and proteolytic activity expressed by Bb after decay-dissociation of C3b,Bb.

1984 • 36 citations

Activation of the fifth and sixth components of the human complement system: C6-dependent cleavage of C5 in acid and the formation of a bimolecular lytic complex, C5b,6a.

1983 • 33 citations

Species-specific inhibition by gycophorin of complement activation via the alternative pathway

1983 • 33 citations

Genetic Defects of Complement in Man

1979 • 31 citations

Synthesis of macrocyclic peptide thiolactones as models of the metastable binding sites of .alpha.2-macroglobulin and complement protein C3b

1981 • 30 citations

The Immune Adherence Receptor: Dissociation Between the Expression of Erythrocyte and Mononuclear Cell C3b Receptors

1975 • 29 citations

Mapping of the properdin-binding site in the third component of complement

1984 • 28 citations

Isolation of rabbit C3, Factor B, and Factor H and comparison of their properties with those of the human analog.

1985 • 28 citations

Paroxysmal Nocturnal Haemoglobinuria in Aplastic Anaemia

1978 • 27 citations

The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway.

1981 • 25 citations

The influence ofpH on in-vitro hæmolysis in nocturnal hæmoglobinuria

1943 • 25 citations

Properdin is a trimer

1982 • 25 citations

Partial amino acid sequence of human factor D:homology with serine proteases.

1980 • 23 citations

Amino acid sequence of human factor D of the complement system

1984 • 22 citations

Surface-dependent modulation by H of C5 cleavage by the cell-bound alternative pathway C5 convertase of human complement.

1983 • 22 citations

C3 modified at the thiolester site: Acquisition of reactivity with cellular C3b receptors

1981 • 22 citations

Structural requirements of rabbit IgG F(ab')2 fragment for activation of the complement system through the alternative pathway—I. Disulfide bonds

1981 • 19 citations

Chemical characterization of cyanogen bromide fragments from the β‐chain of human complement factor C3

1984 • 19 citations

Lysis of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes by Acid-Activated Serum

1983 • 18 citations

Extraction of Complement Inhibitory Factors from the Erythrocytes of Non-Human Species

1973 • 16 citations

T‐lymphocytes escape membrane defect in paroxysmal nocturnal haemoglobinuria

1983 • 15 citations

Membrane sialoglycolipids regulate the activation of alternative complement pathway by liposomes containing trinitrophenylaminocaproyldipalmitoylphosphatidylethaolamine.

1983 • 13 citations

Release of C3c from bound C3bi by C3b inactivator

1982 • 12 citations

ヒト,プロパージンのアミノ酸配列トリプシンでの限定たんぱく質分解により生成した分画や,臭化シアンにより生成されたペプチドの配列やN末端分析

1981 • 11 citations

On the lysis of paroxysmal nocturnal hemoglobinuria erythrocytes by complement: Dual role of C3b

1982 • 9 citations

The C3b inactivator is a serine proteinase

1982 • 8 citations

ChemInform Abstract: SYNTHESIS OF MACROCYCLIC PEPTIDE THIOLACTONES AS MODELS OF THE METASTABLE BINDING SITES OF α2‐MACROGLOBULIN AND COMPLEMENT PROTEIN C3B

1982 • 4 citations

Ultrastructural studies of the human complement components C3 and factor B and of cobra venom factor (CVF)

1982 • 2 citations

Mechanism of enhanced complement-dependent cytotoxicity of papain-treated lymphocytes: evidence for increased stability of classical pathway C3 convertase.

1982 • 2 citations

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