The Met-HGF/SF autocrine signaling mechanism is involved in sarcomagenesis

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

p53 function and dysfunction

1992 • 1,918 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats

1984 • 1,153 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

1991 • 698 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure.

1988 • 657 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

Purification and subunit structure of hepatocyte growth factor from rat platelets

1987 • 557 citations

Mechanism of met oncogene activation

1986 • 551 citations

Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice

1993 • 537 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

1991 • 491 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

1989 • 455 citations

Hepatocyte growth factor receptor and the c-met oncogene Bottaro DP, Rubin JS, Faletto DL, Chan AM-L, Kmiecik TE, Vande Woude GF, Aaronson SA. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991;251:802?804

1991 • 434 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

1993 • 373 citations

An epithelial scatter factor released by embryo fibroblasts

1985 • 368 citations

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

1994 • 363 citations

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)

1987 • 357 citations

Frequent amplification of the c-met gene in scirrhous type stomach cancer

1992 • 335 citations

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

1992 • 327 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Structure and function of hepatocyte growth factor

1991 • 307 citations

The receptor encoded by the human C‐MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors

1991 • 291 citations

The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

1991 • 259 citations

Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells

1991 • 259 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent MyoD expression in presumptive mesoderm of X. laevis

1991 • 248 citations

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

1988 • 242 citations

Hepatocyte growth factor--scatter factor: mitogen, motogen, and met.

1991 • 234 citations

Ductal morphogenesis in the mouse mammary gland: Evidence supporting a role for epidermal growth factor

1988 • 232 citations

Biosynthesis of the protein encoded by the c-met proto-oncogene.

1989 • 220 citations

The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

1994 • 215 citations

Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.

1992 • 211 citations

Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger

1993 • 206 citations

Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes.

1991 • 202 citations

Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase.

1993 • 191 citations

Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

1988 • 183 citations

c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase.

1991 • 170 citations

Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid

1994 • 168 citations

p53 and the Li-Fraumeni syndrome

1993 • 151 citations

Hepatocyte growth factor-scatter factor (HGF-SF) and the C-met receptor

1993 • 146 citations

Met expression and sarcoma tumorigenicity.

1993 • 144 citations

Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas.

1992 • 141 citations

Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: Cloning of its cDNA, purification and characterization of recombinant protein

1991 • 139 citations

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

1988 • 139 citations

Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.

1992 • 136 citations

New Method for Detecting Cellular Transforming Genes

1982 • 131 citations

Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable

1991 • 129 citations

Identification and change in the receptor for hepatocyte growth factor in rat liver after partial hepatectomy or induced hepatitis

1991 • 123 citations

Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.

1994 • 114 citations

Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells.

1993 • 111 citations

Characterization of the mouse met proto-oncogene.

1988 • 108 citations

NON-LACTOGENIC EFFECTS OF GROWTH HORMONE ON GROWTH AND INSULIN-LIKE GROWTH FACTOR-I MESSENGER RIBONUCLEIC ACID OF RAT MAMMARY GLAND

1990 • 105 citations

Effect of scatter factor on motility of epithelial cells and fibroblasts

1989 • 102 citations

Protein factors which regulate cell motility

1989 • 100 citations

Tumorigenesis induced by coexpression of human hepatocyte growth factor and the human met protooncogene leads to high levels of expression of the ligand and receptor.

1993 • 90 citations

A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells.

1992 • 90 citations

Regulation of fibroblast hepatocyte growth factor/scatter factor expression by human breast carcinoma cell lines and peptide growth factors.

1993 • 89 citations

Purified Scatter Factor Stimulates Epithelial and Vascular Endothelial Cell Migration

1990 • 86 citations

Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factor

1991 • 81 citations

Tissue Distribution of Hepatocyte Growth Factor Receptor and Its Exclusive Down-Regulation in a Regenerating Organ after Injury1

1992 • 72 citations

Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains.

1992 • 71 citations

Smooth muscle-derived factor stimulates mobility of human tumor cells.

1990 • 70 citations

Integument and Mammary Glands

1989 • 66 citations

The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.

1993 • 61 citations

Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts.

1986 • 61 citations

A fibroblast-derived tumor cytotoxic factor/F-TCF(hepatocyte growth factor/HGF) has multiple functions in vitro

1991 • 58 citations

Signal transduction in c-met mediated motogenesis.

1993 • 50 citations

Evidence for non-covalent clusters of the c-met proto-oncogene product.

1992 • 48 citations

Morphology and Development of the Rat Mammary Gland

1989 • 46 citations

Hepatocyte growth factor transforms immortalized mouse liver epithelial cells.

1993 • 46 citations

Scatter factor stimulates migration of vascular endothelium and capillary-like tube formation

1991 • 44 citations

Several mutant p53 proteins detected in cancer-prone families with Li-Fraumeni syndrome exhibit transdominant effects on the biochemical properties of the wild-type p53.

1993 • 44 citations

Oncogenes and metastatic progression.

1989 • 43 citations

Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development

1993 • 41 citations

Cell Motility Factors

1991 • 39 citations

Human Lung Cancer Cell Line Producing Hepatocyte Growth Factor/Scatter Factor

1992 • 29 citations

Immunological characterization of xenogenic anti-metatype antibodies

1991 • 27 citations

Oncogenes, growth factors and control of the cell cycle.

1993 • 25 citations

Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes

1992 • 23 citations

Down-regulation of scatter factor in MRC 5 fibroblasts by epithelial-derived cells: A model for scatter factor modulation

1992 • 21 citations

Selection for transformation and met protooncogene amplification in NIH 3T3 fibroblasts using tumor necrosis factor alpha.

1990 • 19 citations

Evidence for autocrine activation of a tyrosine kinase in a human gastric carcinoma cell line

1988 • 17 citations

Deleted Work

1955 • 0 citations