A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells.

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Epidermal Growth Factor

1979 • 2,964 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

Theory and Practice of Histotechnology

1973 • 1,145 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Monoclonal antibodies to proliferating cell nuclear antigen (PCNA)/cyclin as probes for proliferating cells by immunofluorescence microscopy and flow cytometry

1988 • 321 citations

Direct Interaction of a Ligand for the erb B2 Oncogene Product with the EGF Receptor and p185 ^{erb B2}

1990 • 279 citations

Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication

1986 • 250 citations

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1990 • 246 citations

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

1988 • 226 citations

Monoclonal antibodies specific for the neu oncogene product directly mediate anti-tumor effects in vivo.

1988 • 155 citations

Inhibition of c-erbB-2 oncogene expression by estrogens in human breast cancer cells.

1990 • 144 citations

c-erbB-2 oncoprotein expression in primary human tumors

1990 • 142 citations

Epidermal Growth Factor Receptor, but Not c-erbB-2, Activation Prevents Lactogenic Hormone Induction of the β-Casein Gene in Mouse Mammary Epithelial Cells

1990 • 129 citations

Cell differentiation and bypassing of genetic defects in the suppression of malignancy.

1987 • 118 citations

Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation.

1991 • 115 citations

Differentiation of cultured human breast cancer cells (AU‐565 and MCF‐7) associated with loss of cell surface HER‐2/neu antigen

1990 • 115 citations

HER-2/neu oncogene expression and DNA ploidy analysis in breast cancer.

1990 • 74 citations

Anti-receptor antibodies reverse the phenotype of cells transformed by two interacting proto-oncogene encoded receptor proteins.

1990 • 34 citations

C-erbB-2 protein and neuroendocrine expression in breast carcinomas.

1991 • 17 citations

Immunohistochemical study of beta- and kappa-casein in the human breast and breast carcinomas, using monoclonal antibodies.

1989 • 11 citations