Selection for transformation and met protooncogene amplification in NIH 3T3 fibroblasts using tumor necrosis factor alpha.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

Gene amplification in cultured animal cells

1984 • 639 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Cellular Transforming Genes

1982 • 622 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

1984 • 435 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.

1988 • 251 citations

Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer

1990 • 233 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

Serum-free in vitro bioassay for the detection of tumor necrosis factor

1986 • 195 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

1988 • 183 citations

Isolation of lymphoma cell variants resistant to killing by glucocorticoids

1974 • 176 citations

Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues.

1988 • 134 citations

Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells

1974 • 133 citations

Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells.

1988 • 133 citations

Mutants of cultured chinese hamster cells deficient in adenine phosphoribosyl transferase

1974 • 128 citations

Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo.

1988 • 127 citations

Expression pattern of the neu (NGL) gene-encoded growth factor receptor protein (p185neu) in normal and transformed epithelial tissues of the digestive tract.

1989 • 112 citations

Characterization of the mouse met proto-oncogene.

1988 • 108 citations

Characterization of human transforming genes from chemically transformed, teratocarcinoma, and pancreatic carcinoma cell lines.

1984 • 105 citations

Nonrandom chromosome alterations in human malignant mesothelioma.

1988 • 103 citations

Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.

1989 • 101 citations

Effects of growth factors on the antiproliferative activity of tumor necrosis factors.

1987 • 96 citations

Hamster cells with increased rates of DNA amplification, a new phenotype

1987 • 83 citations

Modulation of the growth of transformed cells by human tumor necrosis factor-alpha and interferon-gamma.

1987 • 71 citations

Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts.

1986 • 61 citations