Requirement for Ca²⁺signaling in the mechanism of thrombin-induced increase in endothelial permeability

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivo

1999 • 659 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Spontaneous transformation and immortalization of human endothelial cells

1990 • 428 citations

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

1992 • 424 citations

Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis.

1996 • 372 citations

Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

1996 • 309 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

1998 • 238 citations

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.

1994 • 228 citations

Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces.

1996 • 206 citations

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60^src

1999 • 157 citations

Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2

2000 • 146 citations

Store-operated calcium entry promotes shape change in pulmonary endothelial cells expressing Trp1

1998 • 135 citations

Functional Characterization of the Spontaneously Transformed Human Umbilical Vein Endothelial Cell Line ECV304: Use in anin VitroModel of Angiogenesis

1996 • 115 citations

Thrombin receptor activating peptides induce Ca²⁺ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet‐derived growth factor mRNA expression in cultured endothelium

1993 • 114 citations

G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

2000 • 95 citations

Segmental regulation of pulmonary vascular permeability by store-operated Ca²⁺entry

1999 • 91 citations

Calcium channel blockers nifedipine and diltiazem inhibit Ca2+ release from intracellular stores in neutrophils.

1992 • 78 citations

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.

1993 • 75 citations

Calcium dependence of the thrombin-induced increase in endothelial albumin permeability

1989 • 72 citations

Cell-cell contacts in the human cell line ECV304 exhibit both endothelial and epithelial characteristics

1999 • 71 citations

Time course of thrombin-induced increase in endothelial permeability: relationship to Ca2+i and inositol polyphosphates

1992 • 66 citations

Capacitative Calcium Entry

1998 • 50 citations

Time course of recovery of endothelial cell surface thrombin receptor (PAR-1) expression

1999 • 50 citations

Site-specific thrombin receptor antibodies inhibit Ca²⁺ signaling and increased endothelial permeability

1997 • 41 citations

Propagation of electromagnetic waves of crossroads with a reflector inside a tunnel

1989 • 36 citations

Histamine alters cadherin-mediated sites of endothelial adhesion

1999 • 32 citations

Cytosolic Ca2+ and adenylyl cyclase responses in phenotypically distinct pulmonary endothelial cells

1997 • 32 citations