Choroid Plexus in the Central Nervous System: Biology and Physiopathology

Retinoic Acid Embryopathy

1985 • 1,921 citations

The Leptin Receptor

1997 • 1,300 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Leptin regulates proinflammatory immune responses

1998 • 1,161 citations

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

1997 • 705 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice

1998 • 579 citations

Physiology of the CSF and Blood-Brain Barriers

1996 • 569 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

1994 • 397 citations

The Intracerebral Movement of Proteins Injected into Blood and Cerebrospinal Fluid of Mice

1968 • 350 citations

Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin

1999 • 330 citations

Cellular Pattern of Insulin-Like Growth Factor-I (IGF-I) and Type I IGF Receptor Gene Expression in Early Organogenesis: Comparison with IGF-II Gene Expression

1990 • 320 citations

Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations

1999 • 313 citations

Localization of the Organic Anion Transporting Polypeptide 2 (Oatp2) in Capillary Endothelium and Choroid Plexus Epithelium of Rat Brain

1999 • 300 citations

Slit2-Mediated Chemorepulsion and Collapse of Developing Forebrain Axons

1999 • 280 citations

Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.

1998 • 262 citations

Chemorepulsion of Neuronal Migration by Slit2 in the Developing Mammalian Forebrain

1999 • 250 citations

Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat

1999 • 244 citations

A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat

1990 • 239 citations

Fate of Cerebrospinal Fluid‐Borne Amyloid β‐Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral Arteries

1996 • 223 citations

The Bacterial Endotoxin Lipopolysaccharide has the Ability to Target the Brain in Upregulating Its Membrane CD14 Receptor Within Specific Cellular Populations

1998 • 215 citations

Quantitative autoradiographic localization of [¹²⁵I]insulin‐like growth factor I, [¹²⁵I]insulin‐like growth factor II, and [¹²⁵I]insulin receptor binding sites in developing and adult rat brain

1993 • 207 citations

Interaction of Apolipoprotein J-Amyloid β-Peptide Complex with Low Density Lipoprotein Receptor-related Protein-2/Megalin

1997 • 197 citations

Developmental gene expression and tissue distribution of the CHIP28 water-channel protein.

1993 • 185 citations

The Evolution of Gene Expression, Structure and Function of Transthyretin

1997 • 183 citations

Demonstration of a Coupled Metabolism–Efflux Process at the Choroid Plexus as a Mechanism of Brain Protection Toward Xenobiotics

1999 • 180 citations

BARRIER MECHANISMS IN THE BRAIN, II. IMMATURE BRAIN

1999 • 164 citations

The development of a blood‐brain barrier mechanism in foetal sheep

1974 • 158 citations

Morphological alterations of the choroid plexus in late-onset Alzheimer’s disease

2000 • 153 citations

Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat

1996 • 144 citations

The choroid plexus epithelium is the site of the organic anion transport protein in the brain

1997 • 140 citations

Immune regulation within the central nervous system

1998 • 126 citations

Interaction ofNeisseria meningitidiswith the Components of the Blood‐Brain Barrier Correlates with an Increased Expression of PilC

1997 • 121 citations

HIV Infection of Human Choroid Plexus

1995 • 115 citations

Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain.

1992 • 114 citations

Low Levels of Transthyretin in the CSF of Depressed Patients

1999 • 108 citations

Distinct Sites of Insulin-Like Growth Factor (IGF)-II Expression and Localization in Lesioned Rat Brain: Possible Roles of IGF Binding Proteins (IGFBPs) in the Mediation of IGF-II Activity**This work was supported by grants (to A.L. and M.B.) from The Wellcome Trust and The International Spinal Research Trust.

1999 • 107 citations

Origin, nature, and some functional considerations of intraventricular macrophages, with special reference to the epiplexus cells

1998 • 107 citations

C10 Is a Novel Chemokine Expressed in Experimental Inflammatory Demyelinating Disorders that Promotes Recruitment of Macrophages to the Central Nervous System

1999 • 107 citations

Human immunodeficiency virus type 1 infection of the brain

1993 • 106 citations

Neuronal, glial, and epithelial localization of ?-aminobutyric acid transporter 2, a high-affinity ?-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures

1999 • 101 citations

The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo

1997 • 97 citations

HLA-DR-positive dendritic cells of the normal human choroid plexus: A potential reservoir of HIV in the central nervous system

1998 • 91 citations

Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system

1997 • 88 citations

Stromal macrophages of the choroid plexus situated at an interface between the brain and peripheral immune system constitutively express major histocompatibility class II antigens

1992 • 88 citations

Signals that go with the flow

1999 • 87 citations

Influence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesis

1996 • 86 citations

Ultrastructural localization of adhesion molecules in the healthy

1999 • 84 citations

Mechanism of Organic Anion Transport across the Apical Membrane of Choroid Plexus

1999 • 80 citations

Chronic overexpression of proinflammatory cytokines and histopathology in the brains of rats infected withTrypanosoma brucei

1999 • 80 citations

Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.

1999 • 76 citations

Immunological function of the blood-cerebrospinal fluid barrier.

1989 • 76 citations

Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretin-null mice

1997 • 72 citations

Monocyte-derived IL-10-secreting dendritic cells in choroid plexus epithelium

2000 • 70 citations

Curly Fiber and Tangle-like Inclusions in the Ependyma and Choroid Plexus–A Pathogenetic Relationship with the Cortical Alzheimer-type Changes?

1998 • 67 citations

Detection of human T-lymphotropic virus type I p40^taxprotein in cerebrospinal fluid cells from patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis

1999 • 65 citations

A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor

1999 • 64 citations

An experimental and ultrastructural study on the development of the avian choroid plexus

1989 • 62 citations

Expression of the β‐subunit isoforms of the Na, K‐ATpase in rat embryo tissues, inner ear and choroid plexus

1994 • 62 citations

In Vitro Evidence That β-Amyloid Peptide 1–40 Diffuses Across the Blood–Brain Barrier and Affects Its Permeability

2000 • 61 citations

Mitochondrial content of choroid plexus epithelium

1997 • 58 citations

Cerebrospinal Fluid Mononuclear Cell Counts Influence CSF HIV-1 RNA Levels

1998 • 55 citations

Functional characterization of choroid plexus epithelial cells in primary culture.

1997 • 55 citations

Capacity to form choroid plexus-like cells in vitro is restricted to specific regions of the mouse neural ectoderm

1993 • 52 citations

The transport of the anti‐HIV drug, 2′,3′‐didehydro‐3′‐deoxythymidine (D4T), across the blood‐brain and blood‐cerebrospinal fluid barriers

1998 • 50 citations

Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain

1992 • 46 citations

Inhibition by Lead of Production and Secretion of Transthyretin in the Choroid Plexus: Its Relation to Thyroxine Transport at Blood–CSF Barrier

1999 • 44 citations

Distinct Sites of Insulin-Like Growth Factor (IGF)-II Expression and Localization in Lesioned Rat Brain: Possible Roles of IGF Binding Proteins (IGFBPs) in the Mediation of IGF-II Activity

1999 • 43 citations

Effects of perinatal hypo- and hyperthyroidism on the levels of nerve growth factor and its low-affinity receptor in cerebellum

1993 • 43 citations

Autocrine Role of Insulin‐like Growth Factor II Secretion by the Rat Choroid Plexus

1996 • 37 citations

Basis of rabies virus neurovirulence in mice: expression of major histocompatibility complex class I and class II mRNAs

1999 • 36 citations

Differential Expression of the Insulin-Like Growth Factor II and Transthyretin Genes in the Developing Rat Choroid Plexus

1993 • 34 citations

Restricted Expression of the Actin-Regulatory Protein, Tropomyosin, Defines Distinct Boundaries, Evaginating Neuroepithelium, and Choroid Plexus Forerunners during Early CNS Development

1996 • 32 citations

Carbonic anhydrase activity during development of the choroid plexus in the human fetus

1997 • 32 citations

Development of potassium transport capability by choroid plexus of infant rats

1989 • 31 citations

Serotonin elevates intracellular Ca2+ in rat choroid plexus epithelial cells by acting on 5-HT2C receptors

1995 • 28 citations

Prostaglandin D₂ and sleep – a molecular genetic approach

1999 • 27 citations

N‐System Amino Acid Transport at the Blood‐CSF Barrier

1995 • 25 citations

Regulation of Neuronal Differentiation by Retinoic Acid Alone and in Cooperation with Thyroid Hormone or Hydrocortisone

1993 • 23 citations

In vivo demyelination by antimyelin antibodies

1980 • 18 citations

Extracellular Matrix Penetration by Epithelial Cells Is Influenced by Quantitative Changes in Basement Membrane Components and Growth Factors

1996 • 18 citations

Choline uptake across the ventricular membrane of neonate rat choroid plexus

1999 • 17 citations

Na+-dependent γ-aminobutyric acid (GABA) transport in the choroid plexus of rabbit

1997 • 13 citations

Angiotensin II regulates choroid plexus blood flow by interacting with the sympathetic nervous system and nitric oxide

1999 • 9 citations