Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Thioflavine T interaction with synthetic Alzheimer's disease β‐amyloid peptides: Detection of amyloid aggregation in solution

1993 • 2,137 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å

1978 • 784 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

1990 • 334 citations

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

1991 • 297 citations

The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

1993 • 295 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

1993 • 262 citations

In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to alzheimer's disease β-protein

1986 • 226 citations

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.

1992 • 209 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Human amyloidosis, Alzheimer disease and related disorders.

1988 • 177 citations

SP-40,40 is a constituent of Alzheimer's amyloid

1992 • 160 citations

[13] Isolation and characterization of apolipoprotein E

1986 • 155 citations

Solution Structure of Residues 1-28 of the Amyloid .beta.-Peptide

1994 • 144 citations

Soluble Amyloid β-Protein Is a Marker of Alzheimer Amyloid in Brain But Not in Cerebrospinal Fluid

1994 • 126 citations

Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease

1988 • 112 citations

Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.

1993 • 62 citations

Serum amysoid A protein, albumin and prealbumin in Alzheimer's disease and in demented patients with Down's syndrome

1986 • 49 citations

Sequestration of Amyloid β‐Peptide^a

1993 • 33 citations

Advances in Human Genetics

1991 • 31 citations

Production and functional analysis of normal and variant recombinant human transthyretin proteins.

1992 • 31 citations

Avid Binding of βA Amyloid Peptide to Its Own Precursor

1993 • 28 citations