Antagonism between Goalpha and Gqalpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goalpha signaling and regulates Gqalpha activity

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1974 • 14,589 citations

Inositol trisphosphate and calcium signalling

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Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

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The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

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Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Diversity of G Proteins in Signal Transduction

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Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

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1989 • 905 citations

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1992 • 871 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

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EGG-LAYING DEFECTIVE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1983 • 730 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

Caenorhabditis elegans : modern biological analysis of an organism

1995 • 689 citations

Toward a physical map of the genome of the nematode Caenorhabditis elegans

1986 • 631 citations

EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins

1996 • 573 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II

1990 • 550 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

RGS Proteins and Signaling by Heterotrimeric G Proteins

1997 • 522 citations

The C. elegans genome sequencing project: a beginning

1992 • 496 citations

The genetics of feeding in Caenorhabditis elegans.

1993 • 493 citations

A genetic mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites.

1992 • 487 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

A genetic selection for Caenorhabditis elegans synaptic transmission mutants.

1996 • 449 citations

Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

1992 • 441 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

RGS10 is a selective activator of Gαi GTPase activity

1996 • 354 citations

RGS2/G0S8 is a selective inhibitor of Gqα function

1997 • 342 citations

Sst2, a Negative Regulator of Pheromone Signaling in the Yeast Saccharomyces cerevisiae: Expression, Localization, and Genetic Interaction and Physical Association with Gpa1 (the G-Protein α Subunit)

1996 • 331 citations

Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.

1992 • 321 citations

G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways

1998 • 318 citations

Modulation of Serotonin-Controlled Behaviors by G _o in Caenorhabditis elegans

1995 • 309 citations

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

1995 • 291 citations

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

1998 • 289 citations

A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G _β5 subunits

1998 • 260 citations

The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.

1994 • 254 citations

Participation of the Protein G _o in Multiple Aspects of Behavior in C. elegans

1995 • 249 citations

Synthesis in Escherichia coli of GTPase-deficient mutants of Gsα

1989 • 247 citations

The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

1994 • 228 citations

A new family of G-protein regulators — the RGS proteins

1997 • 201 citations

Mutations in a C. elegans Gqα Gene Disrupt Movement, Egg Laying, and Viability

1996 • 196 citations

Regulation by cAMP-dependent protein kinease of a G-protein-mediated phospholipase C

1996 • 193 citations

Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.

1994 • 171 citations

Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein.

1990 • 146 citations

The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.

1995 • 132 citations

Direct sequencing from low-melt agarose with Sequenase@

1989 • 122 citations

Trimethylpsoralen induces small deletion mutations inCaenorhabditis elegans.

1994 • 119 citations

An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration.

1997 • 113 citations

Lifetime Regulation of G Protein–Effector Complex: Emerging Importance of RGS Proteins

1998 • 99 citations

Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins.

1987 • 95 citations

The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro

1997 • 90 citations

RGS3 and RGS4 are GTPase Activating Proteins in the Heart

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Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans.

1991 • 77 citations

Molecular characterization of Drosophila Gene Encoding G0 α Subunit Homolog

1989 • 72 citations

Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site.

1993 • 71 citations

Characterization of a G-protein β-subunit gene from the nematode Caenorhabditis elegans

1990 • 64 citations

Molecular cloning and sequence determination of a cDNA coding for the α‐subunit of a G_o‐type protein of Xenopus laevis oocytes

1989 • 57 citations

The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2.

1994 • 49 citations

Identification of X chromosome regions in Caenorhabditis elegans that contain sex-determination signal elements.

1994 • 49 citations

A Single Mutation Asp²²⁹→ Ser Confers upon G_sα the Ability To Interact with Regulators of G Protein Signaling

1998 • 34 citations

Isolation and mapping of DNA probes within the linkage group I gene cluster of Caenorhabditis elegans

1989 • 23 citations

Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Goα

1988 • 22 citations

Splicing in Caenorhabditis elegans Does Not Require an AG at the 3' Splice Acceptor Site

1993 • 19 citations