Induction of apoptosis in cervical carcinoma cells by peptide aptamers that bind to the HPV‐16 E7 oncoprotein

Cancer Cell Cycles

1996 • 5,379 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

1997 • 2,291 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent

1996 • 1,047 citations

Human papillomaviruses in the pathogenesis of anogenital cancer

1991 • 855 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2

1996 • 444 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein.

1996 • 329 citations

Viruses and apoptosis

1995 • 324 citations

Destabilization of the RB Tumor Suppressor Protein and Stabilization of p53 Contribute to HPV Type 16 E7-Induced Apoptosis

1997 • 260 citations

Tumor Antigen and Human Chorionic Gonadotropin in CaSki Cells: A New Epidermoid Cervical Cancer Cell Line

1977 • 253 citations

Modulation of type M ₂ pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

1999 • 247 citations

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

2000 • 238 citations

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1995 • 234 citations

Role of the human papillomaviruses in human cancer.

1991 • 212 citations

The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.

1996 • 212 citations

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.

1995 • 178 citations

Human papillomaviruses and associated malignancies.

1998 • 177 citations

Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint

1998 • 153 citations

Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions

1994 • 151 citations

The Human Papillomavirus E7 Oncoprotein Functionally Interacts with the S4 Subunit of the 26 S Proteasome

1997 • 148 citations

Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding

1993 • 135 citations

Human Papillomavirus E6 and E7: Proteins which deregulate the cell cycle

1995 • 133 citations

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein

1993 • 118 citations

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.

1990 • 117 citations

Regulation of the cell cycle by viral oncoproteins

1995 • 115 citations

An artificial cell-cycle inhibitor isolated from a combinatorial library

1998 • 111 citations

Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation

1999 • 110 citations

The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis

1998 • 106 citations

Adeno-associated virus-mediated gene delivery

1999 • 104 citations

Cell Transformation by the E7 Oncoprotein of Human Papillomavirus Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins

1999 • 92 citations

Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

2000 • 91 citations

The papillomavirus E6 proteins

1998 • 89 citations

Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix

1994 • 86 citations

Human papillomavirus type 16 E7 binds to the conserved carboxy-terminal region of the TATA box binding protein and this contributes to E7 transforming activity.

1997 • 84 citations

Targeting cyclin-dependent kinases in Drosophila with peptide aptamers

1998 • 84 citations

Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts

1993 • 61 citations

Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins

1998 • 53 citations

Synergism with Germ Line Transcription Factor Oct-4: Viral Oncoproteins Share the Ability To Mimic a Stem Cell-Specific Activity

1999 • 52 citations

The impact of two-hybrid and related methods on biotechnology

1998 • 49 citations

Combinatorial protein reagents to manipulate protein function

2000 • 49 citations

Allosteric Activation of Acid α-Glucosidase by the Human Papillomavirus E7 Protein

2000 • 48 citations

Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.

1996 • 43 citations

Human papillomavirus type 16 E6 and HPV-16 E6/E7 sensitize human keratinocytes to apoptosis induced by chemotherapeutic agents: Roles of p53 and caspase activation

2000 • 38 citations

Induction of Transformation and p53-Dependent Apoptosis by Adenovirus Type 5 E4orf6/7 cDNA

1999 • 35 citations

Identification of domains required for transcriptional activation and protein dimerization in the human papillomavirus type-16 E7 protein.

1996 • 34 citations

p53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene.

1996 • 33 citations

Molecular switches that govern the balance between proliferation and apoptosis

2000 • 31 citations

The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury

1998 • 19 citations