Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors

Sequences of proteins of immunological interest

1984 • 3,427 citations

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

1990 • 593 citations

Differential Expression of Proliferation-Associated Molecules in Individual Micrometastatic Carcinoma Cells

1993 • 514 citations

A comparison of strategies to stabilize immunoglobulin Fv-fragments

1990 • 469 citations

Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers

1991 • 452 citations

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

1987 • 449 citations

Recombinant Toxins for Cancer Treatment

1991 • 308 citations

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

1988 • 259 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

Treatment of advanced solid tumors with immunotoxin LMB–1: An antibody linked to Pseudomonas exotoxin

1996 • 208 citations

Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor.

1992 • 188 citations

A Deletion Mutation within the Ligand Binding Domain Is Responsible for Activation of Epidermal Growth Factor Receptor Gene in Human Brain Tumors

1990 • 158 citations

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.

1992 • 158 citations

A Murine Renal Cell Carcinoma

1973 • 149 citations

Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments

1996 • 138 citations

Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: Targeting with a single chain antibody variable domain isolated by phage display

1996 • 134 citations

Therapeutic application of anti-growth factor receptor antibodies

1998 • 121 citations

Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function.

1985 • 104 citations

EGF receptor and p185^erbB‐2‐specific single‐chain antibody toxins differ in their cell‐killing activity on tumor cells expressing both receptor proteins

1995 • 98 citations

Thermal stabilization of a single‐chain Fv antibody fragment by introduction of a disulphide bond

1995 • 75 citations

Specific targeting of a mutant, activated egf receptor found in glioblastoma using a monoclonal antibody

1995 • 67 citations

VI-Linker-Vh Orientation-Dependent Expression of Single Chain Fv Containing an Engineered Disulfide-Stabilized Bond in the Framework Regions1

1995 • 54 citations

Systemic treatment with a recombinant erbB-2 receptor-specific tumor toxin efficiently reduces pulmonary metastases in mice injected with genetically modified carcinoma cells.

1998 • 53 citations

Construction and functional characterization of scFv(14E1)-ETA - a novel, highly potent antibody-toxin specific for the EGF receptor

1997 • 45 citations

Micrometastasis Detection and Treatment with Monoclonal Antibodies

1996 • 39 citations

Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF‐receptor‐specific antibody‐toxin

1998 • 30 citations

Targeted therapy of Schwannoma cells in immunocompetent rats with an erbB2-specific antibody-toxin

1997 • 23 citations

Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF-receptor-specific antibody-toxin

1998 • 21 citations

Intervention in Receptor Tyrosine Kinase-Mediated Pathways: Recombinant Antibody Fusion Proteins Targeted to ErbB2

1996 • 13 citations

Intra-tumoral application of a heregulin-exotoxin-A fusion protein causes rapid tumor regression without adverse systemic or local effects

1997 • 11 citations

Purging of Mammary Carcinoma Cells During Ex Vivo Culture of CD34+ Hematopoietic Progenitor Cells With Recombinant Immunotoxins

1998 • 4 citations