Polymorphic Drug Oxidation

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

1994 • 749 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

Advances in Drug Research

1964 • 615 citations

Significance of Neuroleptic Dose and Plasma Level in the Pharmacological Treatment of Psychoses

1988 • 554 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Relationship between Plasma Level and Therapeutic Effect of Nortriptyline

1971 • 467 citations

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1985 • 459 citations

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

1992 • 456 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

1993 • 370 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Human cytochromes P450: problems and prospects

1992 • 364 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects

1993 • 311 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Pharmacogenetics of drug metabolism

1980 • 310 citations

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

1990 • 304 citations

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.

1994 • 301 citations

Genetic polymorphism of S-mephenytoin hydroxylation

1989 • 292 citations

Pharmacokinetics of Haloperidol

1989 • 292 citations

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

1993 • 286 citations

The use of caffeine for enzyme assays: A critical appraisal

1993 • 282 citations

Frontiers in Biochemical and Pharmacological Research in Depression

1984 • 278 citations

Fluvoxamine Inhibition and Carbamazepine Induction of the Metabolism of Clozapine

1994 • 276 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism

1984 • 271 citations

Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds

1967 • 266 citations

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

1990 • 263 citations

Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype

1989 • 257 citations

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles ofCYP2D6in a European Population

1991 • 224 citations

Diazepam metabolism by human liver microsomes is mediated by both S‐ mephenytoin hydroxylase and CYP3A isoforms.

1994 • 223 citations

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1989 • 221 citations

Pharmacokinetics of Citalopram in Relation to the Sparteine and the Mephenytoin Oxidation Polymorphisms

1993 • 214 citations

Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype

1995 • 206 citations

The relationship between paroxetine and the sparteine oxidation polymorphism

1992 • 204 citations

Clinical Pharmacology in Psychiatry

1981 • 198 citations

The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR-12935 binding proteins

1990 • 193 citations

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1992 • 190 citations

Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and age

1989 • 179 citations

Drug Interaction: Inhibitory Effect of Neuroleptics on Metabolism of Tricyclic Antidepressants in Man

1972 • 176 citations

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.

1985 • 173 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in luman beings

1989 • 167 citations

Advances in Drug Metabolism in Man

1995 • 167 citations

The activation of the biguanide antimalarial proguanil co‐segregates with the mephenytoin oxidation polymorphism‐a panel study.

1991 • 162 citations

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1991 • 162 citations

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1982 • 160 citations

Haloperidol Disposition Is Dependent on Debrisoquine Hydroxylation Phenotype

1992 • 157 citations

Ethnic Differences in Reactions to Drugs and Xenobiotics

1987 • 156 citations

Ethnic Differences in Drug Disposition and Responsiveness

1991 • 154 citations

Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

1988 • 152 citations

D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate

1995 • 148 citations

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1991 • 147 citations

Plasma Level Monitoring of Antipsychotic Drugs Clinical Utility

1986 • 147 citations

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism

1993 • 146 citations

Relationship between personality and debrisoquine hydroxylation capacity

1993 • 145 citations

Extremely Rapid Hydroxylation of Debrisoquine

1985 • 144 citations

Debrisoquine 4-Hydroxylase: Characterization of a New P450 Gene Subfamily, Regulation, Chromosomal Mapping, and Molecular Analysis of the DA Rat Polymorphism

1987 • 139 citations

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1991 • 139 citations

Therapeutic drug monitoring of tricyclic antidepressants.

1988 • 138 citations

Genetically variable metabolism of antidepressants and neuroleptic drugs in man

1993 • 136 citations

Effect of Fluvoxamine on the Pharmacokinetics of Imipramine and Desipramine in Healthy Subjects

1993 • 135 citations

MPTP, the neurotoxin inducing parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation

1987 • 130 citations

Interethnic variation of drug metabolism

1991 • 128 citations

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics

1992 • 121 citations

The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6.

1992 • 116 citations

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

1989 • 116 citations

Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and multiple oral doses ? A cross-over study

1972 • 112 citations

Neuroleptic dosage for Asians

1983 • 112 citations

Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.

1985 • 111 citations

Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man

1980 • 111 citations

Plasma Level Monitoring of Tricyclic Antidepressant Therapy

1977 • 111 citations

Plasma Level Monitoring of Antipsychotic Drugs

1978 • 110 citations

Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans.

1993 • 108 citations

Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase).

1991 • 106 citations

Haloperidol and Prolactin Concentrations in Asians and Caucasians

1988 • 104 citations

Disposition of clozapine in man: lack of association with debrisoquine and S‐mephenytoin hydroxylation polymorphisms.

1994 • 103 citations

Haloperidol Disposition Is Dependent on the Debrisoquine Hydroxylation Phenotype

1992 • 99 citations

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

1986 • 98 citations

Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

1995 • 98 citations

Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects

1995 • 96 citations

Haloperidol concentrations elevated in Chinese patients

1984 • 96 citations

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1991 • 95 citations

Inhibition of diazepam metabolism by fluvoxamine: A pharmacokinetic study in normal volunteers

1994 • 94 citations

The debrisoquine hydroxylation test predicts steady‐state plasma levels of desipramine.

1983 • 93 citations

Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes

1985 • 91 citations

The pharmacogenetics of the selective serotonin reuptake inhibitors

1993 • 90 citations

Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations.

1991 • 89 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

1988 • 87 citations

Genetic control of nortriptyline kinetics in man: a study of relatives of propositi with high plasma concentrations.

1971 • 86 citations

Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe*

1995 • 84 citations

Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes

1984 • 82 citations

Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers

1986 • 82 citations

Inhibitory effects of neuroleptics on debrisoquine oxidation in man.

1986 • 79 citations

Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites

1986 • 77 citations

Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics

1986 • 77 citations

Differences in diazepam pharmacokinetics in Chinese and white Caucasians ? Relation to body lipid stores

1987 • 77 citations

Interaction Between Fluvoxamine and Imipramine/Desipramine in Four Patients

1992 • 75 citations

Diazepam effects and kinetics in Caucasians and Orientals

1981 • 74 citations

Caffeine metabolism in a healthy Spanish population: N-Acetylator phenotype and oxidation pathways

1994 • 74 citations

Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions

1994 • 72 citations

Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

1984 • 71 citations

Amitriptyline metabolism: Relationship to polymorphic debrisoquine hydroxylation

1983 • 70 citations

Plasma concentrations of nortriptyline and its 10‐hydroxy metabolite in depressed patients‐relationship to the debrisoquine hydroxylation metabolic ratio.

1985 • 69 citations

A comparative study of the metabolism of desmethylimipramine, nortriptyline, and oxyphenylbutazone in man

1969 • 69 citations

Active Hydroxymetabolites of Antidepressants

1995 • 67 citations

Debrisoquine oxidation polymorphism

1993 • 66 citations

Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans

1991 • 65 citations

Drug Interactions With Antipsychotic Agents

1993 • 63 citations

The Use of Therapeutic Drug Monitoring Data to Document Kinetic Drug Interactions

1994 • 61 citations

Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man

1982 • 61 citations

Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: Interethnic differences in comparison with white subjects

1990 • 59 citations

Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population

1993 • 56 citations

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

1994 • 54 citations

Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype

1987 • 50 citations

Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level

1972 • 49 citations

Clinical and biochemical effects during treatment of depression with nortriptyline: The role of 10-hydroxynortriptyline

1987 • 44 citations

High Blood Concentrations of Imipramine or Clomipramine and Therapeutic Failure

1989 • 41 citations

Maprotiline metabolism appears to co‐segregate with the genetically‐ determined CYP2D6 polymorphic hydroxylation of debrisoquine.

1994 • 40 citations

Interconversion between haloperidol and reduced haloperidol in healthy volunteers

1989 • 36 citations

The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma

1984 • 34 citations

Clinical pharmacology of antidepressant drugs: pharmacogenetics.

1984 • 33 citations

Pharmacokinetic and other related factors affecting psychotropic responses in Asians.

1991 • 32 citations

Polymorphic 2-hydroxylation of desipramine

1993 • 29 citations

Steady-State Plasma Levels of E- and Z-10-OH-Nortriptyline in Nortriptyline-Treated Patients

1989 • 29 citations

Role of Genetic Polymorphism in Psychopharmacology — An Update

1993 • 27 citations

Thioridazine Effect on Desipramine Plasma Levels

1983 • 26 citations

Genetic relationship of human populations and ethnic differences in reaction to drugs and food.

1986 • 26 citations

Nonlinear Kinetics of Imipramine in Low and Medium Plasma Level Ranges

1990 • 23 citations

Intraindividual Similarity in the Metabolism of Amitriptyline and Chlorimipramine in Depressed Patients

1979 • 18 citations

Slow hydroxylation of tricyclic antidepressants--relationship to polymorphic drug oxidation.

1986 • 16 citations

E- and Z-10-hydroxylation of nortriptyline by human liver microsomes--methods and characterization.

1983 • 14 citations