Plasma concentrations of nortriptyline and its 10‐hydroxy metabolite in depressed patients‐relationship to the debrisoquine hydroxylation metabolic ratio.

Nonparametric Statistics for the Behavioral Sciences

1958 • 36,277 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline

1979 • 106 citations

The debrisoquine hydroxylation test predicts steady‐state plasma levels of desipramine.

1983 • 93 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

A gas chromatographic method for the quantitative determination of nortriptyline and some of its metabolites in human plasma and urine

1972 • 82 citations

Prediction of steady-state plasma levels of nortriptyline from single oral dose kinetics: A study in twins

1973 • 64 citations

Genetically determined oxidation capacity and the disposition of debrisoquine.

1983 • 60 citations

Nortriptyline metabolism in chronic renal failure: Metabolite elimination

1982 • 48 citations

Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects

1984 • 26 citations

GUANETHIDINE AND RELATED AGENTS. II. METABOLISM BY HEPATIC MICROSOMES AND ITS INHIBITION BY DRUGS

1970 • 26 citations

Correlation between nortriptyline and debrisoquine hydroxylation in the human liver

1983 • 20 citations

Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors

1984 • 17 citations

Stereospecific 10-hydroxylation of nortriptyline — genetic aspects and importance for biochemical and clinical effects

1983 • 4 citations

Accumulation of debrisoquine by platelets in vivo: a model of events at the peripheral adrenergic neurone.

1980 • 2 citations