Ethnic Differences in Drug Disposition and Responsiveness

Pentoxifylline

1987 • 1,768 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Genetic Control of Isoniazid Metabolism in Man

1960 • 792 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

N-acetylation pharmacogenetics.

1985 • 637 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1985 • 459 citations

Polymorphic dextromethorphan metabolism: Co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

1985 • 386 citations

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1984 • 386 citations

Effect of Acetylator Phenotype on the Rate at Which Procainamide Induces Antinuclear Antibodies and the Lupus Syndrome

1978 • 382 citations

Reduction of Liver Blood Flow and Propranolol Metabolism by Cimetidine

1981 • 379 citations

Developmental changes and polymorphism in human alcohol dehydrogenase

1971 • 375 citations

Isoniazid-Associated Hepatitis in 114 Patients

1975 • 372 citations

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Ketorolac

1990 • 352 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites

1975 • 301 citations

Clinical Pharmacokinetics of β-Adrenoreceptor Blocking Drugs

1976 • 295 citations

Oxidation Phenotype — A Major Determinant of Metoprolol Metabolism and Response

1982 • 283 citations

Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism

1984 • 271 citations

Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine.

1970 • 257 citations

Plasma cholinesterase variants and the anaesthetist

1980 • 240 citations

An improved and simplified method of detecting the acetylator phenotype.

1969 • 238 citations

Racial Differences in Drug Response

1989 • 236 citations

Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis.

1954 • 231 citations

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1989 • 221 citations

Relationship between facial flushing and blood acetaldehyde levels after alcohol intake

1979 • 221 citations

PHENYLBUTAZONE AND ISONIAZID METABOLISM IN PATIENTS WITH LIVER DISEASE IN RELATION TO PREVIOUS DRUG THERAPY

1968 • 196 citations

Regulation of Human Leukocyte Beta Receptors by Endogenous Catecholamines

1981 • 194 citations

AN ATYPICAL HUMAN ALCOHOL DEHYDROGENASE

1965 • 191 citations

Effects of age and cigarette smoking on propranolol disposition

1979 • 186 citations

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

1984 • 185 citations

Proposed Mechanisms of Propranolol's Antihypertensive Effect in Essential Hypertension

1976 • 179 citations

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.

1985 • 173 citations

Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.

1975 • 173 citations

N-acetyltransferase polymorphism

1991 • 171 citations

Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese

1983 • 168 citations

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1982 • 160 citations

Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues

1980 • 159 citations

Metoprolol metabolism and debrisoquine oxidation polymorphism‐ population and family studies.

1985 • 157 citations

Peripheral neuritis due to isoniazid.

1960 • 149 citations

A KINETIC STUDY OF DRUG ELIMINATION: THE EXCRETION OF PARACETAMOL AND ITS METABOLITES IN MANMETABOLITES IN MAN

1967 • 143 citations

The effect of age on plasma levels of propranolol and practolol in man.

1975 • 139 citations

Polymorphic debrisoquin hydroxylation in 757 Swedish subjects

1988 • 135 citations

Variations between individuals and populations in the acetylation of isoniazid and its significance for the treatment of pulmonary tuberculosis

1976 • 134 citations

Genetical and Geographic Studies on Isoniazid Inactivation

1961 • 132 citations

A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin

1985 • 127 citations

Defective metabolism of metoprolol in poor hydroxylators of debrisoquine.

1982 • 125 citations

Genetic control of ethanol action on the central nervous system

1977 • 123 citations

ATYPICAL HUMAN LIVER ALCOHOL DEHYDROGENASE

1968 • 116 citations

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

1989 • 116 citations

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine.

1989 • 115 citations

Catechol-O-methyltransferase activity: A determinant of levodopa response

1980 • 114 citations

Pharmacokinetics of oral propranolol in chronic renal disease

1974 • 113 citations

Neuroleptic dosage for Asians

1983 • 112 citations

Ineffectiveness of propranolol in hypertensive Jamaicans.

1968 • 108 citations

Haloperidol and Prolactin Concentrations in Asians and Caucasians

1988 • 104 citations

Haloperidol concentrations elevated in Chinese patients

1984 • 96 citations

Racial differences in response to low-dose captopril are abolished by the addition of hydrochlorothiazide.

1982 • 93 citations

Effects of long-term treatment with procaine amide. A prospective study with special regard to ANF and SLE in fast and slow acetylators.

1975 • 93 citations

Genetically determined polymorphisms in drug oxidation

1986 • 88 citations

Comparison of alprazolam plasma levels in normal Asian and Caucasian male volunteers

1988 • 88 citations

Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: Gene deletion and its possible implications in alcohol metabolism

1981 • 87 citations

Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians

1979 • 85 citations

Differences in plasma binding of drugs between Caucasians and Chinese subjects

1990 • 85 citations

Haloperidol Decanoate

1987 • 85 citations

Ethanol metabolism in subiects possessing typical and atypical liver alcohol dehydrogenase

1967 • 84 citations

Pharmacotherapy of Hispanic Depressed Patients: Clinical Observations

1982 • 83 citations

The Influence of Cirrhosis on Steady-State Blood Concentrations of Unbound Propranolol after Oral Administration1

1978 • 83 citations

Extrapyramidal reactions in Asians

1981 • 83 citations

Lack of relationship between hepatic toxicity and acetylator phenotype in three thousand South Indian patients during treatment with isoniazid for tuberculosis.

1984 • 82 citations

Ethnicity and psychopharmacology

1986 • 82 citations

Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade

1984 • 81 citations

Inhibitory effects of neuroleptics on debrisoquine oxidation in man.

1986 • 79 citations

Differences in diazepam pharmacokinetics in Chinese and white Caucasians ? Relation to body lipid stores

1987 • 77 citations

Ketanserin

1990 • 76 citations

Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics.

1985 • 75 citations

Inhibition of propranolol metabolism by chlorpromazine

1979 • 75 citations

Diazepam effects and kinetics in Caucasians and Orientals

1981 • 74 citations

Diphenhydramine in Orientals and Caucasians

1980 • 72 citations

Quinidine reduces clearance of (+)-propranolol more than (−)-propranolol through marked reduction in 4-hydroxylation

1990 • 71 citations

Trial of atenolol and chlorthalidone for hypertension in black South Africans.

1980 • 71 citations

Ethanol-induced increase in drug acetylation in man and isolated rat liver cells.

1978 • 69 citations

Difference in erythrocyte catechol-O-methyltransferase activity between Orientals and Caucasians: Difference in levodopa tolerance

1984 • 68 citations

Sparteine Oxidation Polymorphism in Denmark

1985 • 68 citations

The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol.

1984 • 66 citations

Genetic polymorphism in drug oxidation: In vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1′-hydroxylase activities

1985 • 65 citations

Environmental factors affecting paracetamol metabolism in London factory and office workers.

1980 • 65 citations

The Clinical Picture and Plasma Levodopa Metabolite Profile of Parkinsonian Nonresponders

1977 • 64 citations

Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians

1985 • 63 citations

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

1980 • 63 citations

Metoprolol and debrisoquin metabolism in nigerians: Lack of evidence for polymorphic oxidation

1986 • 62 citations

Buserelin

1990 • 61 citations

Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin

1985 • 60 citations

Genetics of Isoniazid Metabolism in Caucasian, Negro, and Japanese Populations

1964 • 59 citations

The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population

1980 • 59 citations

A Population and Familial Study of the Defective Alicyclic Hydroxylation of Debrisoquine among Egyptians

1979 • 57 citations

Human alcohol dehydrogenase ADH2 and ADH3 polymorphisms in ethnic Chinese and Indians of West Malaysia

1979 • 54 citations

Debrisoquin oxidation polymorphism in a Spanish population

1988 • 51 citations

Comparison of propranolol and hydrochlorothiazide for thr initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences in response. Veterans Administration Cooperative Study Group on Antihypertensive agents

1982 • 51 citations

Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis

1989 • 50 citations

Ethnic difference in drug metabolism: debrisoquine 4-hydroxylation in Caucasians and Orientals

1980 • 50 citations

On the identification and frequency of the J and K cholinesterase phenotypes in a Caucasian population.

1984 • 50 citations

Haloperidol and reduced haloperidol plasma levels in Chinese vs. non-Chinese psychiatric patients

1989 • 49 citations

Labetalol

1989 • 48 citations

Interindividual differences in plasma protein binding of nortriptyline in man ? A twin study

1972 • 48 citations

Low plasma reduced haloperidol/haloperidol ratios in chinese patients

1987 • 47 citations

Dapsone-Induced Peripheral Neuropathy

1977 • 45 citations

A comparison between the behavior of Eskimos and non-Eskimos to the administration of isoniazid.

1960 • 45 citations

Dapsone-Induced Peripheral Neuropathy

1984 • 41 citations

Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians

1984 • 41 citations

Effect of prednisolone and rifampin on isoniazid metabolism in slow and rapid inactivators of isoniazid

1980 • 39 citations

A method for studying drug metabolism in populations: Racial differences in amobarbital metabolism

1979 • 39 citations

S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families

1987 • 38 citations

Liver alcohol dehydrogenase in a Japanese population.

1972 • 38 citations

Debrisoquine oxidation in an Australian population.

1986 • 37 citations

Antidepressant agents--a cross-cultural study.

1980 • 37 citations

Family studies of mephenytoin hydroxylation deficiency.

1986 • 37 citations

Differences in the effects of clomipramine on English and Asian volunteers. Preliminary report on a pilot study.

1977 • 36 citations

Acetylator phenotyping of tuberculosis patients using matrix isoniazid or sulphadimidine and its prognostic significance for treatment with several intermittent isoniazid‐containing regimens.

1977 • 35 citations

Polymorphic metabolism of metoprolol: Clinical studies

1985 • 32 citations

Ethnic Differences in Response to β1Adrenoceptor Blockade by Propranolol

1984 • 32 citations

Isoniazid pharmacokinetics in patients in chronic renal failure.

1976 • 31 citations

Contribution of the genetic status of oxidative metabolism to variability in the plasma concentrations of beta-adrenoceptor blocking agents

1983 • 30 citations

Pharmacokinetic and pharmacodynamic modelling of trimazosin and its major metabolite

1983 • 30 citations

[Drug hydroxylation disorders (debrisoquin type) in a random sample of the Swiss population].

1982 • 29 citations

Genetics of drug transformation

1986 • 29 citations

Suppression of ventricular arrhythmias in man by d-propranolol independent of beta-adrenergic receptor blockade.

1990 • 29 citations

3-O-Methyldopa, L-dopa, and trihexyphenidyl in the treatment of Parkinson's disease.

1973 • 28 citations

Amitriptyline overdose: clinical effects on tricyclic antidepressant plasma levels.

1982 • 28 citations

Psychopharmacology for Asian Americans and Pacific Islanders.

1979 • 27 citations

Ethnic differences in drug response.

1980 • 26 citations

N‐acetylation phenotyping with dapsone in a mainland Chinese population.

1988 • 25 citations

The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum

1969 • 25 citations

Lithium treatment in affective disorders: therapeutic plasma level.

1979 • 25 citations

Influence of age, sex and body weight on the dapsone acetylation phenotype.

1987 • 24 citations

Distinctive patterns of amobarbital metabolites

1978 • 24 citations

Determination of the acetylator phenotype using matrix isoniazid

1975 • 24 citations

Nortriptyline Kinetics in Hispanic and Anglo Subjects

1986 • 23 citations

N‐acetylation polymorphism of dapsone in a Japanese population.

1988 • 22 citations

Ethnic differences in cyclic AMP accumulation: Effect on α2, β2, and prostanoid receptor responses

1990 • 22 citations

A study of labetalol in patients of European, West Indian and West African origin.

1976 • 21 citations

Differential Sensitivity to the Effects of Psychotropic Drugs: Psychotics vs Normals; Asian vs Western Populations

1981 • 21 citations

FURTHER OBSERVATIONS ON TRIMODALITY OF FREQUENCY DISTRIBUTION CURVE OF BIOLOGICALLY ACTIVE ISONIAZID BLOOD LEVELS AND "CLINE" INFREQUENCIES OF ALLELES CONTROLLING ISONIAZID INACTIVATION.

1963 • 21 citations

Differences in stereoselective disposition of propranolol do not explain sensitivity differences between white and Chinese subjects: Correlation between the clearance of (−)- and (+)-propranolol

1990 • 20 citations

Determination of the acetylator phenotype in a Northern Nigerian population

1975 • 20 citations

Racial differences in drug response: Isoproterenol effects on heart rate following intravenous metoprolol

1989 • 19 citations

Controlled trial of intermittent regimens of rifampin plus isoniazid for pulmonary tuberculosis in Singapore. The results up to 30 months.

1977 • 19 citations

Sparteine oxidation by the human liver: Absence of inhibition by mephenytoin

1984 • 19 citations

Sparteine oxidation polymorphism in Greenlanders living in Denmark.

1986 • 18 citations

Interindividual differences in β-receptor density contribute to variability in response to β-adrenoceptor antagonists

1989 • 18 citations

Some Differences in Response to Atropine in White and Colored Races.

1921 • 17 citations

Pharmacoanthropology: drug metabolism.

1984 • 17 citations

Distribution of isoniazid inactivators determined in Eskimos and Canadian college students by a urine test.

1974 • 14 citations

Ethnic differences in human lymphocytic cyclic AMP production after isoprenaline stimulation and propranolol blockade.

1985 • 14 citations

Once-daily atenolol in hypertensive Zimbabwean blacks. A double-blind trial using two different doses.

1981 • 14 citations

Genetic control of interindividual variations in racemic warfarin binding to plasma and albumin of twins

1977 • 12 citations

The effect of atropine on heart‐rate: a comparison between two ethnic groups.

1988 • 12 citations

Family study of genetic and environmental factors determining the protein binding of propranolol

1983 • 9 citations

Racial differences in drug response: isoproterenol effects on heart rate in healthy males.

1989 • 9 citations

Racial differences in drug responses‐a comparative study of trimazosin and alpha 1‐adrenoceptor responses in normotensive Caucasians and West Africans.

1986 • 9 citations

Ethnic differences in response to beta-blockade: Fact or artefact? A study with bisoprolol and propranolol

1988 • 8 citations

[A survey of debrisoquin hydroxylation polymorphism].

1986 • 7 citations

Plasma cholinesterase variants in population samples from south-west France

1981 • 7 citations

Population genetic studies of the Aka Pygmies (Central Africa)

1979 • 7 citations

The effect of propranolol on exercise induced tachycardia is determined by plasma concentration and the density of adrenergic receptors on leukocytes

1987 • 6 citations

Protein binding of ampicillin. Path analysis of a twin material

2009 • 5 citations

Ethanol metabolism.

1980 • 5 citations

Deleted Work

1955 • 0 citations