Plasma Level Monitoring of Antipsychotic Drugs

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Advances in biochemical psychopharmacology

1970 • 1,186 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1970 • 534 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

Mass fragmentography

1968 • 303 citations

A simple and sensitive radioreceptor assay for antischizophrenic drugs in blood

1977 • 242 citations

Drug Interaction: Inhibitory Effect of Neuroleptics on Metabolism of Tricyclic Antidepressants in Man

1972 • 176 citations

Clinical response and plasma levels: effect of dose, dosage schedules, and drug interactions on plasma chlorpromazine levels

1976 • 153 citations

Effects of mode of management on plasma chlorpromazine in psychiatric patients

1973 • 148 citations

Physiologic and clinical effects of chlorpromazine and their relationship to plasma level

1972 • 142 citations

Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma by using gas-liquid chromatography with an electron capture detector

1968 • 139 citations

THE PRESENT STATUS OF PSYCHOTROPIC DRUGS

1966 • 137 citations

ABSORPTION AND DISTRIBUTION OF DRUGS

1963 • 123 citations

Distribution, excretion and metabolism of neuroleptics of the butyrophenone type

1967 • 123 citations

Pharmacokinetic studies on haloperidol in man.

1976 • 119 citations

Factors Affecting Chlorpromazine Plasma Levels in Psychiatric Patients

1970 • 106 citations

THE RELATIONSHIP OF PLASMA CHLORPROMAZINE TO ITS 7‐HYDROXY AND SULPHOXIDE METABOLITES IN A LARGE POPULATION OF CHRONIC SCHIZOPHRENICS

1974 • 105 citations

Phenothiazines and structurally related drugs

1974 • 104 citations

Pharmacokinetics of chlorpromazine after single and chronic dosage

1977 • 101 citations

Clinical effects and drug concentrations in plasma and cerebrospinal fluid in psychotic patients treated with fixed doses of chlorpromazine

1978 • 98 citations

Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

1975 • 92 citations

A gas chromatographic method for determining haloperidol

1974 • 84 citations

Clinical pharmacokinetic studies of perphenazine.

1976 • 83 citations

The possible role of metabolites in therapeutic response to chlorpromazine treatment

1973 • 78 citations

Neuroleptic drug levels and therapeutic response: preliminary observations with red blood cell bound butaperazine

1977 • 75 citations

Clinical significance of plasma chlorpromazine levels I. Plasma levels of the drug, some of its metabolites and prolactin during acute treatment

1976 • 74 citations

Plasma Levels of Chlorpromazine in Schizophrenia

1978 • 72 citations

Dystonic reactions following neuroleptics: Time Course and proposed mechanisms

1976 • 67 citations

Anodic coulometric detection with a glassy carbon electrode in combination with reversed-phase high-performance liquid chromatography

1976 • 66 citations

GLC Analysis of Loxapine, Amoxapine, and Their Metabolites in Serum and Urine

1979 • 61 citations

Factors Influencing Spectrofluorometry of Phenothiazine Drugs.

1964 • 61 citations

Clinical significance of plasma chlorpromazine levels. II. Plasma levels of the drug, some of its metabolites and prolactin in patients receiving long-term phenothiazine treatment.

1976 • 60 citations

A mass fragmentographic method for the determination of chlorpromazine and two of its active metabolites in human plasma and CSF

1976 • 59 citations

Modification of chlorpromazine metabolism by some other drugs frequently administered to psychiatric patients.

1970 • 59 citations

Distribution excretion and metabolism of neuroleptics of the butyrophenone type

1967 • 59 citations

PROGRESS IN PSYCHIATRIC DRUG TREATMENT

1977 • 57 citations

ON THE METABOLISM OF HALOPERIDOL IN MAN.

1977 • 56 citations

A gas chromatographic method for the determination of haloperidol in human plasma

1971 • 54 citations

Destruction of chlorpromazine during absorption in the rat in vivo and in vitro

1971 • 52 citations

Correlation Between Plasma Chlorpromazine and its Metabolites and Clinical Ratings in Patients with Acute Relapse of Schizophrenic and Paranoid Psychosis

1977 • 51 citations

Concentrations plasmatiques de l'imipramine et de la desmethylimipramine et effet anti-depresseur au cours d'un traitement control�

1975 • 50 citations

The Assay of Chlorpromazine and Metabolites in Blood, Urine, and Other Tissues

1971 • 49 citations

Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations

1979 • 48 citations

Determination of phenothiazines in biological samples

1965 • 44 citations

Pharmacokinetics of Red Blood Cell Phenothiazine and Clinical Effects

1976 • 44 citations

Thioridazine plasma levels and clinical response

1975 • 44 citations

Plasma levels and half lives of thioridazine and some of its metabolites

1977 • 40 citations

Serum levels of thioridazine in psychiatric patients and healthy volunteers

1973 • 39 citations

Plasma concentrations of perphenazine and its sulphoxide metabolite during continuous oral treatment

1977 • 38 citations

Pharmacokinetics and relative bioavailability of levomepromazine after repeated administration of tablets and syrup

1977 • 38 citations

Development of radioimmunoassay for chlorpromazine

1975 • 38 citations

Thymoleptic and Neuroleptic Drug Plasma Levels in Psychiatry: Current Status

1976 • 38 citations

Effects of perphenazine on imipramine metabolism in man.

1975 • 37 citations

Monitoring Plasma Concentrations of Neuroleptics^*

1976 • 36 citations

Plasma Levels and Clinical Effects of Thioridazine and Thiothixene

1975 • 36 citations

Influence of the antiparkinsonian drugs on the plasma level of neuroleptics.

1977 • 35 citations

A method for the fluorimetric determination of thioridazine (Mellaril®) or mesoridazine (Lidanil®) in Plasma

1969 • 35 citations

Pharmacokinetics of thiothixene in man

1974 • 33 citations

Prediction of response to chlorpromazine treatment in schizophrenics

1975 • 32 citations

Gas chromatographic identification of thioridazine in plasma, and a method for routine assay of the drug

1969 • 31 citations

Effect of lithium on plasma chlorpromazine levels

1978 • 31 citations

Analytical and pharmacokinetic studies on butyrophenones

1971 • 30 citations

Factors influencing the metabolism of tricyclic antidepressants. Studies on interactions and first pass elimination.

1977 • 30 citations

Chlorpromazine: Effects of Antacids on Its Gastrointestinal Absorption

1973 • 30 citations

GLC analysis of thioridazine, mesoridazine, and their metabolites

1976 • 28 citations

A method for the gas chromatographic determination of butyrophenones

1971 • 28 citations

Chlorpromazine Metabolism I: Quantitative Fluorometric Method for 11 Chlorpromazine Metabolites

1970 • 27 citations

Serum concentration and elimination from serum of thioridazine in psychiatric patients.

1976 • 26 citations

Perphenazine concentrations in human whole blood

1974 • 24 citations

Determination of perphenazine and fluphenazine in whole blood by gas chromatography.

1973 • 23 citations

Detection of chlorpromazine and thioridazine metabolites in human erythrocytes

1969 • 23 citations

Determination of Thioxanthenes in Plasma at Therapeutic Concentrations

1971 • 22 citations

Relationships among clinical response, extrapyramidal syndrome and plasma chlorpromazine and metabolite ratios.

1977 • 22 citations

Measurement of thioridazine in blood and urine.

1977 • 20 citations

Pharmacokinetics of psychoactive drugs : blood levels and clinical response

1976 • 19 citations

Tricyclic Antidepressants And Phenothiazines

1974 • 18 citations

Measurement of Plasma and Erythrocyte Chlorpromazine and N‐Monodesmethylchlorpromazine Levels by Gas Chromatography with a Nitrogen Sensitive Detector

1978 • 17 citations

A method for determination of chlorpromazine in human blood serum

1972 • 17 citations

The Effect of Benztropine Mesylate on Plasma Levels of Butaperazine Maleate

1974 • 17 citations

Inter-patient variation in chlorpromazine metabolism.

1965 • 16 citations

Plasma levels and half lives of thioridazine and some of its metabolites

1977 • 16 citations

Effect of lithium on gastric emptying and absorption of oral chlorpromazine.

1976 • 15 citations

Butaperazine Pharmacokinetics

1975 • 15 citations

Plasma levels of mesoridazine and its metabolites and clinical response in acute schizophrenia after a single intramuscular drug dose.

1975 • 14 citations

The Relationship Between Blood Levels of Different Forms of Butaperazine and Clinical Response

1973 • 14 citations

Chlorpromazine Metabolism II: Determination of Nonconjugated Metabolites in Blood of Schizophrenie Patients

1972 • 13 citations

Distribution of penfluridol in rats and mice

1974 • 13 citations

Red blood cell drug binding as a possible mechanism for tranquilization.

1974 • 13 citations

Chlorpromazine metabolism and clinical response in acute schizophrenia: a preliminary report.

1975 • 13 citations

The pharmacokinetics of butaperazine in serum.

1974 • 12 citations

PLASMA CONCENTRATIONS OF THIORIDAZINE IN PATIENTS WITH DEPRESSION. A preliminary report

1970 • 12 citations

A preliminary report on clinical response and blood levels of chlorpromazine and its sulfoxide during chlorpromazine therapy in chronic schizophrenic patients.

1975 • 11 citations

Antiparkinsonian drug administration and plasma levels of penfluridol, a new long-acting neuroleptic.

1977 • 11 citations

Identification of a metabolite of thioridazine and mesoridazine from human plasma.

1975 • 11 citations

Binding of thioridazine and some of its metabolites to human serum protein and human albumin.

1975 • 10 citations

More Sensitive Gas-Chromatographic Measurement of Chlorpromazine in Plasma

1971 • 10 citations

Effects of conjugated estrogens on plasma butaperazine levels

1974 • 10 citations

Chlorpromazine Metabolism IV: Quaternization as a Key to Determination of Picomoles of Chlorpromazine and Other Tertiary Amine Drugs

1975 • 10 citations

ÉTUDE DE LA FLUORESCENCE DES DÉRIVÉS DE LA PHÉNOTHIAZINE

1966 • 10 citations

Determination of fluphenazine in plasma by ion-pair partition chromatography.

1976 • 9 citations

An attempt to establish quality control in determination of plasma chlorpromazine by a multilaboratory collaboration.

1975 • 9 citations

Gas-chromatographic separation of chlorpromazine, diazepam and N-desmethyldiazepam

1975 • 9 citations

A fluorometric method for the measurement of butaperazine in human plasma

1974 • 9 citations

Gas-Liquid Chromatographie Determination of Penfluridol in Plasma

1975 • 9 citations

Quantitation of chlorpromazine and its metabolites in human plasma and urine by direct spectrodensitometry of thin-layer chromatograms.

1974 • 8 citations

Chlorpromazine metabolism in humans. Part I

1973 • 8 citations

Chapter 5

1978 • 8 citations

Blood levels of thioridazine and some of its metabolites in psychiatric patients. A preliminary report.

1973 • 7 citations

Therapeutische Wirkung und Plasmaspiegel von Thioridazin (Melleril^®) bei schizophrenen Patienten

1975 • 7 citations

Butaperazine dimaleate metabolism

1974 • 6 citations

Gas-chromatographic methods for the study of chlorpromazine and some of its metabolities in human plasma.

1976 • 6 citations

Assay of 7-hydroxychlorpromazine, and failure to detect more than small quantities, in plasma of responding schizophrenics.

1975 • 5 citations

Plasma butaperazine levels in long-term chronic non-responding schizophrenics.

1977 • 5 citations

Isolation of a possible new metabolite of thioridazine and mesoridazine from human plasma.

1974 • 5 citations

Relationship of pharmacological models of bioavailability of chlorpromazine with drug and metabolite blood levels.

1976 • 4 citations

SERUM-THIORIDAZINE LEVELS AFTER DIFFERENT DOSAGE FORMS

1973 • 4 citations