Endosomal proteolysis of internalized proteins

The Biogenesis of Lysosomes

1989 • 1,583 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Macrophage endosomes contain proteases which degrade endocytosed protein ligands.

1985 • 223 citations

A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway

1995 • 219 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.

1993 • 206 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Uptake of Insulin and Other Ligands into Receptor-Rich Endocytic Components of Target Cells: The Endosomal Apparatus

1985 • 163 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Compartmentalized signal transduction by receptor tyrosine kinases

1995 • 144 citations

Cleavage of Parathyroid Hormone in Macrophage Endosomes Illustrates a Novel Pathway for Intracellular Processing of Proteins

1989 • 131 citations

Acidification and Ion Permeabilities of Highly Purified Rat Liver Endosomes

1989 • 123 citations

Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme.

1994 • 110 citations

Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.

1991 • 106 citations

Selective degradation of insulin within rat liver endosomes.

1990 • 106 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

Isolation of insulin degradation products from endosomes derived from intact rat liver.

1988 • 99 citations

Specific proteolysis regulates fusion between endocytic compartments in Xenopus oocytes

1987 • 87 citations

Proteolytic cleavage of ricin A chain in endosomal vesicles. Evidence for the action of endosomal proteases at both neutral and acidic pH.

1991 • 87 citations

Cellular proteolytic systems

1995 • 83 citations

Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells.

1995 • 83 citations

Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself

1993 • 77 citations

Characterization of endocytic compartments using the horseradish peroxidase-diaminobenzidine density shift technique.

1987 • 76 citations

Proteolysis of Glucagon within Hepatic Endosomes by Membrane-associated Cathepsins B and D

1995 • 71 citations

Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence.

1995 • 64 citations

The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.

1990 • 63 citations

Acid hydrolases in early and late endosome fractions from rat liver.

1991 • 58 citations

Activation of rat liver adenylate cyclase by cholera toxin requires toxin internalization and processing in endosomes

1991 • 57 citations

Cellular proteolytic systems

1994 • 54 citations

Degradation of endocytosed insulin in rat liver is mediated by low-density vesicles

1985 • 51 citations

Sequential processing of epidermal growth factor in early and late endosomes of rat liver

1991 • 51 citations

Diminished antigen processing by endosomal acidification mutant antigen-presenting cells.

1989 • 50 citations

Selective translocation of the A chain of diphtheria toxin across the membrane of purified endosomes.

1992 • 41 citations

Reconstitution of Endosomal Proteolysis in a Cell-free System

1989 • 38 citations

Hydrolases in intracellular compartments of rat liver cells

1991 • 34 citations

Kinetics of hydrolysis of endocytosed substrates by mammalian cultured cells: Early introduction of lysosomal enzymes into the endocytic pathway

1990 • 30 citations

Postendocytic maturation of acid hydrolases: evidence of prelysosomal processing.

1987 • 28 citations

Ligand-mediated internalization of glucagon receptors in intact rat liver.

1992 • 27 citations

Fate of injected glucagon taken up by rat liver in vivo. Degradation of internalized ligand in the endosomal compartment

1990 • 26 citations

Degradation of glucagon in isolated liver endosomes. ATP-dependence and partial characterization of degradation products

1991 • 24 citations

Endosomal Proteolysis Precedes Ricin A-Chain Toxicity in Macrophages

1993 • 22 citations

Immunolocalization of Endosomal Cathepsin D in Rabbit Alveolar Macrophages

1990 • 20 citations

Intracellular degradation of asialoglycoproteins in hepatocytes starts in a subgroup of lysosomes

1985 • 19 citations

Transient membrane association of the precursors of cathepsin C during their transfer into lysosomes

1991 • 15 citations

Antigen presentation by B lymphoma cells. Requirements for processing of exogenous antigen internalized through transferrin receptors.

1993 • 14 citations

Ligand-mediated internalization of glucagon receptors in intact rat liver

1992 • 13 citations