Prevention of Immune Reactions Triggered by First-Generation Adenoviral Vectors by Monoclonal Antibodies and CTLA4Ig

Dystrophin: The protein product of the duchenne muscular dystrophy locus

1987 • 4,477 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1995 • 1,048 citations

Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts

1989 • 856 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus

1991 • 647 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Myoblast Transfer in the Treatment of Duchenne's Muscular Dystrophy

1995 • 513 citations

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis

1994 • 460 citations

Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice

1993 • 455 citations

Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation

1992 • 429 citations

In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts.

1990 • 369 citations

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

1991 • 348 citations

Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice

1993 • 345 citations

Results of a Triple Blind Clinical Study of Myoblast Transplantations without Immunosuppressive Treatment in Young Boys with Duchenne Muscular Dystrophy

1993 • 335 citations

Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector

1990 • 325 citations

Plasmid DNA Is Superior to Viral Vectors for Direct Gene Transfer into Adult Mouse Skeletal Muscle

1993 • 314 citations

Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy

1993 • 310 citations

Myoblast transfer in duchenne muscular dystrophy

1993 • 304 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

Adenovirus as an expression vector in muscle cells in vivo.

1992 • 301 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

Long–term hepatic adenovirus–mediated gene expression in mice following CTLA4Ig administration

1995 • 281 citations

AN INCREASED INCIDENCE OF EPSTEIN-BARR VIRUS INFECTION AND LYMPHOPROLIFERATIVE DISORDER IN YOUNG CHILDREN ON FK506 AFTER LIVER TRANSPLANTATION1

1995 • 275 citations

Prolonged Transgene Expression in Cotton Rat Lung with Recombinant Adenoviruses Defective in E2a

1994 • 212 citations

A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity

1994 • 209 citations

Long–term correction of mouse dystrophic degeneration by adenovirus–mediated transfer of a minidystrophin gene

1993 • 201 citations

Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions

1991 • 201 citations

Very efficient myoblast allotransplantation in mice under FK506 immunosuppression

1994 • 198 citations

NEPHROTOXICITY FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION

1994 • 198 citations

NEPHROTOXICITY FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION

1994 • 194 citations

Gene Transfer into Skeletal Muscles by Isogenic Myoblasts

1994 • 191 citations

Islet Allograft Survival After a Single Course of Treatment of Recipient with Antibody to L3T4

1987 • 179 citations

MAJOR INFECTIOUS COMPLICATIONS AFTER ORTHOTOPIC LIVER TRANSPLANTATION AND COMPARISON OF OUTCOMES IN PATIENTS RECEIVING CYCLOSPORINE OR FK506 AS PRIMARY IMMUNOSUPPRESSION

1995 • 171 citations

INHIBITION OF TRANSPLANT REJECTION FOLLOWING TREATMENT WITH ANTI-B7-2 AND ANTI-B7-1 ANTIBODIES

1995 • 165 citations

FK506 Immunosuppression to Control the Immune Reactions Triggered by First-Generation Adenovirus-Mediated Gene Transfer

1995 • 160 citations

High efficiency of muscle regeneration after human myoblast clone transplantation in SCID mice.

1994 • 160 citations

NEUROTOXICITY AFTER ORTHOTOPIC LIVER TRANSPLANTATION

1994 • 154 citations

Neurotoxicity after orthotopic liver transplantation. A comparison between cyclosporine and FK506.

1994 • 153 citations

Adenoviral-mediated gene transfer to renal tubular cells in vivo

1994 • 134 citations

Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

1993 • 120 citations

Constitutive and cytokine-induced expression of human leukocyte antigens and cell adhesion molecules by human myotubes.

1993 • 110 citations

The Depletion of T Cell Subsets in Vitro and in Vivo

1986 • 105 citations

Intraperitoneal in vivo gene therapy to deliver alpha 1-antitrypsin to the systemic circulation.

1994 • 104 citations

NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A

1992 • 95 citations

The effect of anti-L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts.

1987 • 92 citations

Successful histocompatible myoblast transplantation in dystrophin-deficient mdx mouse despite the production of antibodies against dystrophin.

1995 • 88 citations

DONOR-RECIPIENT MICROCHIMERISM IS NOT REQUIRED FOR TOLERANCE INDUCTION FOLLOWING RECIPIENT PRETREATMENT WITH DONOR-SPECIFIC TRANSFUSION AND ANTI-CD4 ANTIBODY

1995 • 86 citations

The use of monoclonal antibodies to achieve immunological tolerance

1993 • 86 citations

Role of early genes in pathogenesis of adenovirus pneumonia.

1990 • 81 citations

Lymphocyte infiltration following allo‐and xenomyoblast transplantation in mdx mice

1995 • 80 citations

Transient immunosuppressive treatment leads to long-term retention of allogeneic myoblasts in hybrid myofibers.

1994 • 68 citations

Cell and Gene Therapy in Duchenne Muscular Dystrophy

1994 • 51 citations

Immunosuppression by FK506 Markedly Prolongs Expression of Adenovirus-Delivered Transgene in Skeletal Muscles of Adult Dystrophic [mdx] Mice

1995 • 43 citations

Expression of a recombinant dystrophin in mdx mice using adenovirus vector

1994 • 25 citations

Tolerance Induction in the Adult Using Monoclonal Antibodies to CD4, CD8, and CD11a (LFA-1)

1989 • 24 citations

INABILITY OF DENDRITIC CELLS TO PREVENT THE BLOOD TRANSFUSION EFFECT IN A MOUSE CARDIAC ALLOGRAFT MODEL

1987 • 18 citations

Cardiotoxicity of long-term intravenous administration of FK506 in rabbits: dose relationship and recovery after discontinuance.

1994 • 17 citations

Lymphocyte changes associated with prolongation of cardiac allograft survival in adult mice using anti-CD4 monoclonal antibody

1993 • 15 citations

The use of monoclonal antibodies to achieve immunological tolerance

1993 • 9 citations