Cancer gene therapy: developments to 2000

The Hallmarks of Cancer

2000 • 27,569 citations

Dendritic cells and the control of immunity

1998 • 14,345 citations

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Chemokines

2000 • 3,773 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

1998 • 1,666 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

2000 • 1,092 citations

Chemokines and Cell Migration in Secondary Lymphoid Organs

1999 • 1,046 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

2000 • 967 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

2000 • 868 citations

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

2000 • 788 citations

An innate sense of danger

1998 • 752 citations

Reovirus Therapy of Tumors with Activated Ras Pathway

1998 • 740 citations

Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

1996 • 708 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

Dendritic Cells in Cancer Immunotherapy

2000 • 698 citations

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

1997 • 694 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

1997 • 596 citations

Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells.

1997 • 589 citations

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

2000 • 586 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

A humanized system for pharmacologic control of gene expression

1996 • 533 citations

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1997 • 502 citations

Adenovirus-Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer

1999 • 492 citations

Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial

1999 • 486 citations

Cloning of human telomerase catalytic subunit(hTERT)gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

2002 • 475 citations

Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer.

1999 • 468 citations

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

1998 • 455 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

1999 • 392 citations

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

1998 • 376 citations

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

2000 • 355 citations

Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy in Patients with Localized Malignancy: Results of a Phase I Clinical Trial in Malignant Mesothelioma

1998 • 352 citations

Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake

1999 • 332 citations

Spatial and temporal control of gene therapy using ionizing radiation

1995 • 316 citations

Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer

1999 • 308 citations

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

1994 • 308 citations

A Novel Tumor-Specific Replication-Restricted Adenoviral Vector for Gene Therapy of Hepatocellular Carcinoma

1999 • 285 citations

Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

1994 • 277 citations

A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Recurrent Glioblastoma

1998 • 268 citations

A Phase 1-2 Clinical Trial of Gene Therapy for Recurrent Glioblastoma Multiforme by Tumor Transduction with the Herpes Simplex Thymidine Kinase Gene Followed by Ganciclovir

1999 • 252 citations

Eliciting T Cell Immunity Against Poorly Immunogenic Tumors by Immunization with Dendritic Cell-Tumor Fusion Vaccines

1998 • 236 citations

Targeting adenovirus

2000 • 233 citations

Cancer gene therapy: hard lessons and new courses

2000 • 230 citations

Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases

2000 • 226 citations

Prodrug-activating systems in suicide gene therapy

2000 • 224 citations

The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts.

1999 • 219 citations

TAP off - tumors on

1997 • 215 citations

Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer.

1999 • 211 citations

Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth

1997 • 204 citations

Double Suicide Gene Therapy Augments the Antitumor Activity of a Replication-Competent Lytic Adenovirus through Enhanced Cytotoxicity and Radiosensitization

2000 • 185 citations

Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection.

1998 • 179 citations

Macrophage inflammatory protein 3α transgene attracts dendritic cells to established murine tumors and suppresses tumor growth

2000 • 174 citations

Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines.

1999 • 173 citations

Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase.

1999 • 171 citations

A Phase I Study of Adenovirus-Mediated Wild-Type p53 Gene Transfer in Patients with Advanced Non-Small Cell Lung Cancer

1998 • 167 citations

Comparative Analysis of Genetically Modified Dendritic Cells and Tumor Cells as Therapeutic Cancer Vaccines

2000 • 158 citations

Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration

1998 • 154 citations

Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers.

1999 • 151 citations

Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth.

2000 • 148 citations

Synergistic Anticancer Effects of Ganciclovir/Thymidine Kinase and 5-Fluorocytosine/Cytosine Deaminase Gene Therapies

1998 • 147 citations

Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".

1996 • 146 citations

Genetic Targeting of Adenoviral Vectors

2000 • 143 citations

Gene delivery from replication-selective viruses: arming guided missiles in the war against cancer

2000 • 133 citations

A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer.

2000 • 128 citations

Conditionally replicating herpes vectors for cancer therapy

2000 • 126 citations

Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy.

1998 • 119 citations

Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model.

1997 • 117 citations

Apoptosis or necrosis for tumor immunotherapy: what's in a name?

1999 • 113 citations

Uses of granulocyte-macrophage colony-stimulating factor in vaccine development

2000 • 110 citations

Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts.

1997 • 94 citations

Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression

2000 • 92 citations

Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.

2000 • 90 citations

FLT3: Receptor and Ligand. Biology and Potential Clinical Application

1998 • 87 citations

Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo.

1997 • 86 citations

Telomeres, Telomerase, and Cancer

2000 • 78 citations

Regression of Hepatocellular Carcinoma in Vitro and in Vivo by Radiosensitizing Suicide Gene Therapy under the Inducible and Spatial Control of Radiation

1999 • 75 citations

Tumor necrosis factor-alpha-based gene therapy enhances radiation cytotoxicity in human prostate cancer.

1999 • 72 citations

Ovarian cancer BRCA1 gene therapy: Phase I and II trial differences in immune response and vector stability.

1999 • 72 citations

Tumor-Induced Immunosuppression: A Barrier to Immunotherapy of Large Tumors by Cytokine-Secreting Tumor Vaccine

2000 • 70 citations

Dendritic cells fused with mastocytoma cells elicit therapeutic antitumor immunity

1998 • 70 citations

An overview of cancer immunotherapy

2000 • 65 citations

Relative activity and specificity of promoters from prostate-expressed genes

1998 • 63 citations

Viral vector targeting

1999 • 62 citations

Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy.

1997 • 62 citations

Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model

2000 • 62 citations

Anti-tumour activity against B16-F10 melanoma with a GM-CSF secreting allogeneic tumour cell vaccine

1999 • 61 citations

Antisense therapy of hematologic malignancies.

1999 • 61 citations

Replicating vectors for gene therapy of cancer: risks, limitations and prospects

1994 • 56 citations

Telomerase in cancer: diagnostic, prognostic, and therapeutic implications.

1998 • 46 citations

Systemic Delivery of Antiangiogenic Adenovirus AdmATF Induces Liver Resistance to Metastasis and Prolongs Survival of Mice

1999 • 46 citations

Tumor Angiogenesis and Endothelial Cell Modulatory Factors

1999 • 42 citations

Suicide Gene Therapy

2002 • 37 citations

Tumor angiogenesis: biology and therapeutic prospects.

1999 • 34 citations

Comparison of combination therapy with paclitaxel and cisplatin versus cyclophosphamide and cisplatin in patients with suboptimal stage III and stage IV ovarian cancer: a Gynecologic Oncology Group study.

1997 • 33 citations

Preclinical and Clinical Pharmacology of Antisense Oligonucleotides

1999 • 32 citations

In vivo expression of prostate-specific adenoviral vectors in a canine model

1999 • 30 citations

In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy.

2000 • 20 citations

The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase

2000 • 18 citations

Ribozymes

2002 • 12 citations